Protein: DHCR7
7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Delta7-sterol reductase) (Sterol Delta(7)-reductase) (Sterol reductase SR-2)

Gene: DHCR7
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q9UBM7

Gene Ontology (top 5):
GO:0005640 - nuclear outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006695 - cholesterol biosynthetic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130271

PGRC1
Membrane-associated progesterone receptor component 1

2

2

High-throughput

0.611

High

564494

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

699219

CALX
Calnexin

1

2

High-throughput

0.536

High

1381361

NCLN
BOS complex subunit NCLN

1

1

High-throughput

0.536

High

1382233

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1434661

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

218906

TGON2
Trans-Golgi network integral membrane protein 2

2

2

High-throughput

0.533

High

401641

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

2

High-throughput

0.533

High

978375

RHOB
Rho-related GTP-binding protein RhoB

2

17

High-throughput

0.533

High

436750

KPCB
Protein kinase C beta type

2

2

High-throughput

0.521

High

835773

KPCI
Protein kinase C iota type

2

2

High-throughput

0.521

High

1253751

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

1316250

DOCK3
Dedicator of cytokinesis protein 3

2

2

High-throughput

0.521

High

160775

TOR1A
Torsin-1A

1

1

High-throughput

0.515

High

248636

FADS1
Acyl-CoA

1

1

High-throughput

0.515

High

1448845

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.515

High

1325940

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

243184

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

291578

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

374255

RASN
GTPase NRas

1

7

High-throughput

0.479

High

376052

RASK
GTPase KRas

1

7

High-throughput

0.479

High

404511

GCR
Glucocorticoid receptor

1

3

Small-scale

0.479

High

417824

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

418493

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

466509

RHOC
Rho-related GTP-binding protein RhoC

1

14

High-throughput

0.479

High

487846

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

562463

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

581353

RAC2
Ras-related C3 botulinum toxin substrate 2

1

14

High-throughput

0.479

High

611404

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

634680

LMNB1
Lamin-B1

1

5

High-throughput

0.479

High

643118

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

650466

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.479

High

715823

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

787093

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.479

High

820769

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.479

High

847735

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

880729

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

895131

EMD
Emerin

1

2

High-throughput

0.479

High

902125

RAB9A
Ras-related protein Rab-9A

1

5

High-throughput

0.479

High

904179

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.479

High

951493

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

953733

RAC3
Ras-related C3 botulinum toxin substrate 3

1

16

High-throughput

0.479

High

955714

CDC42
Cell division control protein 42 homolog

1

17

High-throughput

0.479

High

956525

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

962593

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

975291

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

988789

RAC1
Ras-related C3 botulinum toxin substrate 1

1

16

High-throughput

0.479

High

998903

H31
Histone H3.1

1

3

High-throughput

0.479

High

1015877

RHOG
Rho-related GTP-binding protein RhoG

1

14

High-throughput

0.479

High

1027229

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.479

High

1058707

CKAP4
Cytoskeleton-associated protein 4

1

4

High-throughput

0.479

High

1087329

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1203097

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

1247027

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1249291

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1287460

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

High-throughput

0.479

High

1294278

GOLI
E3 ubiquitin-protein ligase RNF130

1

5

High-throughput

0.479

High

1334050

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1334606

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

1335029

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1352003

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1352393

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1383137

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1393789

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1401252

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1404259

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1421174

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1431279

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.479

High

1431780

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

1436350

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1447905

SAR1A
Small COPII coat GTPase SAR1A

1

7

High-throughput

0.479

High

1448036

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

1452719

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

1454853

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

1458500

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

1405697

NECD
Necdin

1

1

High-throughput

0.470

High

180092

BET1
BET1 homolog

1

0

High-throughput

0.458

High

346442

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

353605

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

508763

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

548382

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

787263

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

800144

COIL
Coilin

1

0

High-throughput

0.458

High

932607

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.458

High

941984

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1104521

ILK
Scaffold protein ILK

1

0

High-throughput

0.458

High

1114537

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1147872

DHC24
Delta(24)-sterol reductase

1

0

Small-scale

0.458

High

1252274

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1253004

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1381545

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1403602

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1449580

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.458

High

923446

SC5A3
Sodium/myo-inositol cotransporter

1

2

High-throughput

0.445

High

1335760

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

