Protein: MCM5
Minichromosome maintenance protein 5 (EC 3.6.4.12) (Cell division control protein 46)

Gene: MCM5
Organism: Saccharomyces cerevisiae S288C
Interactions: 137
UniProt ID: P29496

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664417

MCM3
DNA replication licensing factor MCM3

24

20

Small-scale

0.990

High

713296

SLD5
DNA replication complex GINS protein SLD5

17

15

Small-scale

0.984

High

713311

CDC45
Cell division control protein 45

17

17

Small-scale

0.983

High

713243

MCM4
DNA replication licensing factor MCM4

18

19

Small-scale

0.983

High

712948

MCM2
DNA replication licensing factor MCM2

14

20

Small-scale

0.979

High

713262

MCM7
DNA replication licensing factor MCM7

10

19

Small-scale

0.971

High

713284

MCM6
DNA replication licensing factor MCM6

8

19

Small-scale

0.956

High

713280

CDT1
Cell division cycle protein CDT1

5

3

Small-scale

0.922

High

713270

PSF2
DNA replication complex GINS protein PSF2

4

12

Small-scale

0.878

High

713313

PSF3
DNA replication complex GINS protein PSF3

4

10

Small-scale

0.878

High

713318

PSF1
DNA replication complex GINS protein PSF1

4

12

Small-scale

0.878

High

642019

DPOE
DNA polymerase epsilon catalytic subunit A

2

11

Small-scale

0.755

High

713242

MCM5
Minichromosome maintenance protein 5

2

19

High-throughput

0.737

High

713294

CTF4
DNA polymerase alpha-binding protein

7

10

Small-scale

0.736

High

713246

MCM10
Minichromosome maintenance protein 10

6

13

Small-scale

0.734

High

713288

TOF1
Topoisomerase 1-associated factor 1

5

8

Small-scale

0.709

High

713285

SLD3
DNA replication regulator SLD3

3

3

Small-scale

0.655

High

713289

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.647

High

713249

SPT16
FACT complex subunit SPT16

3

5

Small-scale

0.633

High

440910

CDC7
Cell division control protein 7

2

20

Small-scale

0.625

High

381927

H4
Histone H4

3

8

High-throughput

0.624

High

526113

HSP72
Heat shock protein SSA2

3

16

High-throughput

0.624

High

713282

ORC5
Origin recognition complex subunit 5

1

7

Small-scale

0.618

High

561295

DPOLA
DNA polymerase alpha catalytic subunit A

2

11

Small-scale

0.611

High

713312

DIA2
Protein DIA2

2

3

Small-scale

0.611

High

713252

ORC2
Origin recognition complex subunit 2

2

8

Small-scale

0.602

High

544077

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.601

High

419638

H2A2
Histone H2A.2

2

20

High-throughput

0.571

High

665171

DPB2
DNA polymerase epsilon subunit B

2

4

Small-scale

0.571

High

677663

MRC1
Mediator of replication checkpoint protein 1

2

3

Small-scale

0.571

High

713269

ATAD2
ATPase histone chaperone YTA7

2

4

High-throughput

0.571

High

713263

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

2

5

High-throughput

0.552

High

713272

SA185
SIT4-associating protein SAP185

2

0

High-throughput

0.547

High

477525

MYO1
Myosin-1

1

8

High-throughput

0.536

High

623791

MYO2
Myosin-2

1

4

High-throughput

0.536

High

646326

RAD53
Serine/threonine-protein kinase RAD53

1

9

High-throughput

0.536

High

713248

MYO4
Myosin-4

1

6

High-throughput

0.536

High

713290

ACT
Actin

1

8

High-throughput

0.536

High

713301

MYO5
Myosin-5

1

8

High-throughput

0.536

High

713275

RSC8
Chromatin structure-remodeling complex protein RSC8

2

0

High-throughput

0.528

High

713303

POB3
FACT complex subunit POB3

2

9

High-throughput

0.521

High

713315

SMT3
Ubiquitin-like protein SMT3

1

6

Small-scale

0.515

High

449083

CALM
Calmodulin

1

0

High-throughput

0.513

High

713255

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.513

High

713260

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.513

High

713264

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.513

High

713300

GYL1
Probable GTPase-activating protein GYL1

1

0

High-throughput

0.513

High

602354

PHO85
Cyclin-dependent protein kinase PHO85

1

10

High-throughput

0.501

High

692299

KCC1
Calcium/calmodulin-dependent protein kinase I

1

4

High-throughput

0.501

High

713244

DBF4
DDK kinase regulatory subunit DBF4

1

3

Small-scale

0.501

High

713250

IME2
Meiosis induction protein kinase IME2/SME1

1

14

Small-scale

0.501

High

713257

SLD2
DNA replication regulator SLD2

1

3

Small-scale

0.501

High

713277

DPB11
DNA replication regulator DPB11

1

4

Small-scale

0.501

High

562945

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.489

High

703764

CAPZA
F-actin-capping protein subunit alpha

1

2

High-throughput

0.489

High

713276

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.489

High

713286

MLC1
Myosin light chain 1

1

1

High-throughput

0.489

High

713307

CORO
Coronin-like protein

1

2

High-throughput

0.489

High

444746

SIR2
NAD-dependent histone deacetylase SIR2

1

13

Small-scale

0.481

High

448436

RAD52
DNA repair and recombination protein RAD52

1

2

Small-scale

0.481

High

647718

RFA1
Replication factor A protein 1

1

7

Small-scale

0.481

High

675314

RAD51
DNA repair protein RAD51

1

1

Small-scale

0.481

High

713265

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

3

Small-scale

0.481

High

713271

CSM2
Chromosome segregation in meiosis protein 2

1

3

Small-scale

0.481

High

713316

PSY3
