HitPredict

Interactor 1: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Interactor 2: IGSF8 (Q969P0)
Immunoglobulin superfamily member 8 (IgSF8) (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes-associated transmembrane protein 4) (KCT-4) (LIR-D1) (Prostaglandin regulatory-like protein) (PGRL) (CD antigen CD316)
Gene: IGSF8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	11673522, 33961781, 32900848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 236 Hs			1 613
+	Mm
		728559 CD81_MOUSE (1-236): 1.12e-60: 192: 91.95		IGSF8_MOUSE (22-613): 1.44e-171: 503: 90.20
+	Hs
		905541 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		602274 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		653096 CD82_HUMAN (4-234): 1.57e-49: 164: 23.11		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		326168 TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48		IGSF8_HUMAN (1-613): 5.61e-173: 507: 100.00
+	Hs
		887973 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		905572 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		819474 CD151_HUMAN (3-231): 1.89e-54: 176: 25.40		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		602290 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		1245273 TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		446077 CD63_HUMAN (1-232): 2.98e-52: 170: 22.95		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		653105 CD82_HUMAN (4-234): 1.57e-49: 164: 23.11		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		237768 TSN2_HUMAN (3-234): 1.88e-44: 150: 39.22		FPRP_HUMAN (37-604): 5.69e-51: 191: 19.72
+	Hs
		888000 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		ROBO1_HUMAN (25-507): 1.65e-32: 136: 12.83
+	Hs
		602297 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		ROBO1_HUMAN (25-507): 1.65e-32: 136: 12.83
+	Hs
		253639 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		IGSF3_HUMAN (19-305): 3.84e-20: 97.2: 17.89
+	Hs
		253625 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		IGSF3_HUMAN (19-305): 3.84e-20: 97.2: 17.89
+	Hs
		253665 TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65		IGSF3_HUMAN (19-305): 3.84e-20: 97.2: 17.89
+	Hs
		253614 TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48		IGSF3_HUMAN (19-305): 3.84e-20: 97.2: 17.89
+	Hs
		1199563 TSN33_HUMAN (9-233): 7.63e-51: 168: 22.78		TITIN_HUMAN (169-612): 1.96e-12: 72.9: 9.60