HitPredict

Interactor 1: DEST (P60981)
Destrin (Actin-depolymerizing factor) (ADF)
Gene: DSTN

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 165 Hs			1 377
+	Hs
		618104 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		891649 DEST_HUMAN (1-165): 6.05e-74: 220: 100.00		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		894652 DEST_HUMAN (1-165): 6.05e-74: 220: 100.00		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		894665 DEST_HUMAN (1-165): 6.05e-74: 220: 100.00		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Mm
		578583 COF1_MOUSE (1-165): 2.57e-70: 211: 71.08		ACTB_MOUSE (4-377): 0: 598: 94.12
+	Hs
		1092828 Q549N0_HUMAN (1-165): 4.17e-70: 210: 68.68		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Hs
		618038 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		618049 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		618052 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		618053 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTS_HUMAN (1-377): 0: 598: 97.88
+	Hs
		618096 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		Q1KLZ0_HUMAN (4-377): 0: 598: 94.12
+	Rn
		799735 COF1_RAT (1-165): 4.8e-70: 210: 71.08		ACTB_RAT (4-377): 0: 598: 94.12
+	Hs
		891817 Q549N0_HUMAN (1-165): 4.17e-70: 210: 68.68		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		892124 COF2_HUMAN (1-165): 4.17e-70: 210: 68.68		ACTB_HUMAN (4-377): 0: 598: 94.12
+	Hs
		929891 Q549N0_HUMAN (1-165): 4.17e-70: 210: 68.68		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		930059 COF2_HUMAN (1-165): 4.17e-70: 210: 68.68		ACTG_HUMAN (4-377): 0: 598: 94.39
+	Hs
		932464 COF2_HUMAN (1-165): 4.17e-70: 210: 68.68		ACTC_HUMAN (1-377): 0: 598: 98.41
+	Hs
		618046 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTA_HUMAN (1-377): 0: 596: 100.00
+	Hs
		618050 COF1_HUMAN (1-165): 5.13e-70: 210: 71.08		ACTH_HUMAN (4-377): 0: 591: 99.20
+	At
		477715 ADF4_ARATH (2-152): 4.15e-51: 161: 32.90		ACT1_ARATH (1-377): 0: 591: 87.80