Protein: GEM
GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)

Gene: GEM
Organism: Homo sapiens
Interactions: 156
UniProt ID: P55040

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000287 - magnesium ion binding
GO:0003924 - GTPase activity
GO:0005246 - calcium channel regulator activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

933901

PDLI7
PDZ and LIM domain protein 7

4

3

High-throughput

0.799

High

933841

USH1G
pre-mRNA splicing regulator USH1G

2

6

High-throughput

0.783

High

933849

TBC3G
TBC1 domain family member 3G

2

9

High-throughput

0.783

High

933898

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

2

High-throughput

0.783

High

933912

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.783

High

933913

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

19

High-throughput

0.750

High

783210

TRI23
E3 ubiquitin-protein ligase TRIM23

5

20

High-throughput

0.720

High

933906

GMIP
GEM-interacting protein

1

4

Small-scale

0.713

High

933864

AN36B
Ankyrin repeat domain-containing protein 36B

2

5

High-throughput

0.700

High

933875

ASB15
Ankyrin repeat and SOCS box protein 15

2

3

High-throughput

0.700

High

933897

PKHF2
Pleckstrin homology domain-containing family F member 2

2

8

High-throughput

0.700

High

933844

MTUS2
Microtubule-associated tumor suppressor candidate 2

4

8

High-throughput

0.680

High

571908

TRI27
Zinc finger protein RFP

3

5

High-throughput

0.675

High

933830

GOGA2
Golgin subfamily A member 2

3

8

High-throughput

0.675

High

933884

LZTS2
Leucine zipper putative tumor suppressor 2

3

9

High-throughput

0.675

High

933894

GO45
Golgin-45

3

1

High-throughput

0.675

High

933915

IKZF3
Zinc finger protein Aiolos

3

1

High-throughput

0.675

High

656083

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

1

High-throughput

0.665

High

933827

Q05BL1
TP53BP2 protein

1

4

High-throughput

0.665

High

933843

RUN3A
RUN domain-containing protein 3A

1

4

High-throughput

0.662

High

933836

ASPP2
Apoptosis-stimulating of p53 protein 2

1

6

High-throughput

0.621

High

933814

KR107
Keratin-associated protein 10-7

3

4

High-throughput

0.616

High

933835

TRAF1
TNF receptor-associated factor 1

3

5

High-throughput

0.616

High

933839

K1H1
Keratin, type I cuticular Ha1

3

9

High-throughput

0.616

High

933857

KCTD9
BTB/POZ domain-containing protein KCTD9

3

5

High-throughput

0.616

High

928733

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

2

1

High-throughput

0.615

High

729700

1433B
14-3-3 protein beta/alpha

2

18

Small-scale

0.612

High

74332

ZBT42
Zinc finger and BTB domain-containing protein 42

2

3

High-throughput

0.606

High

193846

ZSC9
Zinc finger and SCAN domain-containing protein 9

2

2

High-throughput

0.606

High

217073

MS18B
Protein Mis18-beta

2

1

High-throughput

0.606

High

250228

VINEX
Vinexin

2

11

High-throughput

0.606

High

385253

K2C6A
Keratin, type II cytoskeletal 6A

2

5

High-throughput

0.606

High

474577

VIME
Vimentin

2

7

High-throughput

0.606

High

505700

ZN688
Zinc finger protein 688

2

2

High-throughput

0.606

High

581762

MYOG
Myogenin

2

1

High-throughput

0.606

High

600085

ZNF20
Zinc finger protein 20

2

1

High-throughput

0.606

High

870119

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

2

4

High-throughput

0.606

High

933829

TLE5
TLE family member 5

2

1

High-throughput

0.606

High

933831

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

933832

TRAF2
TNF receptor-associated factor 2

2

9

High-throughput

0.606

High

933833

TRI32
E3 ubiquitin-protein ligase TRIM32

2

8

High-throughput

0.606

High

933840

INSC
Protein inscuteable homolog

2

1

High-throughput

0.606

High

933850

ZN774
Zinc finger protein 774

2

1

High-throughput

0.606

High

933852

MORN3
MORN repeat-containing protein 3

2

1

High-throughput

0.606

High

933860

TRI69
E3 ubiquitin-protein ligase TRIM69

2

6

High-throughput

0.606

High

933866

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

933881

SPAG5
Sperm-associated antigen 5

2

5

High-throughput

0.606

High

933890

PRD14
