Protein: UB2E3
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)

Gene: UB2E3, UBE2E3
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q969T4

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1282336

RNF5
E3 ubiquitin-protein ligase RNF5

7

20

Small-scale

0.965

High

1282326

OTUB1
Ubiquitin thioesterase OTUB1

7

11

Small-scale

0.961

High

1282323

RNF25
E3 ubiquitin-protein ligase RNF25

6

14

Small-scale

0.956

High

175703

TRI18
E3 ubiquitin-protein ligase Midline-1

6

20

Small-scale

0.951

High

1282318

UB2E3
Ubiquitin-conjugating enzyme E2 E3

4

17

Small-scale

0.888

High

1235226

RNF10
E3 ubiquitin-protein ligase RNF10

3

20

High-throughput

0.875

High

1169175

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.867

High

1282346

RN167
E3 ubiquitin-protein ligase RNF167

3

20

Small-scale

0.867

High

749752

BRCA1
Breast cancer type 1 susceptibility protein

3

20

Small-scale

0.865

High

1282325

CHFR
E3 ubiquitin-protein ligase CHFR

3

20

High-throughput

0.861

High

1282333

RING2
E3 ubiquitin-protein ligase RING2

3

20

High-throughput

0.861

High

1282368

RN115
E3 ubiquitin-protein ligase RNF115

3

20

High-throughput

0.861

High

1138036

RN220
E3 ubiquitin-protein ligase RNF220

3

7

High-throughput

0.858

High

1282320

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

3

20

Small-scale

0.852

High

125629

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

20

Small-scale

0.849

High

317679

CNOT4
CCR4-NOT transcription complex subunit 4

3

11

Small-scale

0.847

High

607129

UBA1
Ubiquitin-like modifier-activating enzyme 1

3

20

Small-scale

0.845

High

962909

MDM2
E3 ubiquitin-protein ligase Mdm2

3

14

Small-scale

0.845

High

1282332

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.845

High

1282365

CHIP
E3 ubiquitin-protein ligase CHIP

3

14

Small-scale

0.845

High

1204900

TRI50
E3 ubiquitin-protein ligase TRIM50

3

20

Small-scale

0.845

High

1282328

RN185
E3 ubiquitin-protein ligase RNF185

5

20

High-throughput

0.834

High

1282359

RNF14
E3 ubiquitin-protein ligase RNF14

2

20

Small-scale

0.812

High

475124

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

High-throughput

0.811

High

1108530

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.811

High

1282352

TOPRS
E3 ubiquitin-protein ligase Topors

2

6

High-throughput

0.811

High

1282366

RNF11
RING finger protein 11

2

20

High-throughput

0.811

High

941269

RNF4
E3 ubiquitin-protein ligase RNF4

2

20

Small-scale

0.800

High

476155

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

1281989

TRI63
E3 ubiquitin-protein ligase TRIM63

2

20

Small-scale

0.767

High

1282363

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

20

Small-scale

0.755

High

1282362

HERC5
E3 ISG15--protein ligase HERC5

2

20

Small-scale

0.743

High

1282350

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.722

High

610469

CBL
E3 ubiquitin-protein ligase CBL

1

11

Small-scale

0.713

High

207566

RNF13
E3 ubiquitin-protein ligase RNF13

1

20

High-throughput

0.698

High

312639

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

988005

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.698

High

1148163

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.698

High

1160836

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

20

High-throughput

0.698

High

1170314

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

1204805

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.698

High

1205108

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1238392

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

20

High-throughput

0.698

High

1242072

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

20

High-throughput

0.698

High

1254705

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1282327

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.698

High

1282343

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.698

High

1282345

TRIM2
Tripartite motif-containing protein 2

1

20

High-throughput

0.698

High

1282357

RN181
E3 ubiquitin-protein ligase RNF181

1

20

High-throughput

0.698

High

1282369

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.698

High

1282342

TRI54
Tripartite motif-containing protein 54

2

20

Small-scale

0.687

High

282705

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.680

High

1282361

IPO11
Importin-11

1

3

Small-scale

0.680

High

1185070

DET1
DET1 homolog

3

3

Small-scale

0.667

High

228283

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

801748

RAGP1
Ran GTPase-activating protein 1

1

2

Small-scale

0.647

High

865068

TTC3
E3 ubiquitin-protein ligase TTC3

1

14

Small-scale

0.647

High

921379

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

1041136

CUL1
Cullin-1

1

16

Small-scale

0.647

High

1042223

CUL3
Cullin-3

1

16

Small-scale

0.647

High

1043149

CUL4A
Cullin-4A

1

16

Small-scale

0.647

High

1125824

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

20

Small-scale

0.647

High

1282324

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1282329

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

586902

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.628

High

1282367

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

2

High-throughput

0.628

High

1023522

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.625

High

1262512

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.625

High

1282321

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.625

High

1282364

RN150
RING finger protein 150

