HitPredict

Interactor 1: PRPS1 (P60891)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
Gene: PRPS1

Interactor 2: KPRA (Q14558)
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)
Gene: PRPSAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.985

The method score is based on:

Property Details
Experiments 9366267, 25416956, 26186194, 16189514, 26496610, 25910212, 28514442, 32296183, 33961781, 34349018, 37071682, 31515488, unassigned1304
Identification Methods pull down, two hybrid, affinity chromatography technology, cross-linking study, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid bait and prey pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 2 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 318
Hs

1 356
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Last updated: 15 Jul 2024