HitPredict

Interactor 1: D3ZUY8 (D3ZUY8)
AP-2 complex subunit alpha
Gene: Ap2a1

Interactor 2: Q5JC29 (Q5JC29)
Epidermal growth factor receptor pathway substrate 15 isoform B
Gene: Eps15

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16903783
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016324 - apical plasma membrane GO:0030122 - AP-2 adaptor complex GO:0030136 - clathrin-coated vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 956 Rn			1 792
+	Hs
		321504 AP2A1_HUMAN (1-956): 0: 858: 95.09		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Rn
		1126749 Q66HM2_RAT (1-956): 0: 836: 80.19		Q5JC29_RAT (1-792): 1.51e-137: 427: 100.00
+	Hs
		302112 AP2A2_HUMAN (1-956): 0: 822: 79.08		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Mm
		567515 AP2A2_MOUSE (1-956): 0: 832: 80.94		EPS15_MOUSE (1-777): 4.77e-126: 400: 94.34
+	Hs
		321661 AP2A1_HUMAN (1-956): 0: 858: 95.09		EP15R_HUMAN (1-790): 2.69e-95: 318: 41.01
+	Rn
		88768 D3ZUY8_RAT (1-956): 0: 885: 100.00		ITSN1_RAT (9-776): 1.45e-80: 285: 16.87
+	Hs
		302221 AP2A2_HUMAN (1-956): 0: 822: 79.08		EP15R_HUMAN (1-790): 2.69e-95: 318: 41.01
+	Hs
		787890 AP2B1_HUMAN (36-951): 0: 654: 17.03		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Rn
		923853 AP2B1_RAT (36-951): 0: 654: 17.03		Q5JC29_RAT (1-792): 1.51e-137: 427: 100.00
+	Hs
		321552 AP2A1_HUMAN (1-956): 0: 858: 95.09		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Hs
		321615 AP2A1_HUMAN (1-956): 0: 858: 95.09		REPS1_HUMAN (2-493): 7.62e-28: 122: 12.28
+	Hs
		302157 AP2A2_HUMAN (1-956): 0: 822: 79.08		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Hs
		321600 AP2A1_HUMAN (1-956): 0: 858: 95.09		REPS2_HUMAN (39-606): 2.04e-20: 98.2: 14.33
+	Hs
		302193 AP2A2_HUMAN (1-956): 0: 822: 79.08		REPS1_HUMAN (2-493): 7.62e-28: 122: 12.28
+	Hs
		321640 AP2A1_HUMAN (1-956): 0: 858: 95.09		EHD1_HUMAN (17-102): 1.92e-16: 85.4: 33.72
+	Rn
		923861 AP2B1_RAT (36-951): 0: 654: 17.03		ITSN1_RAT (9-776): 1.45e-80: 285: 16.87
+	Ce
		1094946 Q22601_CAEEL (1-956): 0: 765: 61.29		Q9U2T9_CAEEL (6-767): 5.71e-42: 167: 14.23
+	Dm
		91156 AP2A_DROME (3-956): 0: 777: 67.26		E3CTP7_DROME (425-783): 3.61e-11: 68.9: 13.65
+	Hs
		925876 AP2B1_HUMAN (36-951): 0: 654: 17.03		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Sc
		710371 AP2A_YEAST (10-954): 0: 673: 25.94		EDE1_YEAST (3-329): 6.23e-18: 91.3: 23.62