HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 780
+	Hs
		436268 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		573648 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		573655 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		900407 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		436151 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		570514 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		436150 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTN2_HUMAN (24-401): 2.72e-123: 377: 23.85
+	Hs
		900436 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		925247 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		489936 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		489942 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		436285 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTPRS_HUMAN (8-299): 1.74e-91: 316: 31.65
+	Hs
		436131 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		660845 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTPRM_HUMAN (7-296): 8.79e-62: 228: 24.50
+	Hs
		900493 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		617094 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		617100 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		900420 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		925235 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		436276 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13