Protein: S12A2
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (BSC2) (Na-K-2Cl cotransporter 1) (hNKCC1)

Gene: S12A2, SLC12A2
Organism: Homo sapiens
Interactions: 229
UniProt ID: P55011

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006883 - intracellular sodium ion homeostasis
GO:0006884 - cell volume homeostasis
GO:0006972 - hyperosmotic response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

609634

LEG3
Galectin-3

5

20

Small-scale

0.712

High

375323

RASK
GTPase KRas

4

20

High-throughput

0.676

High

127306

LEG8
Galectin-8

3

20

High-throughput

0.667

High

698523

CALX
Calnexin

3

9

High-throughput

0.657

High

125354

LEG9
Galectin-9

5

20

High-throughput

0.650

High

373857

RASN
GTPase NRas

3

20

High-throughput

0.640

High

374501

RASH
GTPase HRas

3

19

High-throughput

0.640

High

582726

EZRI
Ezrin

3

2

Small-scale

0.640

High

845503

PI2R
Prostacyclin receptor

2

5

High-throughput

0.628

High

855312

5HT3A
5-hydroxytryptamine receptor 3A

2

6

High-throughput

0.628

High

933446

RN149
E3 ubiquitin-protein ligase RNF149

2

4

High-throughput

0.611

High

933422

LEG9C
Galectin-9C

3

20

High-throughput

0.609

High

933386

DLK1
Protein delta homolog 1

2

5

High-throughput

0.601

High

933388

EFNB1
Ephrin-B1

2

1

High-throughput

0.601

High

170718

CLGN
Calmegin

3

9

High-throughput

0.587

High

218010

TGON2
Trans-Golgi network integral membrane protein 2

2

4

High-throughput

0.584

High

540379

LAMP1
Lysosome-associated membrane glycoprotein 1

2

6

High-throughput

0.584

High

933380

ARF6
ADP-ribosylation factor 6

2

7

High-throughput

0.584

High

933382

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

933495

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

9

Small-scale

0.576

High

933409

DHC24
Delta(24)-sterol reductase

2

0

High-throughput

0.576

High

933370

S12A2
Solute carrier family 12 member 2

1

13

Small-scale

0.575

High

299123

FLOT1
Flotillin-1

2

4

High-throughput

0.571

High

395758

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

903851

BAP31
B-cell receptor-associated protein 31

2

4

High-throughput

0.571

High

933430

RHOU
Rho-related GTP-binding protein RhoU

2

20

High-throughput

0.571

High

933373

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

64944

ARRD5
Arrestin domain-containing protein 5

1

2

High-throughput

0.536

High

165920

FFAR1
Free fatty acid receptor 1

1

11

High-throughput

0.536

High

248467

O10H2
Olfactory receptor 10H2

1

11

High-throughput

0.536

High

549754

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

2

High-throughput

0.536

High

771107

APJ
Apelin receptor

1

6

High-throughput

0.536

High

888835

TMEDA
Transmembrane emp24 domain-containing protein 10

1

6

High-throughput

0.536

High

933397

ILK
Scaffold protein ILK

1

1

High-throughput

0.536

High

933400

KCNC3
Voltage-gated potassium channel KCNC3

1

1

High-throughput

0.536

High

933418

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.536

High

933439

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

4

High-throughput

0.536

High

933444

SIDT2
SID1 transmembrane family member 2

1

2

High-throughput

0.536

High

933447

ARRD4
Arrestin domain-containing protein 4

1

2

High-throughput

0.536

High

933448

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

4

High-throughput

0.536

High

933461

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

933475

TTYH1
Protein tweety homolog 1

1

4

High-throughput

0.536

High

933482

GPR35
G-protein coupled receptor 35

1

7

High-throughput

0.536

High

933505

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

365751

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

719300

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.513

High

933415

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

933433

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

0

High-throughput

0.513

High

933459

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

700779

DMB
HLA class II histocompatibility antigen, DM beta chain

1

2

High-throughput

0.489

High

933402

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

4

High-throughput

0.489

High

933414

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

933452

TMED6
Transmembrane emp24 domain-containing protein 6

1

9

High-throughput

0.489

High

933462

ZDH12
Palmitoyltransferase ZDHHC12

1

4

High-throughput

0.489

High

126524

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

173892

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.479

High

179859

BET1
BET1 homolog

1

5

High-throughput

0.479

High

181696

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.479

High

189480

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

225976

STX6
Syntaxin-6

1

5

High-throughput

0.479

High

241204

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

327210

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.479

High

341009

DIRA3
GTP-binding protein Di-Ras3

1

11

High-throughput

0.479

High

343573

OXSR1
Serine/threonine-protein kinase OSR1

1

10

Small-scale

0.479

High

363034

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

411652

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

417343

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

418039

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

440008

LCK
Tyrosine-protein kinase Lck

1

6

High-throughput

0.479

High

463420

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

466173

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

529423

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.479

High

548324

CP2C9
Cytochrome P450 2C9

1

1

High-throughput

0.479

High

555977

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

561970

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

580956

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601223

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603907

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

605611

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

High-throughput

0.479

High

630483

RAB3B
Ras-related protein Rab-3B

1

10

High-throughput

0.479

High

630740

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.479

High

631140

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

633899

ATP4A
Potassium-transporting ATPase alpha chain 1

1

3

Small-scale

0.479

High

710144

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.479

High

715502

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

767410

RADI
Radixin

1

1

High-throughput

0.479

High

845570

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

880497

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

894650

EMD
Emerin

1

2

High-throughput

0.479

High

900744

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901148

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

901750

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

909991

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

932048

EPHA4
Ephrin type-A receptor 4

1

7

High-throughput

0.479

High

933371

AFAD
Afadin

1

3

High-throughput

0.479

High

933372

ARL4C
ADP-ribosylation factor-like protein 4C

1

15

High-throughput

0.479

High

933374

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

933375

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

933376

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

933377

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.479

High

933378

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

933379

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

933381

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.479

High

933383

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

933384

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

933387

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

933390

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

933393

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

933396

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

933406

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

933408

EPHA7
Ephrin type-A receptor 7

1

6

