Protein: UBP8
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (SAGA complex subunit UBP8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

Gene: UBP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P50102

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

893317

SGF73
SAGA complex subunit SGF73

15

9

Small-scale

0.983

High

893360

SUS1
SAGA complex subunit SUS1

15

5

Small-scale

0.982

High

793952

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

10

17

Small-scale

0.969

High

893313

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

6

14

Small-scale

0.939

High

893332

SGF11
SAGA complex subunit SGF11

13

0

Small-scale

0.929

High

509637

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

20

Small-scale

0.866

High

762987

SPT7
SAGA complex subunit SPT7

18

20

Small-scale

0.763

High

893328

ADA2
SAGA complex subunit ADA2

17

9

Small-scale

0.763

High

893333

GCN5
Histone acetyltransferase GCN5

17

20

Small-scale

0.763

High

893352

HFI1
SAGA complex subunit HFI1

11

1

Small-scale

0.754

High

893316

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

10

3

Small-scale

0.753

High

738162

NGG1
SAGA complex subunit NGG1

10

3

Small-scale

0.751

High

893335

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

10

4

Small-scale

0.751

High

449461

SPT3
SAGA complex subunit SPT3

10

3

Small-scale

0.751

High

805196

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

8

9

Small-scale

0.747

High

676655

SGF29
SAGA complex subunit SGF29

8

5

Small-scale

0.746

High

893351

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

8

1

Small-scale

0.746

High

893341

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

7

5

Small-scale

0.740

High

807243

SPT8
SAGA complex subunit SPT8

11

0

Small-scale

0.723

High

893314

SPT20
SAGA complex subunit SPT20

10

0

Small-scale

0.720

High

750732

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.691

High

402054

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

2

Small-scale

0.672

High

430885

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

High-throughput

0.618

High

734151

EF2
Elongation factor 2

1

4

High-throughput

0.618

High

381167

H2B1
Histone H2B.1

2

20

Small-scale

0.602

High

381566

H2B2
Histone H2B.2

2

20

Small-scale

0.602

High

419805

H2A2
Histone H2A.2

2

18

High-throughput

0.588

High

734443

BTAF1
TATA-binding protein-associated factor MOT1

2

12

Small-scale

0.584

High

436462

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

19

High-throughput

0.575

High

812865

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

17

High-throughput

0.575

High

822417

PRS4
26S proteasome regulatory subunit 4 homolog

1

6

High-throughput

0.575

High

448764

SNF1
Carbon catabolite-derepressing protein kinase

1

7

Small-scale

0.561

High

524524

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.552

High

671665

SCJ1
DnaJ-related protein SCJ1

2

6

High-throughput

0.552

High

393020

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.536

High

643273

BAS1
Myb-like DNA-binding protein BAS1

1

1

High-throughput

0.536

High

666502

DBP2
ATP-dependent RNA helicase DBP2

1

7

High-throughput

0.536

High

694591

SPT5
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

727175

HS104
Heat shock protein 104

1

1

High-throughput

0.536

High

739892

RPD3
Histone deacetylase RPD3

1

10

High-throughput

0.536

High

740191

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.536

High

803619

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.536

High

811350

CAJ1
Protein CAJ1

1

7

High-throughput

0.536

High

893315

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.536

High

893339

RCO1
Transcriptional regulatory protein RCO1

1

14

High-throughput

0.536

High

893347

SUB2
ATP-dependent RNA helicase SUB2

1

7

High-throughput

0.536

High

893350

NEW1
[NU+] prion formation protein 1

1

4

High-throughput

0.536

High

737746

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

3

High-throughput

0.514

High

836060

COPB2
Coatomer subunit beta'

