Protein: GRDN
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)

Gene: GRDN, CCDC88A
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q3V6T2

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0003779 - actin binding
GO:0005080 - protein kinase C binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005092 - GDP-dissociation inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1049352

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

729888

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.709

High

475976

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

4

7

Small-scale

0.700

High

966389

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

276690

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

5

High-throughput

0.667

High

459298

CATL1
Procathepsin L

3

4

High-throughput

0.667

High

971588

1433E
14-3-3 protein epsilon

3

8

High-throughput

0.667

High

1191491

JADE2
E3 ubiquitin-protein ligase Jade-2

3

6

High-throughput

0.667

High

691064

1433T
14-3-3 protein theta

3

20

High-throughput

0.650

High

728275

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.643

High

946124

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

320560

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

13

High-throughput

0.628

High

1101829

SKP2
S-phase kinase-associated protein 2

2

5

High-throughput

0.628

High

1191451

RPGF5
Rap guanine nucleotide exchange factor 5

2

2

High-throughput

0.628

High

363367

EGFR
Epidermal growth factor receptor

2

17

Small-scale

0.624

High

764802

CTNB1
Catenin beta-1

2

12

Small-scale

0.624

High

1191415

GRDN
Girdin

1

18

Small-scale

0.618

High

1191438

HOOK3
Protein Hook homolog 3

1

17

High-throughput

0.618

High

342900

HERC2
E3 ubiquitin-protein ligase HERC2

2

13

High-throughput

0.611

High

418676

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

7

High-throughput

0.611

High

848139

MAGA1
Melanoma-associated antigen 1

2

15

High-throughput

0.611

High

990289

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1191449

PARD3
Partitioning defective 3 homolog

2

16

High-throughput

0.611

High

1191416

RFTN2
Raftlin-2

2

0

High-throughput

0.602

High

1191479

NDEL1
Nuclear distribution protein nudE-like 1

2

16

High-throughput

0.590

High

1191492

DISC1
Disrupted in schizophrenia 1 protein

2

5

High-throughput

0.590

High

1191417

TFDP3
Transcription factor Dp family member 3

2

0

High-throughput

0.585

High

349108

LATS1
Serine/threonine-protein kinase LATS1

2

20

High-throughput

0.584

High

375568

RASK
GTPase KRas

2

20

High-throughput

0.584

High

604005

CXA1
Gap junction alpha-1 protein

2

9

Small-scale

0.584

High

614693

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

3

High-throughput

0.584

High

976302

RB11A
Ras-related protein Rab-11A

2

7

High-throughput

0.584

High

978046

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

711133

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.578

High

1191493

EXOC1
Exocyst complex component 1

2

2

High-throughput

0.576

High

552973

PIP
Prolactin-inducible protein

2

0

High-throughput

0.576

High

1099690

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

0

High-throughput

0.576

High

1191464

CC136
Coiled-coil domain-containing protein 136

2

17

High-throughput

0.574

High

439751

INSR
Insulin receptor

1

20

Small-scale

0.561

High

684495

CTNA2
Catenin alpha-2

1

5

Small-scale

0.561

High

578497

BRAF
Serine/threonine-protein kinase B-raf

1

12

High-throughput

0.541

High

605703

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

High-throughput

0.541

High

188298

HDAC3
Histone deacetylase 3

1

18

High-throughput

0.536

High

214581

WDR62
WD repeat-containing protein 62

1

17

High-throughput

0.536

High

323877

SC31A
Protein transport protein Sec31A

1

17

High-throughput

0.536

High

402943

ANXA1
Annexin A1

1

11

High-throughput

0.536

High

410881

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

15

High-throughput

0.536

High

445190

S10A6
Protein S100-A6

1

20

High-throughput

0.536

High

573124

KPYM
Pyruvate kinase PKM

1

1

High-throughput

0.536

High

682500

S100P
Protein S100-P

1

20

High-throughput

0.536

High

721011

CLIP1
CAP-Gly domain-containing linker protein 1

1

18

High-throughput

0.536

High

789124

NUP62
Nuclear pore glycoprotein p62

1

9

High-throughput

0.536

High

832906

CETN2
Centrin-2

1

2

High-throughput

0.536

High

856717

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.536

High

876597

NEST
Nestin

1

20

High-throughput

0.536

High

909025

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.536

High

920701

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

942029

PER3
Period circadian protein homolog 3

1

11

High-throughput

0.536

High

981514

RAN
GTP-binding nuclear protein Ran

1

15

High-throughput

