HitPredict

Interactor 1: ACT (P60010)
Actin (EC 3.6.4.-)
Gene: ACT1

Interactor 2: BRE1 (Q07457)
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)
Gene: BRE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21179020
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Sc			1 700
+	Hs
		724859 ACTBL_HUMAN (2-375): 0: 687: 83.42		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		932202 ACTC_HUMAN (2-375): 0: 591: 87.17		BRE1A_HUMAN (60-700): 2.47e-34: 142: 15.11
+	Hs
		891686 ACTB_HUMAN (1-375): 0: 601: 88.80		MAP1A_HUMAN (197-650): 1.05e-25: 115: 13.32
+	Rn
		892228 ACTB_RAT (1-375): 0: 601: 88.80		MYH9_RAT (255-666): 4.36e-18: 91.3: 12.47
+	Hs
		724738 ACTB_HUMAN (1-375): 0: 601: 88.80		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Rn
		892236 ACTB_RAT (1-375): 0: 601: 88.80		MYH10_RAT (245-667): 1.83e-16: 86.3: 10.64
+	Hs
		724762 ACTG_HUMAN (1-375): 0: 600: 89.07		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Rn
		92841 ACTB_RAT (1-375): 0: 601: 88.80		CTRO_RAT (100-632): 5.72e-16: 84.7: 11.34
+	Hs
		891935 ACTB_HUMAN (1-375): 0: 601: 88.80		MY18A_HUMAN (76-573): 1.31e-13: 77: 10.67
+	Hs
		148662 ACTC_HUMAN (2-375): 0: 591: 87.17		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		724766 ACTC_HUMAN (2-375): 0: 591: 87.17		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		929952 ACTG_HUMAN (1-375): 0: 600: 89.07		MY18A_HUMAN (76-573): 1.31e-13: 77: 10.67
+	Hs
		725136 ACTC_HUMAN (2-375): 0: 591: 87.17		MYH10_HUMAN (245-667): 3.3e-16: 85.5: 10.88
+	Hs
		930015 ACTG_HUMAN (1-375): 0: 600: 89.07		MYO5C_HUMAN (86-475): 3.22e-12: 72.3: 12.75
+	Dm
		116373 ACT1_DROME (2-375): 0: 596: 89.31		M9PI41_DROME (161-604): 4.62e-13: 75: 11.73
+	Dm
		116372 ACT2_DROME (2-375): 0: 594: 88.77		M9PI41_DROME (161-604): 4.62e-13: 75: 11.73
+	Hs
		932297 ACTC_HUMAN (2-375): 0: 591: 87.17		MY18A_HUMAN (76-573): 1.31e-13: 77: 10.67
+	Mm
		892205 ACTB_MOUSE (1-375): 0: 601: 88.80		MYH9_MOUSE (4-290): 1.61e-09: 63.5: 10.35
+	Hs
		932396 ACTC_HUMAN (2-375): 0: 591: 87.17		MYO5C_HUMAN (86-475): 3.22e-12: 72.3: 12.75
+	Dm
		404232 ACT6_DROME (2-375): 0: 593: 87.97		MYSA_DROME (136-643): 7.17e-10: 64.6: 14.80