HitPredict

Interactor 1: D3ZUY8 (D3ZUY8)
AP-2 complex subunit alpha
Gene: Ap2a1

Interactor 2: ITSN1 (Q9WVE9)
Intersectin-1 (EH domain and SH3 domain regulator of endocytosis 1)
Gene: ITSN1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	16903783
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 956 Rn			1 1713
+	Hs
		321552 AP2A1_HUMAN (1-956): 0: 858: 95.09		ITSN1_HUMAN (1-1713): 0: 883: 93.32
+	Hs
		302157 AP2A2_HUMAN (1-956): 0: 822: 79.08		ITSN1_HUMAN (1-1713): 0: 883: 93.32
+	Rn
		923861 AP2B1_RAT (36-951): 0: 654: 17.03		ITSN1_RAT (1-1713): 0: 897: 100.00
+	Hs
		925876 AP2B1_HUMAN (36-951): 0: 654: 17.03		ITSN1_HUMAN (1-1713): 0: 883: 93.32
+	Hs
		926031 AP2B1_HUMAN (36-951): 0: 654: 17.03		ITSN2_HUMAN (1-1712): 0: 738: 55.31
+	Hs
		321504 AP2A1_HUMAN (1-956): 0: 858: 95.09		EPS15_HUMAN (176-898): 2.17e-34: 145: 15.85
+	Hs
		302112 AP2A2_HUMAN (1-956): 0: 822: 79.08		EPS15_HUMAN (176-898): 2.17e-34: 145: 15.85
+	Rn
		88764 D3ZUY8_RAT (1-956): 0: 885: 100.00		Q5JC29_RAT (448-619): 7.54e-14: 78.9: 10.98
+	Hs
		321661 AP2A1_HUMAN (1-956): 0: 858: 95.09		EP15R_HUMAN (472-920): 1.42e-18: 94.7: 12.42
+	Hs
		302221 AP2A2_HUMAN (1-956): 0: 822: 79.08		EP15R_HUMAN (472-920): 1.42e-18: 94.7: 12.42
+	Rn
		1126749 Q66HM2_RAT (1-956): 0: 836: 80.19		Q5JC29_RAT (448-619): 7.54e-14: 78.9: 10.98
+	Mm
		567515 AP2A2_MOUSE (1-956): 0: 832: 80.94		EPS15_MOUSE (472-640): 6.85e-14: 79.3: 22.35
+	Ce
		1094946 Q22601_CAEEL (1-956): 0: 765: 61.29		Q9U2T9_CAEEL (674-1210): 2.06e-21: 104: 14.17
+	Dm
		91156 AP2A_DROME (3-956): 0: 777: 67.26		E3CTP7_DROME (501-700): 6.1e-11: 69.7: 13.50
+	Hs
		787890 AP2B1_HUMAN (36-951): 0: 654: 17.03		EPS15_HUMAN (176-898): 2.17e-34: 145: 15.85
+	Hs
		787903 AP1B1_HUMAN (36-951): 0: 647: 17.33		EPS15_HUMAN (176-898): 2.17e-34: 145: 15.85
+	Hs
		926038 AP2B1_HUMAN (36-951): 0: 654: 17.03		EP15R_HUMAN (472-920): 1.42e-18: 94.7: 12.42
+	Rn
		923853 AP2B1_RAT (36-951): 0: 654: 17.03		Q5JC29_RAT (448-619): 7.54e-14: 78.9: 10.98
+	Mm
		788007 AP2B1_MOUSE (36-951): 0: 653: 17.03		EPS15_MOUSE (472-640): 6.85e-14: 79.3: 22.35
+	Hs
		925892 AP2B1_HUMAN (36-951): 0: 654: 17.03		SH319_HUMAN (966-1210): 2.1e-10: 67.8: 25.47