HitPredict

Interactor 1: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Interactor 2: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	21068446, 34195792, 23370391
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-rbx1
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 165 Hs			1 108
+	Hs
		921482 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00
+	Hs
		849303 UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03		RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00
+	Mm
		895979 UB2D1_MOUSE (4-164): 3.3e-73: 217: 36.03		RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00
+	Hs
		919703 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00
+	Mm
		919923 UB2D2_MOUSE (4-164): 5.65e-73: 217: 36.03		RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00
+	Hs
		895771 UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78		RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00
+	Mm
		895973 UB2D3_MOUSE (4-164): 1.16e-71: 213: 34.78		RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00
+	Mm
		891455 UB2G2_MOUSE (1-165): 5.88e-71: 212: 100.00		RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00
+	Ce
		715111 UBC2_CAEEL (4-164): 2.9e-73: 218: 34.78		RBX1_CAEEL (2-108): 1.48e-44: 141: 79.44
+	Sc
		549843 UBC4_YEAST (1-163): 4.52e-71: 212: 31.90		RBX1_YEAST (17-107): 8.73e-38: 125: 64.84
+	Hs
		1354003 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00
+	Hs
		849472 UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03		RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00
+	Hs
		919890 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00
+	Ce
		715108 UBC2_CAEEL (4-164): 2.9e-73: 218: 34.78		APC11_CAEEL (5-105): 1.28e-29: 104: 28.97
+	Hs
		895936 UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78		RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00
+	Hs
		849463 UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03		APC11_HUMAN (20-105): 8.33e-28: 98.6: 37.08
+	Hs
		919882 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		APC11_HUMAN (20-105): 8.33e-28: 98.6: 37.08
+	Hs
		895932 UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78		APC11_HUMAN (20-105): 8.33e-28: 98.6: 37.08
+	Sc
		549847 UBC4_YEAST (1-163): 4.52e-71: 212: 31.90		APC11_YEAST (20-105): 5.39e-26: 96.3: 26.17
+	Sp
		804461 UBC4_SCHPO (4-163): 5.27e-71: 212: 34.38		APC11_SCHPO (20-104): 3.04e-25: 92.5: 31.46