1

11

High-throughput

0.514

High

893320

COPA
Coatomer subunit alpha

1

7

High-throughput

0.514

High

893358

NOP58
Nucleolar protein 58

1

4

High-throughput

0.514

High

358270

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.513

High

368246

TRP
Tryptophan synthase

1

0

High-throughput

0.513

High

448191

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

813639

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.513

High

893324

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.513

High

893344

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.513

High

437938

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.501

High

444859

SIR3
Regulatory protein SIR3

1

2

High-throughput

0.489

High

518334

IF4A
ATP-dependent RNA helicase eIF4A

1

8

High-throughput

0.489

High

575601

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

4

High-throughput

0.489

High

577322

NSP1
Nucleoporin NSP1

1

6

High-throughput

0.489

High

579727

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.489

High

597505

EF3A
Elongation factor 3A

1

3

High-throughput

0.489

High

603510

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.489

High

626810

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.489

High

634258

NUP1
Nucleoporin NUP1

1

8

High-throughput

0.489

High

656331

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

4

High-throughput

0.489

High

746742

KPR1
Ribose-phosphate pyrophosphokinase 1

1

3

High-throughput

0.489

High

779427

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.489

High

793337

SYG
Glycine--tRNA ligase 1, mitochondrial

1

1

High-throughput

0.489

High

802572

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.489

High

810852

TCPG
T-complex protein 1 subunit gamma

1

6

High-throughput

0.489

High

815175

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

4

High-throughput

0.489

High

844415

TCPH
T-complex protein 1 subunit eta

1

6

High-throughput

0.489

High

893325

ACAC
Acetyl-CoA carboxylase

1

3

High-throughput

0.489

High

893329

NU116
Nucleoporin NUP116/NSP116

1

5

High-throughput

0.489

High

893349

HRK1
Serine/threonine-protein kinase HRK1

1

5

High-throughput

0.489

High

408482

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

822226

SECU
Securin

1

0

Small-scale

0.480

High

707616

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

744319

CHD1
Chromo domain-containing protein 1

1

11

Small-scale

0.479

High

779287

CENPA
Histone H3-like centromeric protein CSE4

1

8

Small-scale

0.479

High

800731

RCK1
Serine/threonine-protein kinase RCK1

1

5

High-throughput

0.479

High

836691

GSHR
Glutathione reductase

1

1

High-throughput

0.479

High

893323

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

893355

YRA1
RNA annealing protein YRA1

1

4

Small-scale

0.479

High

598890

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.464

High

314891

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

736679

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

743633

RTG2
Retrograde regulation protein 2

1

0

Small-scale

0.458

High

763937

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

764117

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

865672

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

359035

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.445

High

452747

ADR1
Regulatory protein ADR1

1

3

High-throughput

0.445

High

459128

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.445

High

470559

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

481685

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

504605

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

534068

HSF
Heat shock transcription factor

1

2

High-throughput

0.445

High

545522

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

584927

TRM1
tRNA

1

1

High-throughput

0.445

High

597206

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

614834

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

6

High-throughput

0.445

High

632187

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.445

High

670919

SIS1
Protein SIS1

1

5

High-throughput

0.445

High

679862

CDC48
Cell division control protein 48

1

4

High-throughput

0.445

High

692588

NSR1
Nuclear localization sequence-binding protein

1

4

High-throughput

0.445

High

725926

PSK1
Serine/threonine-protein kinase PSK1

1

9

High-throughput

0.445

High

741954

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

754165

MSN2
Zinc finger protein MSN2

1

5

High-throughput

0.445

High

754221

MSN4
Zinc finger protein MSN4

1

5

High-throughput

0.445

High

763463

MDJ1
DnaJ homolog 1, mitochondrial

1

7

High-throughput

0.445

High

779079

EF1G2
Elongation factor 1-gamma 2

1

3

High-throughput

0.445

High

793436

ATR
Serine/threonine-protein kinase MEC1

1

9

High-throughput

0.445

High

850546

RSC8
Chromatin structure-remodeling complex protein RSC8

1

9

High-throughput

0.445

High

874245

CLA4
Serine/threonine-protein kinase CLA4

1

5

High-throughput

0.445

High

893330

IMA1
Importin subunit alpha

1

4

High-throughput

0.445

High

893336

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.445

High

893354

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

893356

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.445

High

893357

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.445

High

893353

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

2

High-throughput

0.437

High

553547

PDR1
Transcription factor PDR1

1

0

High-throughput

0.426

High

564664

STE12
Protein STE12

1

0

High-throughput

0.426

High

572618

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

590674

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

625967

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.426

High

626520

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.426

High

645619

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

649987

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

677689

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.426

High

893331

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.426

High

893337

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

893343

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.426

High

359500

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.407

High

383156

RLA4
Large ribosomal subunit protein P2B

1

2

High-throughput

0.407

High

386782

TBB
Tubulin beta chain

1

8

High-throughput

0.407

High

417143

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.407

High

427357

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

427587

RLA1
Large ribosomal subunit protein P1A

1

2

High-throughput

0.407

High

427719

RLA2
Large ribosomal subunit protein P2A

1

2

High-throughput

0.407

High

445354

CDC31
Cell division control protein 31

1

8

High-throughput

0.407

High

450613

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.407

High

475130

CYAA
Adenylate cyclase

1

6

High-throughput

0.407

High

477591

MYO1
Myosin-1

1

7

High-throughput

0.407

High

510647

HSP77
Import motor subunit, mitochondrial

1

6

High-throughput

0.407

High

528843

RLA3
Large ribosomal subunit protein P1B

1

2

High-throughput

0.407

High

569818

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.407

High

599049

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.407

High

644812

CLH
Clathrin heavy chain

1

2

High-throughput

0.407

High

700259

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

2

High-throughput

0.407

High

738404

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.407

High

738487

NUP2
Nucleoporin NUP2

1

5

High-throughput

0.407

High

738595

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.407

High

739693

SPT16
FACT complex subunit SPT16

1

3

High-throughput

0.407

High

760606

TSA1
Peroxiredoxin TSA1

1

1

High-throughput

0.407

High

811121

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.407

High

821022

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

13

High-throughput

0.407

High

823621

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.407

High

865000

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.407

High

868427

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.407

High

893319

YG5B
Uncharacterized RNA-binding protein YGR250C

1

2

High-throughput

0.407

High

893321

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.407

High

893322

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.407

High

893327

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.407

High

893334

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.407

High

893342

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

10

High-throughput

0.407

High

893348

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.407

High

893338

RBA50
RNA polymerase II-associated protein RBA50

2

0

High-throughput

0.318

High

553632

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.279

Low

575479

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

701722

URA7
CTP synthase 1

1

0

High-throughput

0.279

Low

893318

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.279

Low

893326

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.279

Low

893340

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.279

Low

893345

CSR1
Phosphatidylinositol transfer protein CSR1

1

0

High-throughput

0.279

Low

449148

CALM
Calmodulin

1

0

High-throughput

0.232

Low

511986

RS30B
Small ribosomal subunit protein eS30B

1

0

High-throughput

0.232

Low

585178

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low

631967

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low

639449

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.232

Low

672329

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.232

Low

703778

CAPZA
F-actin-capping protein subunit alpha

1

0

High-throughput

0.232

Low

794359

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.232

Low

863648

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

893346

MRL1
Mannose 6-phosphate receptor-like protein 1

1

0

High-throughput

0.232

Low

893359

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025