HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: ARP8 (Q9H981)
Actin-related protein 8 (hArp8) (INO80 complex subunit N)
Gene: ACTR8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045893 - positive regulation of DNA-templated transcription and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 624
+	Hs
		891845 POTEE_HUMAN (1-375): 0: 736: 92.00		ACTB_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		929902 POTEE_HUMAN (1-375): 0: 736: 92.00		ACTG_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		891818 ACTBL_HUMAN (2-375): 0: 735: 91.71		ACTB_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		915402 ACTBL_HUMAN (2-375): 0: 735: 91.71		ACTA_HUMAN (401-620): 8.77e-54: 189: 16.29
+	Hs
		932195 ACTBL_HUMAN (2-375): 0: 735: 91.71		ACTC_HUMAN (401-620): 8.77e-54: 189: 16.29
+	Hs
		474804 POTEI_HUMAN (1-375): 0: 731: 91.20		ACTB_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		474805 POTEI_HUMAN (1-375): 0: 731: 91.20		ACTC_HUMAN (401-620): 8.77e-54: 189: 16.29
+	Hs
		60342 ACTBL_HUMAN (2-375): 0: 735: 91.71		POTEF_HUMAN (477-620): 6.97e-48: 183: 20.69
+	Hs
		891654 ACTB_HUMAN (1-375): 0: 603: 100.00		ARP2_HUMAN (136-467): 4.48e-77: 252: 19.49
+	Gg
		891646 ACTB_CHICK (1-375): 0: 603: 100.00		ACTB_CHICK (401-620): 3.24e-54: 191: 16.29
+	Hs
		891648 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTB_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		891675 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTG_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		929883 Q1KLZ0_HUMAN (1-375): 0: 603: 100.00		ACTG_HUMAN (401-620): 3.24e-54: 191: 16.29
+	Hs
		891666 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTA_HUMAN (401-620): 8.77e-54: 189: 16.29
+	Hs
		891680 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTC_HUMAN (401-620): 8.77e-54: 189: 16.29
+	Hs
		891681 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTS_HUMAN (401-620): 1.91e-53: 189: 16.29
+	Hs
		891676 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTH_HUMAN (401-620): 6.02e-53: 187: 16.29
+	Hs
		474872 ACTB_HUMAN (1-375): 0: 603: 100.00		POTEJ_HUMAN (477-620): 7.31e-48: 182: 20.69