High-throughput

0.479

High

933410

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

933411

EREP1
Endosomal transmembrane epsin interactor 1

1

4

High-throughput

0.479

High

933413

OCLN
Occludin

1

1

High-throughput

0.479

High

933416

ZACN
Ligand-gated cation channel ZACN

1

6

High-throughput

0.479

High

933421

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

933423

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

933427

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

933436

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

933437

ARL14
ADP-ribosylation factor-like protein 14

1

8

High-throughput

0.479

High

933442

CGAS
Cyclic GMP-AMP synthase

1

4

Small-scale

0.479

High

933449

MCLN3
Mucolipin-3

1

1

High-throughput

0.479

High

933450

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.479

High

933454

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

933457

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

933458

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

933463

DNJC1
DnaJ homolog subfamily C member 1

1

19

High-throughput

0.479

High

933464

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

933466

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

933467

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

933469

DERL1
Derlin-1

1

1

High-throughput

0.479

High

933471

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

933477

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.479

High

933478

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

933481

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

933485

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

933490

ELOV5
Very long chain fatty acid elongase 5

1

11

High-throughput

0.479

High

933492

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

933496

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.479

High

933497

SEC63
Translocation protein SEC63 homolog

1

11

High-throughput

0.479

High

933500

LAMP3
Lysosome-associated membrane glycoprotein 3

1

6

High-throughput

0.479

High

212939

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.458

High

611051

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

820613

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

847484

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

933392

1433F
14-3-3 protein eta

1

0

High-throughput

0.458

High

933398

CUL3
Cullin-3

1

0

High-throughput

0.458

High

933460

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

933465

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

933472

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

933479

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

933480

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

933486

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

933493

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

933494

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

222260

PSCA
Prostate stem cell antigen

1

1

High-throughput

0.445

High

248855

GSDME
Gasdermin-E

1

1

High-throughput

0.445

High

440465

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.445

High

484089

PGFRB
Platelet-derived growth factor receptor beta

1

4

High-throughput

0.445

High

541412

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.445

High

607915

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

5

High-throughput

0.445

High

641930

CD9
CD9 antigen

1

3

High-throughput

0.445

High

658668

JAK1
Tyrosine-protein kinase JAK1

1

11

High-throughput

0.445

High

898965

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

907988

VAMP7
Vesicle-associated membrane protein 7

1

3

High-throughput

0.445

High

914390

EFNB2
Ephrin-B2

1

1

High-throughput

0.445

High

931325

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.445

High

933391

NOTC2
Neurogenic locus notch homolog protein 2

1

1

High-throughput

0.445

High

933395

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.445

High

933401

FLOT2
Flotillin-2

1

4

High-throughput

0.445

High

933403

SL9A5
Sodium/hydrogen exchanger 5

1

3

High-throughput

0.445

High

933435

AGRG5
Adhesion G-protein coupled receptor G5

1

5

High-throughput

0.445

High

933441

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.445

High

933453

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.445

High

933456

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

4

High-throughput

0.445

High

933476

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.445

High

933488

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.445

High

933499

NOTC3
Neurogenic locus notch homolog protein 3

1

1

High-throughput

0.445

High

933501

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

933503

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

4

High-throughput

0.445

High

933504

HECD4
Probable E3 ubiquitin-protein ligase HECTD4

1

4

High-throughput

0.445

High

105643

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

827154

ARL1
ADP-ribosylation factor-like protein 1

1

8

High-throughput

0.437

High

933389

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.437

High

933407

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.437

High

933412

MK14
Mitogen-activated protein kinase 14

1

1

Small-scale

0.437

High

933428

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

933431

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

933445

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

933455

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

933473

DJC25
DnaJ homolog subfamily C member 25

1

11

High-throughput

0.437

High

933474

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

933483

E41LA
Band 4.1-like protein 4A

1

1

High-throughput

0.437

High

933487

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

933502

DJC16
DnaJ homolog subfamily C member 16

1

16

High-throughput

0.437

High

562789

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.426

High

577677

PLAK
Junction plakoglobin

1

0

High-throughput

0.426

High

800469

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.426

High

933419

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.426

High

933420

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

933438

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.426

High

933443

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.426

High

933470

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.426

High

933484

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.426

High

933491

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.426

High

933405

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.407

High

933394

SRSF1
Serine/arginine-rich splicing factor 1

1

0

High-throughput

0.279

Low

933434

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

933489

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

933440

COMD1
COMM domain-containing protein 1

1

0

Small-scale

0.275

Low

655126

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.269

Low

139836

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

272012

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

317619

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.249

Low

353148

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

519082

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

933385

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

933399

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

933404

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

933417

MIDN
Midnolin

1

0

High-throughput

0.249

Low

933424

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

933429

MOB2
MOB kinase activator 2

1

0

High-throughput

0.249

Low

933432

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

933451

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low

933425

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

933426

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.232

Low

933468

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.232

Low

933498

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025