Protein: RPAP3
RNA polymerase II-associated protein 3

Gene: RPAP3
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q9H6T3

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005929 - cilium
GO:0036064 - ciliary basal body
GO:0050821 - protein stabilization
GO:0097255 - R2TP complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1435197

RUVB1
RuvB-like 1

12

10

Small-scale

0.981

High

1435196

RUVB2
RuvB-like 2

10

10

Small-scale

0.975

High

967972

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

7

7

High-throughput

0.969

High

786853

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

8

7

High-throughput

0.966

High

461939

HS90A
Heat shock protein HSP 90-alpha

5

20

Small-scale

0.936

High

468809

HS90B
Heat shock protein HSP 90-beta

3

20

Small-scale

0.853

High

1435183

PIHD1
PIH1 domain-containing protein 1

14

3

Small-scale

0.761

High

1435166

RPAP3
RNA polymerase II-associated protein 3

2

16

High-throughput

0.754

High

621967

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

9

1

Small-scale

0.752

High

316439

RMP
Unconventional prefoldin RPB5 interactor 1

9

4

Small-scale

0.751

High

1435189

UXT
Protein UXT

7

1

Small-scale

0.748

High

1398610

DAA10
Dynein axonemal assembly factor 10

7

3

Small-scale

0.747

High

182184

PFD6
Prefoldin subunit 6

6

1

Small-scale

0.730

High

1435192

PFD2
Prefoldin subunit 2

8

0

Small-scale

0.715

High

165092

RPC1
DNA-directed RNA polymerase III subunit RPC1

5

6

High-throughput

0.709

High

1435178

PDRG1
p53 and DNA damage-regulated protein 1

6

0

Small-scale

0.699

High

180399

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

4

5

High-throughput

0.694

High

731618

STIP1
Stress-induced-phosphoprotein 1

1

16

High-throughput

0.691

High

968447

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.691

High

1125666

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.691

High

1435200

SGT1
Protein SGT1 homolog

1

19

High-throughput

0.691

High

1435182

RPC2
DNA-directed RNA polymerase III subunit RPC2

3

7

High-throughput

0.667

High

1435199

RPC10
DNA-directed RNA polymerase III subunit RPC10

3

3

High-throughput

0.650

High

912233

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

5

2

High-throughput

0.650

High

1435180

RPC5
DNA-directed RNA polymerase III subunit RPC5

3

0

High-throughput

0.638

High

340035

RPA1
DNA-directed RNA polymerase I subunit RPA1

4

6

High-throughput

0.633

High

1434855

ASB7
Ankyrin repeat and SOCS box protein 7

2

14

High-throughput

0.628

High

1313047

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.628

High

723090

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

7

High-throughput

0.626

High

1435206

NEMO
NF-kappa-B essential modulator

2

7

Small-scale

0.624

High

165745

PPE2
Serine/threonine-protein phosphatase with EF-hands 2

1

18

High-throughput

0.618

High

600938

HSP76
Heat shock 70 kDa protein 6

1

20

High-throughput

0.618

High

761882

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.618

High

953999

IF4A1
Eukaryotic initiation factor 4A-I

1

7

High-throughput

0.618

High

1106073

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.618

High

1289633

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.618

High

247432

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

2

11

High-throughput

0.611

High

331801

MTMR5
Myotubularin-related protein 5

2

8

High-throughput

0.611

High

430646

RPC4
DNA-directed RNA polymerase III subunit RPC4

2

1

High-throughput

0.611

High

861782

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

15

High-throughput

0.602

High

1435203

TELO2
Telomere length regulation protein TEL2 homolog

2

3

Small-scale

0.601

High

1435175

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

3

3

High-throughput

0.593

High

912125

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.585

High

923538

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

959056

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

983704

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.585

High

667453

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

6

High-throughput

0.585

High

132301

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

14

Small-scale

0.584

High

621747

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

5

High-throughput

0.584

High

1138640

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

7

High-throughput

0.584

High

839085

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

High-throughput

0.575

High

1435191

ZNHI2
Zinc finger HIT domain-containing protein 2

2

1

High-throughput

0.567

High

316017

RECQ4
ATP-dependent DNA helicase Q4

1

16

High-throughput

0.553

High

515805

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

2

High-throughput

0.553

High

1245575

Q6PK50
HSP90AB1 protein

1

20

High-throughput

0.553

High

1435193

GPN3
GPN-loop GTPase 3

2

1

High-throughput

0.549

High

