Protein: PSB7
Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) (Proteasome subunit beta-2) (beta-2)

Gene: PSB7, PSMB7
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q99436

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004175 - endopeptidase activity
GO:0004298 - threonine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633775

PSB1
Proteasome subunit beta type-1

17

20

Small-scale

0.986

High

700947

PSB4
Proteasome subunit beta type-4

12

19

Small-scale

0.977

High

681217

PSA2
Proteasome subunit alpha type-2

9

20

Small-scale

0.974

High

887581

PSB3
Proteasome subunit beta type-3

9

20

Small-scale

0.972

High

700538

PSB9
Proteasome subunit beta type-9

9

20

Small-scale

0.968

High

1404132

POMP
Proteasome maturation protein

7

14

Small-scale

0.967

High

681703

PSA4
Proteasome subunit alpha type-4

8

20

Small-scale

0.966

High

701209

PSB5
Proteasome subunit beta type-5

7

18

Small-scale

0.963

High

887713

PSB2
Proteasome subunit beta type-2

7

20

Small-scale

0.954

High

701070

PSB6
Proteasome subunit beta type-6

6

18

Small-scale

0.949

High

165398

PSA7
Proteasome subunit alpha type-7

6

20

Small-scale

0.945

High

1054636

PSME1
Proteasome activator complex subunit 1

6

20

Small-scale

0.945

High

680997

PSA1
Proteasome subunit alpha type-1

6

20

High-throughput

0.941

High

954887

PSA6
Proteasome subunit alpha type-6

6

20

Small-scale

0.938

High

337490

PSMG1
Proteasome assembly chaperone 1

5

4

High-throughput

0.925

High

700714

PSA5
Proteasome subunit alpha type-5

5

20

High-throughput

0.925

High

1134875

PSME4
Proteasome activator complex subunit 4

5

11

High-throughput

0.925

High

1346585

PSMA8
Proteasome subunit alpha-type 8

5

20

Small-scale

0.921

High

1404128

PSME2
Proteasome activator complex subunit 2

5

20

Small-scale

0.919

High

700477

PSB8
Proteasome subunit beta type-8

5

19

Small-scale

0.910

High

128046

PSD11
26S proteasome non-ATPase regulatory subunit 11

4

20

High-throughput

0.903

High

681492

PSA3
Proteasome subunit alpha type-3

4

20

High-throughput

0.892

High

1363752

PSMF1
Proteasome inhibitor PI31 subunit

4

3

High-throughput

0.892

High

1404113

PSMG3
Proteasome assembly chaperone 3

4

4

High-throughput

0.892

High

960532

PSME3
Proteasome activator complex subunit 3

3

20

High-throughput

0.855

High

128301

PSD12
26S proteasome non-ATPase regulatory subunit 12

3

20

High-throughput

0.839

High

851398

PRS6B
26S proteasome regulatory subunit 6B

2

20

High-throughput

0.811

High

610445

PRS6A
26S proteasome regulatory subunit 6A

2

20

High-throughput

0.789

High

975488

PRS10
26S proteasome regulatory subunit 10B

2

20

High-throughput

0.789

High

1404111

PSB7
Proteasome subunit beta type-7

2

19

Small-scale

0.762

High

1404134

FBX7
F-box only protein 7

5

6

Small-scale

0.712

High

1404137

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

5

17

Small-scale

0.709

High

778760

PRS7
26S proteasome regulatory subunit 7

1

20

High-throughput

0.691

High

968790

PRS4
26S proteasome regulatory subunit 4

1

20

High-throughput

0.691

High

969028

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.691

High

1206302

PSMG4
Proteasome assembly chaperone 4

1

3

High-throughput

0.691

High

1136576

PSMD6
26S proteasome non-ATPase regulatory subunit 6

4

20

High-throughput

0.691

High

1381306

PSMG2
Proteasome assembly chaperone 2

4

11

High-throughput

0.691

High

138282

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

20

Small-scale

0.676

High

1135669

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

3

1

High-throughput

0.667

High

1404116

PIP30
PSME3-interacting protein

3

3

High-throughput

0.662

High

933713

PSMD4
26S proteasome non-ATPase regulatory subunit 4

3

11

Small-scale

0.656

High

1050517

UBE3A
Ubiquitin-protein ligase E3A

3

15

Small-scale

0.640

High

211022

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

9

High-throughput

0.628

High

1219328

ECM29
Proteasome adapter and scaffold protein ECM29

2

13

High-throughput

0.628

High

530258

TAU
Microtubule-associated protein tau

3

4

High-throughput

0.624

High

1404112

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

20

Small-scale

0.611

High

1098105

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

20

High-throughput

0.601

High

1404131

PSD13
26S proteasome non-ATPase regulatory subunit 13

2

13

High-throughput

0.601

High

1205672

Q5JNW7
Proteasome 20S subunit beta 8

1

20

Small-scale

0.590

High

930026

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

9

Small-scale

0.584

High

114608

H0YKT8
Proteasome subunit beta

1

20

High-throughput

0.575

High

822163

PSB10
Proteasome subunit beta type-10

1

20

Small-scale

0.575

High

358784

LDHA
L-lactate dehydrogenase A chain

1

5

High-throughput

0.536

High

451055

LDHB
L-lactate dehydrogenase B chain

1

5

High-throughput

0.536

High

539679

MBL2
Mannose-binding protein C

1

1

High-throughput

0.536

High

987168

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

15

High-throughput

0.536

High

992312

SKP1
S-phase kinase-associated protein 1

1

6

High-throughput

0.536

High

1140135

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

10

High-throughput

0.536

High

1147556

UBE3C
Ubiquitin-protein ligase E3C

1

18

High-throughput

0.536

High

1287418

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

18

High-throughput

0.536

High

1404118

ANKZ1
tRNA endonuclease ANKZF1

1

1

High-throughput

0.536

High

1404119

AKIR1
Akirin-1

1

8

High-throughput

0.536

High

1404120

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.536

High

1404127

AMFR
E3 ubiquitin-protein ligase AMFR

1

11

High-throughput

0.536

High

1404135

