HitPredict

Interactor 1: LMBL2 (P59178)
Lethal(3)malignant brain tumor-like protein 2 (L(3)mbt-like protein 2)
Gene: L3mbtl2

Interactor 2: CBX5 (Q61686)
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29795351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0035064 - methylated histone binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 703 Mm			1 191
+	Mm
		886512 LMBL2_MOUSE (1-703): 0: 1029: 100.00		Q9DCC5_MOUSE (1-181): 4.97e-62: 192: 60.22
+	Hs
		1027168 LMBL2_HUMAN (1-703): 0: 1015: 90.92		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Mm
		886478 LMBL2_MOUSE (1-703): 0: 1029: 100.00		CBX1_MOUSE (26-180): 3.2e-56: 177: 64.74
+	Hs
		949859 LMBL2_HUMAN (1-703): 0: 1015: 90.92		CBX1_HUMAN (26-180): 3.2e-56: 177: 64.74
+	Hs
		203755 LMBL2_HUMAN (1-703): 0: 1015: 90.92		SUV91_HUMAN (4-120): 2.31e-34: 127: 20.51
+	Hs
		1027335 SCML2_HUMAN (161-392): 4.29e-81: 273: 27.04		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		123346 SCML2_HUMAN (161-392): 4.29e-81: 273: 27.04		CBX4_HUMAN (11-125): 2.1e-27: 109: 25.22
+	Hs
		1059204 SCML2_HUMAN (161-392): 4.29e-81: 273: 27.04		CBX2_HUMAN (10-109): 8.73e-25: 102: 32.00
+	Hs
		316204 SCML2_HUMAN (161-392): 4.29e-81: 273: 27.04		CBX6_HUMAN (11-119): 5.27e-25: 101: 25.98
+	Hs
		1335794 SCML2_HUMAN (161-392): 4.29e-81: 273: 27.04		CBX8_HUMAN (11-88): 8.14e-25: 100: 34.62
+	Hs
		800560 LMBL1_HUMAN (140-323): 1.43e-24: 111: 21.20		CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91
+	Dm
		1369161 SMBT_DROME (138-401): 4.29e-35: 145: 21.53		Q9W396_DROME (19-175): 1.98e-53: 172: 50.32
+	Hs
		1027347 LMBL1_HUMAN (140-323): 1.43e-24: 111: 21.20		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		123303 SCMH1_HUMAN (502-613): 9.48e-27: 117: 36.84		CBX4_HUMAN (11-125): 2.1e-27: 109: 25.22
+	Hs
		1059182 SCMH1_HUMAN (502-613): 9.48e-27: 117: 36.84		CBX2_HUMAN (10-109): 8.73e-25: 102: 32.00
+	Hs
		316124 SCMH1_HUMAN (502-613): 9.48e-27: 117: 36.84		CBX6_HUMAN (11-119): 5.27e-25: 101: 25.98
+	Hs
		1292155 SCMH1_HUMAN (502-613): 9.48e-27: 117: 36.84		CBX8_HUMAN (11-88): 8.14e-25: 100: 34.62
+	Hs
		1059207 LMBL1_HUMAN (140-323): 1.43e-24: 111: 21.20		CBX2_HUMAN (10-109): 8.73e-25: 102: 32.00