HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: RHG12 (Q8IWW6)
Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)
Gene: ARHGAP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RhoGAP
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 846
+	Hs
		1122443 ACTBL_HUMAN (2-375): 0: 735: 91.71		RHG12_HUMAN (1-846): 0: 802: 100.00
+	Hs
		929916 ACTG_HUMAN (1-375): 0: 601: 98.93		RHG12_HUMAN (1-846): 0: 802: 100.00
+	Hs
		891856 ACTB_HUMAN (1-375): 0: 603: 100.00		RHG27_HUMAN (11-845): 3.56e-169: 514: 32.45
+	Hs
		929907 ACTG_HUMAN (1-375): 0: 601: 98.93		RHG27_HUMAN (11-845): 3.56e-169: 514: 32.45
+	Hs
		787164 POTEE_HUMAN (1-375): 0: 736: 92.00		RHG25_HUMAN (481-846): 2.83e-69: 243: 19.58
+	Hs
		891826 ACTB_HUMAN (1-375): 0: 603: 100.00		RHG21_HUMAN (78-846): 3.01e-97: 336: 21.24
+	Hs
		891744 ACTB_HUMAN (1-375): 0: 603: 100.00		MYO9B_HUMAN (52-840): 3.46e-94: 327: 17.69
+	Hs
		112131 ACTG_HUMAN (1-375): 0: 601: 98.93		M0R0P8_HUMAN (52-840): 3.43e-94: 327: 17.69
+	Hs
		929850 ACTG_HUMAN (1-375): 0: 601: 98.93		MYO9B_HUMAN (52-840): 3.46e-94: 327: 17.69
+	Hs
		64678 ACTB_HUMAN (1-375): 0: 603: 100.00		RHG32_HUMAN (603-844): 6.16e-73: 263: 30.00
+	Hs
		64690 ACTG_HUMAN (1-375): 0: 601: 98.93		RHG32_HUMAN (603-844): 6.16e-73: 263: 30.00
+	Hs
		892060 ACTB_HUMAN (1-375): 0: 603: 100.00		RHG35_HUMAN (392-844): 4.72e-71: 258: 19.72
+	Hs
		253332 ACTB_HUMAN (1-375): 0: 603: 100.00		SRGP2_HUMAN (534-845): 1.45e-69: 251: 22.40
+	Hs
		932401 ACTC_HUMAN (2-375): 0: 592: 94.12		RHG35_HUMAN (392-844): 4.72e-71: 258: 19.72
+	Hs
		891894 ACTB_HUMAN (1-375): 0: 603: 100.00		RHG24_HUMAN (566-846): 3.02e-69: 245: 23.83
+	Hs
		929924 ACTG_HUMAN (1-375): 0: 601: 98.93		RHG24_HUMAN (566-846): 3.02e-69: 245: 23.83
+	Dm
		501569 ACT1_DROME (2-375): 0: 598: 98.13		Q9W4A9_DROME (635-844): 8.31e-66: 230: 29.11