HitPredict

Interactor 1: IL2 (P60568)
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Gene: IL2

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	7623820, 18045535
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0043066 - negative regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 153 Hs			1 551
+	Mm
		381343 IL2_MOUSE (1-151): 6.75e-71: 212: 57.23		TF65_MOUSE (1-551): 0: 577: 87.88
+	Hs
		891382 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		REL_HUMAN (12-523): 3.56e-165: 484: 41.64
+	Hs
		891386 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		NFAC3_HUMAN (4-522): 1.3e-119: 380: 19.26
+	Hs
		891387 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		NFAC2_HUMAN (4-527): 1.26e-110: 353: 18.97
+	Mm
		381344 IL2_MOUSE (1-151): 6.75e-71: 212: 57.23		NFAC2_MOUSE (4-527): 2.76e-119: 375: 19.37
+	Hs
		317942 IL2_HUMAN (1-153): 1.29e-80: 236: 100.00		NFAC1_HUMAN (1-503): 2.8e-93: 307: 18.89