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

7

High-throughput

0.536

High

390258

FETA
Alpha-fetoprotein

1

0

High-throughput

0.518

High

843898

HD
Huntingtin

1

4

High-throughput

0.515

High

97083

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

181998

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

339834

KLF8
Krueppel-like factor 8

1

13

High-throughput

0.500

High

1038469

TIE2
Angiopoietin-1 receptor

1

2

High-throughput

0.500

High

1110881

IRF5
Interferon regulatory factor 5

1

9

High-throughput

0.500

High

1129180

IRF3
Interferon regulatory factor 3

1

9

High-throughput

0.500

High

1404115

KLF16
Krueppel-like factor 16

1

13

High-throughput

0.500

High

1404125

KLF15
Krueppel-like factor 15

1

13

High-throughput

0.500

High

170305

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

242681

PRKN
E3 ubiquitin-protein ligase parkin

1

16

Small-scale

0.479

High

260348

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

272406

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

282194

MAF
Transcription factor Maf

1

3

Small-scale

0.479

High

294217

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

315917

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

326605

MFN2
Mitofusin-2

1

4

High-throughput

0.479

High

425607

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

508489

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.479

High

539001

EPB41
Protein 4.1

1

2

High-throughput

0.479

High

604722

UBF1
Nucleolar transcription factor 1

1

2

High-throughput

0.479

High

607028

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

607636

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

3

High-throughput

0.479

High

766219

NOS2
Nitric oxide synthase, inducible

1

3

High-throughput

0.479

High

772411

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

861257

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.479

High

920220

PLK1
Serine/threonine-protein kinase PLK1

1

13

Small-scale

0.479

High

931702

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

957482

UBC12
NEDD8-conjugating enzyme Ubc12

1

9

High-throughput

0.479

High

970952

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

998719

H31
Histone H3.1

1

3

High-throughput

0.479

High

1097227

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.479

High

1121312

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.479

High

1125619

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

Small-scale

0.479

High

1156478

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

8

High-throughput

0.479

High

1197680

MIDN
Midnolin

1

4

High-throughput

0.479

High

1199887

AKIR2
Akirin-2

1

8

Small-scale

0.479

High

1216195

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

1229641

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1233865

DESI1
Desumoylating isopeptidase 1

1

3

Small-scale

0.479

High

1255192

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1280424

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

1288565

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

1291149

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

Small-scale

0.479

High

1338918

NUP43
Nucleoporin Nup43

1

6

High-throughput

0.479

High

1364535

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

17

High-throughput

0.479

High

1395641

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

5

Small-scale

0.479

High

1397335

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1404114

DERL1
Derlin-1

1

2

Small-scale

0.479

High

1404122

HECW2
E3 ubiquitin-protein ligase HECW2

1

8

High-throughput

0.479

High

1404123

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1404124

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

1404129

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

1404130

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

1404133

NINL
Ninein-like protein

1

5

High-throughput

0.479

High

1404136

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

Small-scale

0.479

High

775275

FUS
RNA-binding protein FUS

1

0

High-throughput

0.460

High

1026191

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

1158491

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

1235503

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1404117

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

412487

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.457

High

1147413

EPHA7
Ephrin type-A receptor 7

1

1

High-throughput

0.457

High

1404121

KLH11
Kelch-like protein 11

1

1

High-throughput

0.445

High

1404139

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

3

High-throughput

0.445

High

1371104

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.438

High

1249144

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1327146

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1356067

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

887155

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

709

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

1207756

TMM31
Transmembrane protein 31

1

6

High-throughput

0.407

High

1273791

NIPA1
Magnesium transporter NIPA1

1

3

High-throughput

0.407

High

1325644

SVOPL
Putative transporter SVOPL

1

3

High-throughput

0.407

High

1401537

S26A8
Testis anion transporter 1

1

2

High-throughput

0.407

High

1404126

ZPI
Protein Z-dependent protease inhibitor

2

0

Small-scale

0.310

High

254640

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

1289831

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1404138

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low

1384216

LDAF1
Lipid droplet assembly factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025