1435172

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.546

High

415865

HSPB1
Heat shock protein beta-1

1

8

High-throughput

0.541

High

1209663

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

Small-scale

0.536

High

208083

TTI1
TELO2-interacting protein 1 homolog

1

1

Small-scale

0.536

High

209674

SERA
D-3-phosphoglycerate dehydrogenase

1

4

High-throughput

0.536

High

216817

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.536

High

322998

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

6

High-throughput

0.536

High

650579

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

7

High-throughput

0.536

High

866477

PA24A
Cytosolic phospholipase A2

1

4

High-throughput

0.536

High

905681

IRAK1
Interleukin-1 receptor-associated kinase 1

1

4

High-throughput

0.536

High

954611

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.536

High

1114309

CUL3
Cullin-3

1

10

High-throughput

0.536

High

1144163

TEBP
Prostaglandin E synthase 3

1

9

High-throughput

0.536

High

1154444

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

1158546

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.536

High

1243049

PKN3
Serine/threonine-protein kinase N3

1

6

High-throughput

0.536

High

1250425

KSR2
Kinase suppressor of Ras 2

1

9

High-throughput

0.536

High

1435169

CYBP
Calcyclin-binding protein

1

4

High-throughput

0.536

High

1435173

PAR6A
Partitioning defective 6 homolog alpha

1

5

High-throughput

0.536

High

1435198

NOP58
Nucleolar protein 58

1

7

High-throughput

0.536

High

246951

KDM1A
Lysine-specific histone demethylase 1A

2

5

High-throughput

0.533

High

1241797

PRP8
Pre-mRNA-processing-splicing factor 8

2

3

High-throughput

0.533

High

928551

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.523

High

976150

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

1

High-throughput

0.521

High

831435

CCNF
Cyclin-F

1

8

High-throughput

0.515

High

1239422

TTI2
TELO2-interacting protein 2

1

0

Small-scale

0.513

High

1294836

STX12
Syntaxin-12

1

0

High-throughput

0.513

High

516869

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

2

High-throughput

0.504

High

423178

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1394615

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

15

High-throughput

0.501

High

920505

DAPK1
Death-associated protein kinase 1

1

19

High-throughput

0.489

High

1435202

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

14

High-throughput

0.489

High

846790

GRK6
G protein-coupled receptor kinase 6

1

12

High-throughput

0.489

High

1148876

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

6

High-throughput

0.489

High

1270332

SPT6H
Transcription elongation factor SPT6

1

5

High-throughput

0.489

High

1292770

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1361088

MYO3B
Myosin-IIIb

1

5

High-throughput

0.489

High

1397655

IMP1L
Mitochondrial inner membrane protease subunit 1

1

4

High-throughput

0.489

High

1401002

PSKH2
Serine/threonine-protein kinase H2

1

13

High-throughput

0.489

High

1403429

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.489

High

157856

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

173366

XPO1
Exportin-1

1

16

High-throughput

0.479

High

184320

NPHP1
Nephrocystin-1

1

1

High-throughput

0.479

High

191095

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

7

High-throughput

0.479

High

273367

NPHP4
Nephrocystin-4

1

2

High-throughput

0.479

High

290153

OFD1
Centriole and centriolar satellite protein OFD1

1

3

High-throughput

0.479

High

326039

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

Small-scale

0.479

High

346333

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

558406

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

683515

IKBA
NF-kappa-B inhibitor alpha

1

15

Small-scale

0.479

High

714431

PML
Protein PML

1

10

High-throughput

0.479

High

862462

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

876171

TCPE
T-complex protein 1 subunit epsilon

1

13

High-throughput

0.479

High

939973

TPTE
Putative tyrosine-protein phosphatase TPTE

1

9

High-throughput

0.479

High

958512

ACTZ
Alpha-centractin

1

11

High-throughput

0.479

High

1067719

EP300
Histone acetyltransferase p300

1

18

High-throughput

0.479

High

1110082

HDAC1
Histone deacetylase 1

1

9

High-throughput

0.479

High

1149373

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1281612

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1286379

NEK8
Serine/threonine-protein kinase Nek8

1

13

High-throughput

0.479

High

1334175

POC1A
POC1 centriolar protein homolog A

1

19

High-throughput

0.479

High

1350451

BICD2
Protein bicaudal D homolog 2

1

8

High-throughput

0.479

High

1363850

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1364992

TSC1
Hamartin

1

11

High-throughput

0.479

High

1391766

AURKB
Aurora kinase B

1

11

High-throughput

