Protein: ENAH
Protein enabled homolog

Gene: ENAH
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q8N8S7

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005522 - profilin binding
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1156152

ZYX
Zyxin

7

20

Small-scale

0.965

High

896581

VASP
Vasodilator-stimulated phosphoprotein

7

16

Small-scale

0.960

High

1331376

TES
Testin

3

12

Small-scale

0.868

High

1331378

EVL
Ena/VASP-like protein

3

15

Small-scale

0.866

High

1331343

FBLI1
Filamin-binding LIM protein 1

1

17

High-throughput

0.691

High

1331347

AJUBA
LIM domain-containing protein ajuba

1

20

High-throughput

0.691

High

1316675

ABI1
Abl interactor 1

3

20

Small-scale

0.679

High

1331350

NECT4
Nectin-4

3

14

High-throughput

0.667

High

1331386

TACC3
Transforming acidic coiled-coil-containing protein 3

3

9

High-throughput

0.662

High

862303

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.646

High

441440

CHLE
Cholinesterase

2

2

High-throughput

0.628

High

762467

PROF2
Profilin-2

2

10

High-throughput

0.628

High

1331369

TMOD3
Tropomodulin-3

2

2

High-throughput

0.628

High

1115816

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

13

High-throughput

0.611

High

1331349

ANM6
Protein arginine N-methyltransferase 6

3

3

High-throughput

0.609

High

1331360

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

3

1

High-throughput

0.609

High

127138

APBB1
Amyloid beta precursor protein binding family B member 1

2

4

Small-scale

0.608

High

1331351

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

15

High-throughput

0.601

High

459677

PROF1
Profilin-1

2

10

Small-scale

0.595

High

952959

ACTB
Actin, cytoplasmic 1

2

19

High-throughput

0.584

High

537525

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.571

High

1331368

ABI2
Abl interactor 2

1

20

Small-scale

0.561

High

1331373

ABI3
ABI gene family member 3

1

20

Small-scale

0.561

High

988529

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.536

High

274664

DNJB6
DnaJ homolog subfamily B member 6

1

5

High-throughput

0.536

High

347175

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

530085

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.536

High

939944

TPTE
Putative tyrosine-protein phosphatase TPTE

1

3

High-throughput

0.536

High

964674

DCAF7
DDB1- and CUL4-associated factor 7

1

8

High-throughput

0.536

High

1331341

BBS1
BBSome complex member BBS1

1

1

High-throughput

0.536

High

1331364

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.536

High

1331381

DLGP4
Disks large-associated protein 4

1

7

High-throughput

0.536

High

1331379

BAIP2
BAR/IMD domain-containing adapter protein 2

1

20

Small-scale

0.527

High

995699

ACTC
Actin, alpha cardiac muscle 1

1

17

High-throughput

0.515

High

1055942

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.501

High

1127578

FAT1
Protocadherin Fat 1

1

8

Small-scale

0.501

High

1251251

DNMBP
Dynamin-binding protein

1

20

Small-scale

0.501

High

209302

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

10

High-throughput

0.489

High

1111112

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.489

High

1325207

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

2

High-throughput

0.489

High

1331346

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

1331354

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.489

High

1331357

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.489

High

1331372

NHSL3
NHS-like protein 3

1

13

High-throughput

0.489

High

1331384

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

13

High-throughput

0.489

High

1331385

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.489

High

703646

MK01
Mitogen-activated protein kinase 1

1

4

High-throughput

0.481

High

1331356

KLDC3
Kelch domain-containing protein 3

1

5

High-throughput

0.481

High

173078

XPO1
Exportin-1

1

12

High-throughput

0.479

High

242291

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

271546

ATG13
Autophagy-related protein 13

1

2

High-throughput

0.479

High

341991

CEP43
Centrosomal protein 43

1

3

High-throughput

0.479

High

412261

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

414219

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

582882

EZRI
Ezrin

1

15

High-throughput

0.479

High

613396

VINC
Vinculin

1

6

High-throughput

0.479

High

791539

SYUA
Alpha-synuclein

1

4

High-throughput

0.479

High

867278

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

927062

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

970784

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

993246

ACTG
Actin, cytoplasmic 2

1

19

High-throughput

0.479

High

1067512

EP300
Histone acetyltransferase p300

1

10

High-throughput

0.479

High

1107022

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1148362

KS6A1
Ribosomal protein S6 kinase alpha-1

1

14

Small-scale

0.479

High

1209392

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.479

High

1254654

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1258033

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

13

Small-scale

0.479

High

1289456

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1324013

RHG24
Rho GTPase-activating protein 24

1

11

High-throughput

0.479

High

1331342

BICD2
Protein bicaudal D homolog 2

1

18

High-throughput

0.479

High

1331344

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1331345

ATOH1
Transcription factor ATOH1

1

3

Small-scale

0.479

High

1331352

FMNL2
Formin-like protein 2

1

9

High-throughput

0.479

High

1331353

XPO6
Exportin-6

1

1

Small-scale

0.479

High

1331359

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1331362

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

Small-scale

0.479

High

1331363

MYO10
Unconventional myosin-X

1

7

Small-scale

0.479

High

1331365

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

4

Small-scale

0.479

High

1331371

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.479

High

1331375

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1331377

TBK1
Serine/threonine-protein kinase TBK1

1

6

High-throughput

0.479

High

1331380

NCKP1
Nck-associated protein 1

1

5

High-throughput

0.479

High

1331382

FND3A
Fibronectin type-III domain-containing protein 3A

1

14

High-throughput

0.479

High

481335

HMGB1
High mobility group protein B1

1

9

High-throughput

0.464

High

1331358

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1331361

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

1331370

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

386476

SPTA1
Spectrin alpha chain, erythrocytic 1

1

20

Small-scale

0.457

High

133540

ACATN
Acetyl-coenzyme A transporter 1

1

1

High-throughput

0.445

High

1331355

KIF2C
Kinesin-like protein KIF2C

1

15

High-throughput

0.445

High

1257656

XIRP1
Xin actin-binding repeat-containing protein 1

1

3

Small-scale

0.439

High

324984

HEXI1
Protein HEXIM1

1

3

High-throughput

0.437

High

589169

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

768653

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1041678

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

1

Small-scale

0.437

High

1063812

LG3BP
Galectin-3-binding protein

1

7

High-throughput

0.437

High

1251928

LMTK1
Serine/threonine-protein kinase LMTK1

1

19

High-throughput

0.437

High

1276489

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.437

High

1331340

PDZD8
PDZ domain-containing protein 8

1

3

High-throughput

0.437

High

1331366

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

1331374

HECW2
E3 ubiquitin-protein ligase HECW2

1

20

High-throughput

0.437

High

1331383

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.437

High

1331348

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

1259241

NCKX5
Sodium/potassium/calcium exchanger 5

1

1

High-throughput

0.407

High

1331367

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.299

High

1325640

SVOPL
Putative transporter SVOPL

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025