1

20

High-throughput

0.625

High

1023307

TRI32
E3 ubiquitin-protein ligase TRIM32

1

20

Small-scale

0.621

High

1245509

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

20

Small-scale

0.621

High

1282338

RN126
E3 ubiquitin-protein ligase RNF126

1

20

High-throughput

0.621

High

1282347

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

868665

ATX1
Ataxin-1

2

1

High-throughput

0.620

High

245625

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

4

Small-scale

0.618

High

1282344

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

5

Small-scale

0.618

High

1282356

DTL
Denticleless protein homolog

1

9

Small-scale

0.618

High

307269

RCBT2
RCC1 and BTB domain-containing protein 2

3

20

Small-scale

0.612

High

781150

ETV5
ETS translocation variant 5

2

2

High-throughput

0.611

High

1253589

FBX25
F-box only protein 25

2

1

High-throughput

0.611

High

1282337

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

20

High-throughput

0.611

High

1282331

RDH12
Retinol dehydrogenase 12

3

1

High-throughput

0.609

High

1065151

DAZP2
DAZ-associated protein 2

2

2

High-throughput

0.606

High

1282339

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

1282351

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1282355

PGPI
Pyroglutamyl-peptidase 1

2

1

High-throughput

0.606

High

1282341

PECR
Peroxisomal trans-2-enoyl-CoA reductase

2

0

High-throughput

0.602

High

70479

B2RDW1
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.590

High

304280

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.590

High

1137415

Q5U5U6
Epididymis secretory protein Li 50

1

20

High-throughput

0.590

High

1192156

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.590

High

1282319

WBP2
WW domain-binding protein 2

2

0

High-throughput

0.580

High

1245284

PJA1
E3 ubiquitin-protein ligase Praja-1

1

20

Small-scale

0.579

High

1282349

RC3H2
Roquin-2

1

9

Small-scale

0.579

High

1081240

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.561

High

1281137

NKD2
Protein naked cuticle homolog 2

2

1

High-throughput

0.558

High

1282322

ARRD3
Arrestin domain-containing protein 3

2

7

High-throughput

0.553

High

1025889

TADBP
TAR DNA-binding protein 43

1

2

Small-scale

0.552

High

791837

HD
Huntingtin

1

1

High-throughput

0.541

High

1200256

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.541

High

1273779

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.536

High

1282335

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

Small-scale

0.529

High

1282360

SAE2
SUMO-activating enzyme subunit 2

1

20

Small-scale

0.516

High

231659

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

388636

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

449788

HMGB1
High mobility group protein B1

1

1

Small-scale

0.508

High

214336

SPOP
Speckle-type POZ protein

1

7

Small-scale

0.501

High

1176255

ASXL2
Putative Polycomb group protein ASXL2

1

2

Small-scale

0.501

High

1242535

RCBT1
RCC1 and BTB domain-containing protein 1

1

20

Small-scale

0.501

High

1282334

BARD1
BRCA1-associated RING domain protein 1

1

11

Small-scale

0.501

High

1282358

KLH42
Kelch-like protein 42

1

6

Small-scale

0.501

High

893438

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

135036

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

301956

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.481

High

536965

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.481

High

902843

UFM1
Ubiquitin-fold modifier 1

1

5

High-throughput

0.481

High

1216680

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

Small-scale

0.481

High

1156371

ZN746
Zinc finger protein 746

1

0

Small-scale

0.480

High

208176

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.479

High

244756

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

504528

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

582423

NUCL
Nucleolin

1

2

High-throughput

0.479

High

807796

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

1082317

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1282340

DDA1
DET1- and DDB1-associated protein 1

1

2

Small-scale

0.479

High

1282354

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

6

Small-scale

0.457

High

298699

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.457

High

321424

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.457

High

932816

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.457

High

1049863

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.457

High

1282353

CUED1
CUE domain-containing protein 1

1

2

High-throughput

0.439

High

842600

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.438

High

899535

MGN
Protein mago nashi homolog

1

0

High-throughput

0.438

High

1256601

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.438

High

65048

A8CGI2
Ubiquitin C

1

2

High-throughput

0.417

High

1234599

ARRD1
Arrestin domain-containing protein 1

1

7

High-throughput

0.417

High

1172840

CC121
Coiled-coil domain-containing protein 121

2

0

High-throughput

0.318

High

1282330

MERB1
bMERB domain-containing protein 1

1

0

High-throughput

0.279

Low

1282348

FBRS
Probable fibrosin-1

1

0

High-throughput

0.279

Low

281800

WFS1
Wolframin

1

0

High-throughput

0.268

Low

363635

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

1244114

A2012
Putative ankyrin repeat domain-containing protein 20A12 pseudogene

1

0

High-throughput

0.238

Low

1282370

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024