HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	18426980, 31871319
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001822 - kidney development GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 4655
+	Hs
		925190 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		893898 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		254256 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90
+	Hs
		254255 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90
+	Hs
		258304 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		915669 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		LRP8_HUMAN (3464-3669): 8.96e-14: 80.7: 21.92
+	Hs
		258305 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258303 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258292 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		270285 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30
+	Hs
		258302 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		270286 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30