HitPredict

Interactor 1: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: SIK2 (Q9H0K1)
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Gene: SIK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	33947818
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 926
+	Hs
		564418 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		647958 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		564584 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		647868 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		647856 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		647872 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		647858 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		545213 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		1183120 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		436165 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Hs
		925384 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		647855 RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32		MARK3_HUMAN (8-677): 2.57e-152: 469: 30.77
+	Rn
		871319 RAC1_RAT (1-191): 1.75e-84: 249: 70.31		AAPK1_RAT (3-526): 7.76e-149: 453: 30.74
+	Hs
		894157 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		951102 RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Rn
		871208 RHOA_RAT (5-191): 9.99e-82: 242: 53.48		AAPK1_RAT (3-526): 7.76e-149: 453: 30.74
+	Hs
		900617 RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		545461 RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		436371 RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41		MARK2_HUMAN (1-673): 4.94e-146: 454: 31.29
+	Hs
		894319 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		MARK4_HUMAN (15-497): 6.09e-140: 436: 41.02