HitPredict

Interactor 1: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0032991 - protein-containing complex GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 152 Hs			1 1620
+	Hs
		666567 UB2D3_HUMAN (4-149): 1.46e-78: 230: 45.89		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Hs
		666568 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		LTK_HUMAN (606-1458): 6.35e-175: 550: 53.24
+	Zm
		41149 A0A1D6NG29_MAIZE (2-148): 7.04e-78: 229: 69.94		B4G007_MAIZE (861-1385): 7.14e-153: 482: 17.55
+	Hs
		609235 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		445838 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		ROS1_HUMAN (1039-1461): 3.68e-112: 397: 37.75
+	Hs
		896419 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30
+	Hs
		609211 UBE2A_HUMAN (1-146): 5.35e-70: 209: 39.46		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		435592 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		896454 UBE2N_HUMAN (1-152): 1.51e-73: 218: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03