0.479

High

1407241

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

5

High-throughput

0.479

High

1428972

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1430896

APC1
Anaphase-promoting complex subunit 1

1

1

High-throughput

0.479

High

1435167

EGLN3
Prolyl hydroxylase EGLN3

1

7

High-throughput

0.479

High

1435168

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

7

High-throughput

0.479

High

1435170

PIDD1
p53-induced death domain-containing protein 1

1

7

Small-scale

0.479

High

1435171

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.479

High

1435174

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1435185

MKS1
Tectonic-like complex member MKS1

1

1

High-throughput

0.479

High

1435186

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1435190

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1435194

ANC2
Anaphase-promoting complex subunit 2

1

14

High-throughput

0.479

High

1435195

FBW1B
F-box/WD repeat-containing protein 11

1

15

High-throughput

0.479

High

1435205

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.479

High

192855

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

245363

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

287476

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

1218068

CBPC6
Cytosolic carboxypeptidase 6

1

0

Small-scale

0.458

High

1404669

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

1435176

ANLN
Anillin

1

0

High-throughput

0.458

High

1349767

FBX25
F-box only protein 25

1

3

Small-scale

0.457

High

351169

ECD
Protein ecdysoneless homolog

1

2

Small-scale

0.445

High

933540

S12A3
Solute carrier family 12 member 3

1

12

High-throughput

0.445

High

944071

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.445

High

168900

PLD2
Phospholipase D2

1

5

High-throughput

0.437

High

373154

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

412617

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.437

High

551633

NFH
Neurofilament heavy polypeptide

1

8

High-throughput

0.437

High

589694

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

643073

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

696513

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

769185

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

787788

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

3

High-throughput

0.437

High

799475

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.437

High

829153

RFC5
Replication factor C subunit 5

1

1

High-throughput

0.437

High

880694

LMAN1
Protein ERGIC-53

1

4

High-throughput

0.437

High

1178965

SPKAP
A-kinase anchor protein SPHKAP

1

1

High-throughput

0.437

High

1217613

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

11

High-throughput

0.437

High

1218314

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

8

High-throughput

0.437

High

1236185

Q6N074
Chromatin-remodeling ATPase INO80

1

12

High-throughput

0.437

High

1255553

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.437

High

1276792

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1327199

FBXL6
F-box/LRR-repeat protein 6

1

13

High-throughput

0.437

High

1370664

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

14

High-throughput

0.437

High

1384437

PF21A
PHD finger protein 21A

1

9

High-throughput

0.437

High

1399351

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.437

High

1420794

TNG6
Transport and Golgi organization protein 6 homolog

1

1

High-throughput

0.437

High

1428626

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.437

High

1433437

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.437

High

1435177

HELLS
Lymphoid-specific helicase

1

12

High-throughput

0.437

High

1435179

DJC11
DnaJ homolog subfamily C member 11

1

20

High-throughput

0.437

High

1435181

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

1435184

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.437

High

1435187

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

3

High-throughput

0.437

High

1435201

LC7L2
Putative RNA-binding protein Luc7-like 2

1

2

High-throughput

0.437

High

1435204

SAM50
Sorting and assembly machinery component 50 homolog

1

3

High-throughput

0.437

High

516804

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

1381587

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

18

High-throughput

0.407

High

1162554

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

1364113

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

1415274

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.279

Low

1415493

DPCD
Protein DPCD

1

0

High-throughput

0.279

Low

1163666

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

High-throughput

0.249

Low

1232018

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1323843

INT1
Integrator complex subunit 1

1

0

High-throughput

0.249

Low

1435188

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025