HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG05 (Q13017)
Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)
Gene: ARHGAP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	12842009, 32203420, 31871319
Identification Methods	affinity chromatography technology, pull down, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0003924 - GTPase activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1502
+	Hs
		900954 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG35_HUMAN (1-1479): 0: 1565: 49.43
+	Hs
		900443 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9B_HUMAN (792-1497): 8.58e-114: 400: 15.74
+	Hs
		70663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9A_HUMAN (956-1445): 1.69e-84: 309: 20.51
+	Hs
		900426 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ABR_HUMAN (862-1454): 1.28e-86: 304: 16.20
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (862-1454): 2.62e-87: 306: 15.71
+	Sc
		419696 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		RGA1_YEAST (981-1449): 9.06e-69: 254: 17.26
+	Hs
		900564 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG21_HUMAN (940-1500): 2.11e-71: 267: 16.43
+	Mm
		925802 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		CHIO_MOUSE (1192-1449): 1.01e-78: 265: 28.52
+	Hs
		900997 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		GMIP_HUMAN (1133-1498): 6.29e-71: 260: 23.12
+	Hs
		901000 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG23_HUMAN (795-1500): 1.02e-68: 257: 14.76
+	Mm
		925803 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG32_MOUSE (1148-1498): 2.97e-67: 253: 17.50
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (1175-1500): 9.32e-69: 248: 19.94
+	Mm
		925805 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		RHG22_MOUSE (1175-1498): 3.21e-68: 247: 20.88
+	Hs
		64681 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG32_HUMAN (1151-1498): 3.19e-63: 240: 18.21
+	Hs
		900637 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SRGP1_HUMAN (1140-1456): 1.35e-63: 239: 21.71
+	Hs
		900529 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG31_HUMAN (1243-1488): 1.51e-61: 234: 22.75
+	Hs
		49631 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG10_HUMAN (1277-1482): 1.1e-62: 232: 30.52
+	Hs
		901048 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG26_HUMAN (1185-1476): 8.87e-61: 226: 20.13
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (1250-1420): 2.54e-20: 100: 31.79
+	Mm
		925798 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		BCR_MOUSE (1250-1420): 2.74e-20: 100: 31.79