PR domain zinc finger protein 14

2

1

High-throughput

0.606

High

933893

CARD9
Caspase recruitment domain-containing protein 9

2

2

High-throughput

0.606

High

933896

ZN552
Zinc finger protein 552

2

2

High-throughput

0.606

High

933899

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

2

High-throughput

0.606

High

933904

PIHD1
PIH1 domain-containing protein 1

2

1

High-throughput

0.606

High

933905

WWOX
WW domain-containing oxidoreductase

2

4

High-throughput

0.606

High

933917

PLAL2
Zinc finger protein PLAGL2

2

1

High-throughput

0.606

High

933825

CACB1
Voltage-dependent L-type calcium channel subunit beta-1

2

1

Small-scale

0.584

High

353679

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

933834

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

933838

MESD
LRP chaperone MESD

2

0

High-throughput

0.580

High

933853

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

933854

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.580

High

933870

DBF4B
Protein DBF4 homolog B

2

0

High-throughput

0.580

High

933873

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.580

High

933876

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

933878

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

933883

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

0

High-throughput

0.580

High

933888

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.580

High

933891

KTBL1
KATNB1-like protein 1

2

0

High-throughput

0.580

High

933900

ZC4H2
Zinc finger C4H2 domain-containing protein

2

0

High-throughput

0.580

High

933914

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.580

High

933820

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.575

High

933889

TRI54
Tripartite motif-containing protein 54

1

19

High-throughput

0.573

High

933918

ADIP
Afadin- and alpha-actinin-binding protein

1

1

High-throughput

0.573

High

64528

CC88B
Coiled-coil domain-containing protein 88B

2

6

High-throughput

0.553

High

65023

GG6L9
Golgin subfamily A member 6-like protein 9

2

12

High-throughput

0.553

High

70155

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

252756

AP180
Clathrin coat assembly protein AP180

2

1

High-throughput

0.553

High

300326

KRT34
Keratin, type I cuticular Ha4

2

8

High-throughput

0.553

High

300559

KRT36
Keratin, type I cuticular Ha6

2

6

High-throughput

0.553

High

933815

KR108
Keratin-associated protein 10-8

2

3

High-throughput

0.553

High

933822

KRT83
Keratin, type II cuticular Hb3

2

4

High-throughput

0.553

High

933845

EFHC2
EF-hand domain-containing family member C2

2

4

High-throughput

0.553

High

933863

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

2

High-throughput

0.553

High

933865

USBP1
Harmonin-binding protein USHBP1

2

2

High-throughput

0.553

High

933877

HOOK2
Protein Hook homolog 2

2

7

High-throughput

0.553

High

933887

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.553

High

933911

TRI10
Tripartite motif-containing protein 10

2

6

High-throughput

0.553

High

933919

COG6
Conserved oligomeric Golgi complex subunit 6

2

1

High-throughput

0.553

High

933916

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.553

High

587034

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

581463

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

669856

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.536

High

690854

1433T
14-3-3 protein theta

1

18

High-throughput

0.536

High

933817

1433G
14-3-3 protein gamma

1

18

High-throughput

0.536

High

933818

PRS8
26S proteasome regulatory subunit 8

1

2

High-throughput

0.536

High

933819

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

933821

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.536

High

933895

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.536

High

933828

DEUP1
Deuterosome assembly protein 1

1

7

High-throughput

0.523

High

933847

C102B
Coiled-coil domain-containing protein 102B

1

1

High-throughput

0.523

High

933848

K1C40
Keratin, type I cytoskeletal 40

1

8

High-throughput

0.523

High

933858

