HitPredict

Interactor 1: ARP2 (P61161)
Actin-related protein 2 (Actin-like protein 2)
Gene: Actr2

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	25926623, 20876399
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0098794 - postsynapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 394 Mm			1 2527
+	Hs
		896912 ARP2_HUMAN (1-394): 0: 815: 100.00		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Mm
		892172 ACTB_MOUSE (1-388): 0: 574: 46.65		LRRK2_MOUSE (1-2527): 0: 2800: 100.00
+	Mm
		929787 ACTG_MOUSE (3-388): 0: 573: 46.37		LRRK2_MOUSE (1-2527): 0: 2800: 100.00
+	Hs
		891823 ACTB_HUMAN (1-388): 0: 574: 46.65		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		929893 ACTG_HUMAN (3-388): 0: 573: 46.37		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		930084 ACTH_HUMAN (1-388): 0: 569: 45.62		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		932198 ACTC_HUMAN (2-388): 0: 569: 46.51		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		932992 ACTS_HUMAN (2-388): 0: 569: 46.51		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		915405 ACTA_HUMAN (3-388): 0: 567: 45.86		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		201296 ACTG_HUMAN (3-388): 0: 573: 46.37		M3K7_HUMAN (1869-2143): 1.77e-23: 110: 30.14