Platinum sensitivity protein 3

1

3

Small-scale

0.481

High

364966

KPYK1
Pyruvate kinase 1

1

5

High-throughput

0.479

High

439276

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.479

High

448933

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.479

High

464566

PBS2
MAP kinase kinase PBS2

1

7

High-throughput

0.479

High

479255

CDC6
Cell division control protein 6

1

20

Small-scale

0.479

High

597404

EF3A
Elongation factor 3A

1

8

High-throughput

0.479

High

626635

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

694106

CDC15
Cell division control protein 15

1

2

High-throughput

0.479

High

706413

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

713247

HOG1
Mitogen-activated protein kinase HOG1

1

9

High-throughput

0.479

High

713253

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

713258

SPT10
Protein SPT10

1

3

High-throughput

0.479

High

713259

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.479

High

713283

UFD1
Ubiquitin fusion degradation protein 1

1

3

Small-scale

0.479

High

713292

SEN1
Helicase SEN1

1

3

Small-scale

0.479

High

713299

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

713304

CSM3
Chromosome segregation in meiosis protein 3

1

3

Small-scale

0.479

High

713306

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

713309

NOC3
Nucleolar complex-associated protein 3

1

2

Small-scale

0.479

High

713314

SCC1
Sister chromatid cohesion protein 1

1

3

High-throughput

0.479

High

713317

DBP10
ATP-dependent RNA helicase DBP10

1

13

High-throughput

0.479

High

594243

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

713245

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

713254

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

713279

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

381002

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

381439

H2B2
Histone H2B.2

1

20

High-throughput

0.445

High

386610

TBB
Tubulin beta chain

1

14

High-throughput

0.445

High

394318

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

427171

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

448147

HAP2
Transcriptional activator HAP2

1

3

High-throughput

0.445

High

453462

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.445

High

486072

TBA1
Tubulin alpha-1 chain

1

10

High-throughput

0.445

High

523281

HSP71
Heat shock protein SSA1

1

16

High-throughput

0.445

High

548756

MCM1
Pheromone receptor transcription factor

1

1

High-throughput

0.445

High

550033

RAP1
DNA-binding protein RAP1

1

1

High-throughput

0.445

High

592071

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.445

High

598824

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

5

High-throughput

0.445

High

603426

VATA
V-type proton ATPase catalytic subunit A

1

7

High-throughput

0.445

High

638979

VPS1
Vacuolar protein sorting-associated protein 1

1

1

High-throughput

0.445

High

645594

AFT1
Iron-regulated transcriptional activator AFT1

1

2

High-throughput

0.445

High

649927

SIN3
Transcriptional regulatory protein SIN3

1

1

High-throughput

0.445

High

671503

SWI4
Regulatory protein SWI4

1

8

High-throughput

0.445

High

690733

DPB3
DNA polymerase epsilon subunit C

1

1

Small-scale

0.445

High

713251

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

713256

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

713261

SET3
SET domain-containing protein 3

1

5

High-throughput

0.445

High

713266

IMB4
Importin subunit beta-4

1

2

High-throughput

0.445

High

713267

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

713273

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

713274

GCN20
Protein GCN20

1

7

High-throughput

0.445

High

713281

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.445

High

713291

H3
Histone H3

1

20

High-throughput

0.445

High

713293

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.445

High

713295

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

15

High-throughput

0.445

High

713298

GIS1
Transcriptional activator/repressor GIS1

1

9

High-throughput

0.445

High

713305

ARP9
Actin-like protein ARP9

1

8

High-throughput

0.445

High

713310

RSC58
Chromatin structure-remodeling complex protein RSC58

1

2

High-throughput

0.445

High

713319

CAF1A
Chromatin assembly factor 1 subunit A

1

6

High-throughput

0.445

High

713320

H2AZ
Histone H2A.Z

1

20

High-throughput

0.445

High

367920

ENO2
Enolase 2

1

5

High-throughput

0.437

High

368617

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.437

High

713287

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

150089

YA11B
Truncated transposon Ty1-A Gag-Pol polyprotein

1

0

High-throughput

0.426

High

713268

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

713297

ACL4
Assembly chaperone of RPL4

1

0

High-throughput

0.426

High

713302

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.426

High

575406

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.407

High

678854

CSM1
Monopolin complex subunit CSM1

1

0

Small-scale

0.269

Low

713308

LEC1
PX domain-containing protein LEC1

1

0

Small-scale

0.251

Low

713278

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025