HitPredict

Interactor 1: D3ZV15 (D3ZV15)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cbl

Interactor 2: RET (G3V9H8)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16525057
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0030424 - axon GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Rn			1 1115
+	Hs
		434137 CBL_HUMAN (1-851): 0: 844: 91.56		RET_HUMAN (1-1115): 0: 1244: 85.29
+	Hs
		601457 CBL_HUMAN (1-851): 0: 844: 91.56		FGFR2_HUMAN (296-1066): 2.25e-173: 532: 26.52
+	Mm
		610584 CBL_MOUSE (1-871): 0: 863: 97.47		EGFR_MOUSE (428-1114): 1.28e-146: 472: 22.75
+	Mm
		610553 CBL_MOUSE (1-871): 0: 863: 97.47		VGFR1_MOUSE (292-1083): 8.32e-145: 470: 22.81
+	Rn
		88773 D3ZV15_RAT (1-894): 0: 865: 100.00		VGFR1_RAT (292-1083): 1.13e-142: 465: 22.09
+	Rn
		88782 D3ZV15_RAT (1-894): 0: 865: 100.00		Q9QX70_RAT (428-1114): 7.88e-143: 462: 22.21
+	Hs
		607879 CBL_HUMAN (1-851): 0: 844: 91.56		FGFR4_HUMAN (334-1055): 6.46e-154: 480: 28.44
+	Hs
		610266 CBL_HUMAN (1-851): 0: 844: 91.56		VGFR2_HUMAN (343-1082): 1.77e-143: 467: 24.51
+	Hs
		572586 CBL_HUMAN (1-851): 0: 844: 91.56		VGFR1_HUMAN (292-1111): 7.7e-142: 463: 21.37
+	Hs
		384266 CBL_HUMAN (1-851): 0: 844: 91.56		NTRK1_HUMAN (377-1019): 5.9e-142: 448: 24.13
+	Mm
		403532 CBL_MOUSE (1-871): 0: 863: 97.47		KIT_MOUSE (459-1049): 1.07e-132: 429: 26.81
+	Hs
		337933 CBL_HUMAN (1-851): 0: 844: 91.56		EGFR_HUMAN (428-1114): 1.36e-135: 443: 23.35
+	Hs
		610410 CBL_HUMAN (1-851): 0: 844: 91.56		ERBB4_HUMAN (434-1090): 1.12e-132: 437: 21.38
+	Hs
		610314 CBL_HUMAN (1-851): 0: 844: 91.56		EPHB1_HUMAN (595-1032): 4.76e-118: 390: 28.95
+	Hs
		384765 CBLB_HUMAN (23-727): 0: 726: 56.50		NTRK1_HUMAN (377-1019): 5.9e-142: 448: 24.13
+	Hs
		338362 CBLB_HUMAN (23-727): 0: 726: 56.50		EGFR_HUMAN (428-1114): 1.36e-135: 443: 23.35
+	Mm
		452178 CBL_MOUSE (1-871): 0: 863: 97.47		CSF1R_MOUSE (707-1019): 6.01e-74: 267: 39.67
+	Hs
		499234 CBL_HUMAN (1-851): 0: 844: 91.56		KIT_HUMAN (703-1025): 1.4e-75: 271: 39.84
+	Hs
		426985 CBL_HUMAN (1-851): 0: 844: 91.56		CSF1R_HUMAN (707-1019): 3.9e-75: 270: 40.22
+	Hs
		610268 CBL_HUMAN (1-851): 0: 844: 91.56		FLT3_HUMAN (707-1015): 7.4e-74: 267: 39.95