HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: TBD2A (Q9BYX2)
TBC1 domain family member 2A (Armus) (Prostate antigen recognized and identified by SEREX 1) (PARIS-1)
Gene: TBC1D2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	21311754
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, RabGAP-TBC~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 928
+	Hs
		925738 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TBD2B_HUMAN (45-907): 0: 584: 39.57
+	Hs
		951462 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		TBD2B_HUMAN (45-907): 0: 584: 39.57
+	Ce
		975574 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		Q23419_CAEEL (13-896): 5.3e-179: 543: 27.36
+	Hs
		925616 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		PKHA4_HUMAN (33-604): 1.11e-115: 373: 15.52
+	Hs
		894431 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		PKHA4_HUMAN (33-604): 1.11e-115: 373: 15.52
+	Hs
		951339 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		PKHA4_HUMAN (33-604): 1.11e-115: 373: 15.52
+	Hs
		900902 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		PKHA4_HUMAN (33-604): 1.11e-115: 373: 15.52
+	Hs
		564554 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		TB10B_HUMAN (499-922): 3.6e-84: 290: 24.94
+	Hs
		564635 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		1117432 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		TB10B_HUMAN (499-922): 3.6e-84: 290: 24.94
+	Hs
		232655 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TBCD4_HUMAN (433-926): 2.48e-84: 298: 20.62
+	Hs
		925323 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		TB10B_HUMAN (499-922): 3.6e-84: 290: 24.94
+	Hs
		321304 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		TBCD8_HUMAN (543-925): 3.51e-80: 284: 24.69
+	Hs
		1270182 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		925494 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		321279 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		TBCD8_HUMAN (543-925): 3.51e-80: 284: 24.69
+	Hs
		894279 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		951204 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		900761 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39
+	Hs
		545541 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		US6NL_HUMAN (521-892): 1.64e-80: 280: 21.39