HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0030027 - lamellipodium GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 508
+	Hs
		929923 ACTG_HUMAN (1-375): 0: 601: 98.93		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		932254 ACTC_HUMAN (2-375): 0: 592: 94.12		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		892072 ACTB_HUMAN (1-375): 0: 603: 100.00		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		930026 ACTG_HUMAN (1-375): 0: 601: 98.93		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		203220 ACTC_HUMAN (2-375): 0: 592: 94.12		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Hs
		891762 ACTB_HUMAN (1-375): 0: 603: 100.00		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		929863 ACTG_HUMAN (1-375): 0: 601: 98.93		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		891770 ACTB_HUMAN (1-375): 0: 603: 100.00		LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28
+	Hs
		932154 ACTC_HUMAN (2-375): 0: 592: 94.12		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Mm
		915552 ACTA_MOUSE (2-375): 0: 591: 94.12		LASP1_MOUSE (285-503): 1.88e-32: 126: 19.73
+	Hs
		892099 ACTB_HUMAN (1-375): 0: 603: 100.00		DBNL_HUMAN (316-503): 2.32e-17: 86.1: 20.53
+	Hs
		892142 ACTB_HUMAN (1-375): 0: 603: 100.00		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		932439 ACTC_HUMAN (2-375): 0: 592: 94.12		DBNL_HUMAN (316-503): 2.32e-17: 86.1: 20.53
+	Hs
		235496 ACTS_HUMAN (2-375): 0: 592: 93.58		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Hs
		932478 ACTC_HUMAN (2-375): 0: 592: 94.12		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		891821 ACTB_HUMAN (1-375): 0: 603: 100.00		SH319_HUMAN (446-503): 2.42e-10: 65.1: 36.21