Interactor 1: D3ZVH5 (D3ZVH5)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27)
Gene: Mdm2

Interactor 2: P53 (P10361)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.749

The method score is based on:

Property Details
Experiments 23174211, 17060322, 22405968, 11983168, 8058315, 25912675, 28798142, 22046440, 16330492
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
and 23 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 458
Rn

1 391
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024