HitPredict

Interactor 1: UBC12 (P61081)
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.34) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)
Gene: UBE2M

Interactor 2: KLH42 (Q9P2K6)
Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)
Gene: KLHL42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 28581483, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 505
+	Hs
		896118 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21
+	Hs
		849471 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56
+	Hs
		896269 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH20_HUMAN (4-499): 2.21e-108: 336: 18.99
+	Hs
		849470 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLHL9_HUMAN (2-504): 4.12e-102: 320: 17.34
+	Hs
		849329 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75
+	Hs
		895941 UB2D3_HUMAN (30-173): 1.29e-73: 219: 31.51		KLHL3_HUMAN (3-497): 1.88e-99: 312: 17.01
+	Hs
		896243 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH13_HUMAN (2-505): 5.44e-102: 321: 18.56
+	Hs
		896241 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLHL9_HUMAN (2-504): 4.12e-102: 320: 17.34
+	Hs
		1282358 UB2E3_HUMAN (5-173): 2.2e-72: 218: 26.90		KLH42_HUMAN (1-505): 3.3e-98: 307: 100.00
+	Hs
		828997 UBE2A_HUMAN (26-172): 2.67e-69: 208: 28.19		KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75
+	Hs
		299511 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH18_HUMAN (2-498): 3.63e-100: 314: 17.40
+	Hs
		896119 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH26_HUMAN (4-504): 1.01e-88: 285: 19.30
+	Hs
		896130 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH24_HUMAN (3-503): 6.17e-88: 283: 16.70
+	Hs
		896117 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		KLH12_HUMAN (56-450): 1.45e-54: 194: 13.03
+	Hs
		307160 UB2D1_HUMAN (30-173): 2.47e-75: 224: 30.14		KLHL2_HUMAN (172-346): 7.92e-23: 103: 23.89
+	Hs
		896288 UBC12_HUMAN (1-183): 5.92e-69: 209: 100.00		NS1BP_HUMAN (264-398): 3.98e-10: 64.3: 27.47
+	Hs
		135913 UBE2C_HUMAN (10-155): 3e-22: 90.1: 34.46		KLHL2_HUMAN (172-346): 7.92e-23: 103: 23.89
+	Hs
		307184 Q5TZN3_HUMAN (10-155): 3e-22: 90.1: 34.46		KLHL2_HUMAN (172-346): 7.92e-23: 103: 23.89