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.523

High

933868

PNMA1
Paraneoplastic antigen Ma1

1

2

High-throughput

0.523

High

933879

COG8
Conserved oligomeric Golgi complex subunit 8

1

1

High-throughput

0.523

High

933811

CLD15
Claudin-15

1

0

High-throughput

0.518

High

399557

VTNC
Vitronectin

1

1

High-throughput

0.508

High

459256

CATL1
Procathepsin L

1

1

High-throughput

0.508

High

933909

RBX2
RING-box protein 2

1

10

High-throughput

0.508

High

188225

HDAC3
Histone deacetylase 3

1

7

Small-scale

0.500

High

482866

TPM1
Tropomyosin alpha-1 chain

1

6

High-throughput

0.489

High

923690

SMTN
Smoothelin

1

5

High-throughput

0.489

High

641761

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.486

High

933812

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.486

High

933885

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.486

High

933855

CLC4G
C-type lectin domain family 4 member G

1

8

High-throughput

0.481

High

933882

MGLL
Monoglyceride lipase

1

1

High-throughput

0.481

High

933837

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.479

High

2833

A0A0C4DFN3
Monoglyceride lipase

1

1

High-throughput

0.470

High

369641

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.464

High

562708

BMP1
Bone morphogenetic protein 1

1

4

High-throughput

0.464

High

933823

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

933920

NCOR2
Nuclear receptor corepressor 2

1

0

Small-scale

0.458

High

933826

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.457

High

933921

NEMO
NF-kappa-B essential modulator

1

17

High-throughput

0.457

High

933856

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.445

High

933813

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

933816

YPEL3
Protein yippee-like 3

1

1

High-throughput

0.439

High

933851

KLC3
Kinesin light chain 3

1

3

High-throughput

0.439

High

343745

LDOC1
Protein LDOC1

1

0

High-throughput

0.438

High

459877

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.437

High

464134

TPM2
Tropomyosin beta chain

1

5

High-throughput

0.437

High

116309

H3BQF1
Adenine phosphoribosyltransferase

1

1

High-throughput

0.407

High

933846

Q5TCU3
Tropomyosin 2

1

6

High-throughput

0.407

High

933908

TFP11
Tuftelin-interacting protein 11

4

0

High-throughput

0.364

High

229990

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

0

High-throughput

0.352

High

933867

IN80E
INO80 complex subunit E

3

0

High-throughput

0.352

High

269163

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

605446

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

933824

CDR2
Cerebellar degeneration-related protein 2

2

0

High-throughput

0.316

High

933842

MSS51
Putative protein MSS51 homolog, mitochondrial

2

0

High-throughput

0.316

High

933859

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

2

0

High-throughput

0.316

High

933861

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.316

High

933862

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

933869

FSAF1
40S small subunit processome assembly factor 1

2

0

High-throughput

0.316

High

933871

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

933872

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.316

High

933874

POF1B
Protein POF1B

2

0

High-throughput

0.316

High

933880

TGM7
Protein-glutamine gamma-glutamyltransferase Z

2

0

High-throughput

0.316

High

933886

BEGIN
Brain-enriched guanylate kinase-associated protein

2

0

High-throughput

0.316

High

933902

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.316

High

933903

SPAT6
Spermatogenesis-associated protein 6

2

0

High-throughput

0.316

High

933907

LR2BP
LRP2-binding protein

2

0

High-throughput

0.316

High

933910

ZMAT5
Zinc finger matrin-type protein 5

2

0

High-throughput

0.316

High

903598

GALK1
Galactokinase

1

0

High-throughput

0.279

Low

933892

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

127471

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.265

Low

388840

APOH
Beta-2-glycoprotein 1

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025