125648

LEG9
Galectin-9

1

1

High-throughput

0.437

High

126854

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.437

High

189022

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

189902

STX7
Syntaxin-7

1

3

High-throughput

0.437

High

191142

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.437

High

318898

RHBT1
Rho-related BTB domain-containing protein 1

1

15

High-throughput

0.437

High

343286

ERR2
Steroid hormone receptor ERR2

1

3

High-throughput

0.437

High

350165

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.437

High

589933

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

601479

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.437

High

610060

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.437

High

630074

BTF3
Transcription factor BTF3

1

2

High-throughput

0.437

High

630657

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.437

High

631006

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.437

High

696754

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720350

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.437

High

769409

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

879572

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

883351

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.437

High

886334

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.437

High

886601

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.437

High

901083

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

905236

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

910240

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.437

High

958531

ACTZ
Alpha-centractin

1

1

High-throughput

0.437

High

962849

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.437

High

965303

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

971229

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1005205

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1017267

H33
Histone H3.3

1

3

High-throughput

0.437

High

1067791

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

1107299

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.437

High

1135148

CUL7
Cullin-7

1

1

High-throughput

0.437

High

1145150

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.437

High

1151915

RHOH
Rho-related GTP-binding protein RhoH

1

16

High-throughput

0.437

High

1186394

PKHG6
Pleckstrin homology domain-containing family G member 6

1

2

High-throughput

0.437

High

1238845

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1255928

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1271031

RHOU
Rho-related GTP-binding protein RhoU

1

19

High-throughput

0.437

High

1276907

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1286946

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1312621

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.437

High

1323030

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1331270

ARL10
ADP-ribosylation factor-like protein 10

1

6

High-throughput

0.437

High

1360956

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1366901

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.437

High

1367489

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1392492

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1396651

RHOV
Rho-related GTP-binding protein RhoV

1

16

High-throughput

0.437

High

1397520

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1419427

RHBT2
Rho-related BTB domain-containing protein 2

1

15

High-throughput

0.437

High

1433559

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.437

High

1434129

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1438219

RHOF
Rho-related GTP-binding protein RhoF

1

19

High-throughput

0.437

High

1450124

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1453541

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.437

High

1458497

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1458498

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.437

High

1458501

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.437

High

411099

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.426

High

870333

S6A12
Sodium- and chloride-dependent betaine transporter

1

0

High-throughput

0.426

High

1458499

AGO2
Protein argonaute-2

1

0

High-throughput

0.426

High

1458502

S27A5
Long-chain fatty acid transport protein 5

1

0

High-throughput

0.426

High

1150

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

143482

E2F3
Transcription factor E2F3

1

1

Small-scale

0.407

High

425663

ISG15
Ubiquitin-like protein ISG15

1

1

Small-scale

0.407

High

530503

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.407

High

1130500

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.407

High

1157206

S15A2
Solute carrier family 15 member 2

1

2

High-throughput

0.407

High

1168620

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

2

High-throughput

0.407

High

1227625

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1234999

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.407

High

1452353

SC5A4
Probable glucose sensor protein SLC5A4

1

2

High-throughput

0.407

High

154899

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.279

Low

317940

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

1052383

RN5A
2-5A-dependent ribonuclease

1

0

High-throughput

0.279

Low

459343

CATL1
Procathepsin L

1

0

High-throughput

0.249

Low

664823

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.249

Low

893647

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

976633

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1004227

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.249

Low

1026575

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

1121357

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

1155861

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1229736

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1233546

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1250209

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1333357

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1357591

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

1399011

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1431222

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.249

Low

1446370

PPA6
Lysophosphatidic acid phosphatase type 6

1

0

High-throughput

0.249

Low

1446988

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1450459

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.249

Low

1458503

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

653635

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1158852

VACHT
Vesicular acetylcholine transporter

1

0

High-throughput

0.232

Low

1446080

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025