HitPredict

Interactor 1: ACTZ (P61163)
Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog)
Gene: ACTR1A

Interactor 2: DC1I2 (Q13409)
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
Gene: DYNC1I2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28718761, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 638
+	Hs
		148056 ACTZ_HUMAN (1-376): 0: 771: 100.00		DC1I1_HUMAN (1-638): 2.67e-129: 396: 75.04
+	Hs
		785536 ACTY_HUMAN (1-376): 0: 728: 90.43		DC1I2_HUMAN (1-638): 3.3e-143: 432: 100.00
+	Hs
		929848 ACTG_HUMAN (7-376): 0: 580: 52.67		DC1I2_HUMAN (1-638): 3.3e-143: 432: 100.00
+	Hs
		897027 ACTZ_HUMAN (1-376): 0: 771: 100.00		WDR5_HUMAN (112-459): 1.1e-36: 141: 10.11
+	Hs
		891660 ACTB_HUMAN (7-376): 0: 580: 52.41		WDR5_HUMAN (112-459): 1.1e-36: 141: 10.11
+	Hs
		903110 ACTG_HUMAN (7-376): 0: 580: 52.67		WDR5_HUMAN (112-459): 1.1e-36: 141: 10.11
+	Hs
		792947 ACTB_HUMAN (7-376): 0: 580: 52.41		LIS1_HUMAN (472-631): 9.12e-32: 129: 16.88
+	Hs
		792968 ACTG_HUMAN (7-376): 0: 580: 52.67		LIS1_HUMAN (472-631): 9.12e-32: 129: 16.88
+	Hs
		932185 ACTC_HUMAN (5-376): 0: 576: 52.93		RBBP7_HUMAN (429-613): 3.4e-25: 110: 17.41