Protein: VTNC
Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]

Gene: VTNC, VTN
Organism: Homo sapiens
Interactions: 162
UniProt ID: P04004

Gene Ontology (top 5):
GO:0005044 - scavenger receptor activity
GO:0005178 - integrin binding
GO:0005201 - extracellular matrix structural constituent
GO:0005518 - collagen binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

399523

PAI1
Plasminogen activator inhibitor 1

3

2

Small-scale

0.834

High

399542

ITB5
Integrin beta-5

4

4

Small-scale

0.691

High

399568

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

2

Small-scale

0.675

High

399622

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

3

1

High-throughput

0.662

High

399517

VTNC
Vitronectin

1

4

Small-scale

0.647

High

399525

ITAV
Integrin alpha-V

3

5

Small-scale

0.641

High

240448

PRKN
E3 ubiquitin-protein ligase parkin

3

5

High-throughput

0.640

High

399634

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

4

4

High-throughput

0.637

High

275480

RTN2
Reticulon-2

2

1

High-throughput

0.628

High

399592

KTN1
Kinectin

2

2

High-throughput

0.628

High

399573

CUL7
Cullin-7

3

3

High-throughput

0.609

High

399606

DLG3
Disks large homolog 3

2

1

High-throughput

0.606

High

399588

GRIN1
G protein-regulated inducer of neurite outgrowth 1

3

1

High-throughput

0.604

High

399628

TARA
TRIO and F-actin-binding protein

3

1

High-throughput

0.604

High

399639

RAI14
Ankycorbin

3

1

High-throughput

0.604

High

399521

A4
Amyloid-beta precursor protein

2

4

Small-scale

0.602

High

399547

1433T
14-3-3 protein theta

2

0

High-throughput

0.576

High

399540

HXB9
Homeobox protein Hox-B9

2

1

High-throughput

0.574

High

399614

NEK1
Serine/threonine-protein kinase Nek1

2

3

High-throughput

0.574

High

399623

WDR33
pre-mRNA 3' end processing protein WDR33

2

5

High-throughput

0.574

High

399642

RNF14
E3 ubiquitin-protein ligase RNF14

2

5

High-throughput

0.574

High

399643

ARMX3
Armadillo repeat-containing X-linked protein 3

2

1

High-throughput

0.574

High

399647

ZN777
Zinc finger protein 777

2

1

High-throughput

0.574

High

399577

DLG2
Disks large homolog 2

2

1

High-throughput

0.553

High

399637

SNTG1
Gamma-1-syntrophin

2

3

High-throughput

0.553

High

399535

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.549

High

132981

MATN2
Matrilin-2

1

11

High-throughput

0.536

High

210672

KLK10
Kallikrein-10

1

7

High-throughput

0.536

High

399549

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

399600

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.536

High

399618

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

399533

ADHX
Alcohol dehydrogenase class-3

1

0

High-throughput

0.518

High

399562

CBX1
Chromobox protein homolog 1

1

0

High-throughput

0.518

High

399613

ADTRP
Androgen-dependent TFPI-regulating protein

1

0

High-throughput

0.518

High

229199

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.513

High

399555

RBM5
RNA-binding protein 5

1

0

High-throughput

0.513

High

399586

HACD2
Very-long-chain

1

0

High-throughput

0.513

High

399616

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.513

High

399557

GEM
GTP-binding protein GEM

1

1

High-throughput

0.508

High

376576

EGF
Pro-epidermal growth factor

1

3

Small-scale

0.501

High

376660

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

6

Small-scale

0.501

High

399527

ITA2B
Integrin alpha-IIb

1

5

Small-scale

0.501

High

399528

ITA5
Integrin alpha-5

1

5

Small-scale

0.501

High

399530

SPRC
SPARC

1

3

Small-scale

0.501

High

399546

IBP5
Insulin-like growth factor-binding protein 5

1

2

Small-scale

0.501

High

399560

TGFB2
Transforming growth factor beta-2 proprotein

1

6

Small-scale

0.501

High

399599

RHXF1
Rhox homeobox family member 1

1

3

High-throughput

0.494

High

399652

ETV7
Transcription factor ETV7

1

1

High-throughput

0.494

High

399564

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.489

High

399581

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

399585

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.489

High

399609

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.489

High

399630

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

2

High-throughput

0.489

High

399636

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

399645

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

399646

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

359565

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.481

High

370389

KNG1
Kininogen-1

1

0

Small-scale

0.480

High

377046

COLI
Pro-opiomelanocortin

1

0

Small-scale

0.480

High

377809

IGF2
Insulin-like growth factor 2

1

0

Small-scale

0.480

High

399529

FGF2
Fibroblast growth factor 2

1

0

Small-scale

0.480

High

399536

HGF
Hepatocyte growth factor

1

0

Small-scale

0.480

High

399537

PVR
Poliovirus receptor

1

0

Small-scale

0.480

High

399538

VEGFA
Vascular endothelial growth factor A, long form

1

0

Small-scale

0.480

High

399539

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

399541

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

Small-scale

0.480

High

399593

C163A
Scavenger receptor cysteine-rich type 1 protein M130

1

0

Small-scale

0.480

High

399624

LACRT
Extracellular glycoprotein lacritin

1

0

Small-scale

0.480

High

192418

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.479

High

362560

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

376461

LDLR
Low-density lipoprotein receptor

1

3

High-throughput

0.479

High

399520

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.479

High

399522

ITB3
Integrin beta-3

1

4

Small-scale

0.479

High

399526

CATB
Cathepsin B

1

1

Small-scale

0.479

High

399551

BASI
Basigin

1

1

High-throughput

0.479

High

399563

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

399605

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

399629

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

399651