0.536

High

1126230

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

1

High-throughput

0.536

High

1129142

IRF3
Interferon regulatory factor 3

1

4

High-throughput

0.536

High

1131278

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.536

High

1145578

RCN1
Reticulocalbin-1

1

10

High-throughput

0.536

High

1152080

MARE1
Microtubule-associated protein RP/EB family member 1

1

6

High-throughput

0.536

High

1191455

CELF1
CUGBP Elav-like family member 1

1

6

High-throughput

0.536

High

1191459

TRI52
E3 ubiquitin-protein ligase TRIM52

1

15

High-throughput

0.536

High

1191463

FUBP3
Far upstream element-binding protein 3

1

10

High-throughput

0.536

High

1191468

IWS1
Protein IWS1 homolog

1

15

High-throughput

0.536

High

1191473

SRSF8
Serine/arginine-rich splicing factor 8

1

9

High-throughput

0.536

High

1191476

RBM4
RNA-binding protein 4

1

13

High-throughput

0.536

High

1191477

DUS16
Dual specificity protein phosphatase 16

1

14

High-throughput

0.536

High

1191478

BACH2
Transcription regulator protein BACH2

1

13

High-throughput

0.536

High

1191490

DLRB1
Dynein light chain roadblock-type 1

1

1

High-throughput

0.536

High

1191501

CYH4
Cytohesin-4

1

3

High-throughput

0.536

High

163560

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.513

High

912185

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.513

High

1178822

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1191432

BRNP3
BMP/retinoic acid-inducible neural-specific protein 3

1

0

High-throughput

0.513

High

1191440

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.513

High

1191460

EME1
Structure-specific endonuclease subunit EME1

1

0

High-throughput

0.513

High

1191462

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

1191474

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

1191485

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1191509

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

778071

VGFR2
Vascular endothelial growth factor receptor 2

1

13

Small-scale

0.501

High

720244

UFO
Tyrosine-protein kinase receptor UFO

1

18

High-throughput

0.500

High

1191480

PRD14
PR domain zinc finger protein 14

1

5

Small-scale

0.500

High

706140

S10A2
Protein S100-A2

1

20

High-throughput

0.489

High

1191418

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.489

High

1191419

RBM26
RNA-binding protein 26

1

12

High-throughput

0.489

High

1191445

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

18

High-throughput

0.489

High

216178

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.479

High

122504

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

126628

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

172880

XPO1
Exportin-1

1

8

High-throughput

0.479

High

174250

ARHGA
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.479

High

189597

STX7
Syntaxin-7

1

9

High-throughput

0.479

High

213612

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.479

High

226049

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

241856

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

246634

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

247346

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

9

High-throughput

0.479

High

293774

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

299222

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

327283

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.479

High

338487

SC24B
Protein transport protein Sec24B

1

1

High-throughput

0.479

High

341068

DIRA3
GTP-binding protein Di-Ras3

1

12

High-throughput

0.479

High

341585

EYA4
Protein phosphatase EYA4

1

4

High-throughput

0.479

High

373965

RASN
GTPase NRas

1

20

High-throughput

0.479

High

412031

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

440097

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.479

High

463552

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

466289

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540478

LAMP1
Lysosome-associated membrane glycoprotein 1

1

12

High-throughput

0.479

High

541523

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

581085

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601313

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

627974

ANXA7
Annexin A7

1

11

High-throughput

0.479

High

640182

EPHA1
Ephrin type-A receptor 1

1

8

High-throughput

0.479

High

641186

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.479

High

642904

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

9

High-throughput

0.479

High

710278

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.479

High

711903

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

715609

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

730631

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764353

CTNA1
