HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: COTL1 (Q14019)
Coactosin-like protein
Gene: COTL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11583571
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005884 - actin filament GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 142
+	Hs
		1084964 ACTBL_HUMAN (2-375): 0: 735: 91.71		DREB_HUMAN (1-132): 8.41e-44: 153: 17.78
+	Hs
		892099 ACTB_HUMAN (1-375): 0: 603: 100.00		DBNL_HUMAN (1-142): 1.29e-53: 176: 23.81
+	Mm
		892211 ACTB_MOUSE (1-375): 0: 603: 100.00		COTL1_MOUSE (1-142): 1.12e-54: 169: 95.07
+	Hs
		929858 ACTG_HUMAN (1-375): 0: 601: 98.93		COTL1_HUMAN (1-142): 8.17e-55: 170: 100.00
+	Mm
		929806 ACTG_MOUSE (1-375): 0: 601: 98.93		COTL1_MOUSE (1-142): 1.12e-54: 169: 95.07
+	Hs
		932439 ACTC_HUMAN (2-375): 0: 592: 94.12		DBNL_HUMAN (1-142): 1.29e-53: 176: 23.81
+	Hs
		932976 ACTS_HUMAN (2-375): 0: 592: 93.58		COTL1_HUMAN (1-142): 8.17e-55: 170: 100.00
+	Ce
		501469 ACT2_CAEEL (2-375): 0: 600: 98.13		Q9XUT0_CAEEL (1-142): 9.79e-45: 156: 21.38
+	Hs
		891799 ACTB_HUMAN (1-375): 0: 603: 100.00		DREB_HUMAN (1-132): 8.41e-44: 153: 17.78
+	Hs
		929879 ACTG_HUMAN (1-375): 0: 601: 98.93		DREB_HUMAN (1-132): 8.41e-44: 153: 17.78
+	Hs
		932187 ACTC_HUMAN (2-375): 0: 592: 94.12		DREB_HUMAN (1-132): 8.41e-44: 153: 17.78
+	Hs
		915391 ACTA_HUMAN (2-375): 0: 591: 94.12		DREB_HUMAN (1-132): 8.41e-44: 153: 17.78
+	Sc
		551386 ACT_YEAST (1-375): 0: 591: 88.80		ABP1_YEAST (1-141): 1.3e-38: 139: 14.58