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.479

High

399597

LNX2
Ligand of Numb protein X 2

1

2

High-throughput

0.464

High

399569

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.460

High

285026

EED
Polycomb protein EED

1

0

High-throughput

0.458

High

319279

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

399552

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

399556

ACLY
ATP-citrate synthase

1

0

High-throughput

0.458

High

399575

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

399612

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

399632

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

High-throughput

0.458

High

399640

ATX10
Ataxin-10

1

0

High-throughput

0.458

High

399641

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

399554

AMPH
Amphiphysin

1

2

Small-scale

0.457

High

193665

TPSN
Tapasin

1

1

High-throughput

0.445

High

399532

CLUS
Clusterin

1

4

High-throughput

0.445

High

399543

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

399625

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

156824

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

259285

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

330556

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

399518

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

399519

GCR
Glucocorticoid receptor

1

3

High-throughput

0.437

High

399567

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

399594

CUL9
Cullin-9

1

4

High-throughput

0.437

High

399610

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

399635

ANLN
Anillin

1

1

High-throughput

0.437

High

399570

MTA1
Metastasis-associated protein MTA1

1

0

Small-scale

0.426

High

399579

ANO6
Anoctamin-6

1

0

High-throughput

0.426

High

399595

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

399617

THIOM
Thioredoxin, mitochondrial

1

1

High-throughput

0.417

High

399524

JUN
Transcription factor Jun

1

6

High-throughput

0.407

High

399587

ARMX2
Armadillo repeat-containing X-linked protein 2

1

1

High-throughput

0.407

High

399627

OSBL2
Oxysterol-binding protein-related protein 2

1

1

High-throughput

0.407

High

399650

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

1

High-throughput

0.407

High

228891

CF410
Cilia- and flagella-associated protein 410

3

0

High-throughput

0.352

High

168170

HAT1
Histone acetyltransferase type B catalytic subunit

3

0

High-throughput

0.345

High

294964

RPP40
Ribonuclease P protein subunit p40

3

0

High-throughput

0.345

High

399574

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

3

0

High-throughput

0.345

High

399582

MBOA5
Lysophospholipid acyltransferase 5

3

0

High-throughput

0.345

High

399603

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

3

0

High-throughput

0.345

High

399611

ISOC1
Isochorismatase domain-containing protein 1

3

0

High-throughput

0.345

High

342417

RPP29
Ribonuclease P protein subunit p29

2

0

High-throughput

0.328

High

399531

GLI4
Zinc finger protein GLI4

2

0

High-throughput

0.328

High

399558

NP1L1
Nucleosome assembly protein 1-like 1

2

0

High-throughput

0.328

High

399559

RRP1
Ribosomal RNA processing protein 1 homolog A

2

0

High-throughput

0.328

High

399566

OTUD4
OTU domain-containing protein 4

2

0

High-throughput

0.328

High

399590

FBX33
F-box only protein 33

2

0

High-throughput

0.328

High

399601

ZN483
Zinc finger protein 483

2

0

High-throughput

0.328

High

399631

ZN696
Zinc finger protein 696

2

0

High-throughput

0.328

High

399633

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

399649

DCAF1
DDB1- and CUL4-associated factor 1

2

0

High-throughput

0.328

High

399644

UBQL2
Ubiquilin-2

2

0

High-throughput

0.316

High

399544

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.282

High

399550

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

0

High-throughput

0.282

High

399561

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.282

High

399534

CDK4
Cyclin-dependent kinase 4

1

0

High-throughput

0.279

Low

399548

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

0

High-throughput

0.279

Low

399572

TTLL4
Tubulin monoglutamylase TTLL4

1

0

High-throughput

0.279

Low

399583

RHGBA
Rho GTPase-activating protein 11A

1

0

High-throughput

0.279

Low

399589

TRM11
tRNA

1

0

High-throughput

0.279

Low

399598

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

399602

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

399608

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.279

Low

399621

TR61B
tRNA

1

0

High-throughput

0.279

Low

399626

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.279

Low

399607

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.265

Low

399553

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.251

Low

399576

SIX1
Homeobox protein SIX1

1

0

High-throughput

0.251

Low

399565

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

399571

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.249

Low

399578

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

399604

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low

399619

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

291044

UTP20
Small subunit processome component 20 homolog

1

0

High-throughput

0.232

Low

399545

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

Small-scale

0.232

Low

399580

FAXC
Failed axon connections homolog

1

0

High-throughput

0.232

Low

399584

TBPL2
TATA box-binding protein-like 2

1

0

High-throughput

0.232

Low

399591

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.232

Low

399596

RBFA
Putative ribosome-binding factor A, mitochondrial

1

0

High-throughput

0.232

Low

399615

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

Small-scale

0.232

Low

399620

LRRC1
Leucine-rich repeat-containing protein 1

1

0

High-throughput

0.232

Low

399638

TM160
Transmembrane protein 160

1

0

High-throughput

0.232

Low

399648

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025