Catenin alpha-1

1

5

High-throughput

0.479

High

775128

FUS
RNA-binding protein FUS

1

8

High-throughput

0.479

High

789509

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

818741

CAPG
Macrophage-capping protein

1

15

High-throughput

0.479

High

845669

MUC18
Cell surface glycoprotein MUC18

1

12

High-throughput

0.479

High

857120

NSF
Vesicle-fusing ATPase

1

13

High-throughput

0.479

High

891181

GSK3A
Glycogen synthase kinase-3 alpha

1

16

High-throughput

0.479

High

891596

GSK3B
Glycogen synthase kinase-3 beta

1

18

High-throughput

0.479

High

910080

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

936344

AFAD
Afadin

1

20

High-throughput

0.479

High

953479

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955239

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956319

RAB2A
Ras-related protein Rab-2A

1

15

High-throughput

0.479

High

962112

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962756

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

967451

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

970602

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

973196

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

975064

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

984141

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

High-throughput

0.479

High

988410

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

988982

AP2B1
AP-2 complex subunit beta

1

13

High-throughput

0.479

High

1004074

CXAR
Coxsackievirus and adenovirus receptor

1

9

High-throughput

0.479

High

1015483

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1039107

RASF7
Ras association domain-containing protein 7

1

2

High-throughput

0.479

High

1041096

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1045352

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1087130

STX4
Syntaxin-4

1

9

High-throughput

0.479

High

1092144

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.479

High

1123651

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.479

High

1123920

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

12

High-throughput

0.479

High

1143138

PLEC
Plectin

1

20

High-throughput

0.479

High

1144927

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1151718

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1158863

RBBP7
Histone-binding protein RBBP7

1

17

High-throughput

0.479

High

1159499

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1159671

OCLN
Occludin

1

1

High-throughput

0.479

High

1178761

AAK1
AP2-associated protein kinase 1

1

15

High-throughput

0.479

High

1191420

MTCL3
Microtubule cross-linking factor 3

1

17

High-throughput

0.479

High

1191422

MT21C
Protein-lysine methyltransferase METTL21C

1

9

High-throughput

0.479

High

1191423

CP135
Centrosomal protein of 135 kDa

1

18

High-throughput

0.479

High

1191424

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.479

High

1191425

RNF43
E3 ubiquitin-protein ligase RNF43

1

10

High-throughput

0.479

High

1191426

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1191428

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1191429

PAXI1
PAX-interacting protein 1

1

17

High-throughput

0.479

High

1191430

MOB2
MOB kinase activator 2

1

6

High-throughput

0.479

High

1191433

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1191435

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.479

High

1191437

LUZP1
Leucine zipper protein 1

1

17

High-throughput

0.479

High

1191442

CXD3
Gap junction delta-3 protein

1

9

High-throughput

0.479

High

1191444

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

1191446

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1191447

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

1191450

MT21A
Protein N-lysine methyltransferase METTL21A

1

9

High-throughput

0.479

High

1191452

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

20

High-throughput

0.479

High

1191453

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1191454

KAT6A
Histone acetyltransferase KAT6A

1

14

High-throughput

0.479

High

1191456

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

19

High-throughput

0.479

High

1191457

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

20

High-throughput

0.479

High

1191461

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

1191465

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1191467

FMNL2
Formin-like protein 2

1

7

High-throughput

0.479

High

1191469

NUP88
Nuclear pore complex protein Nup88

1

1

High-throughput

0.479

High

1191470

BARD1
BRCA1-associated RING domain protein 1

1

12

High-throughput

0.479

High

1191471

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1191472

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1191475

CP250
Centrosome-associated protein CEP250

1

17

High-throughput

0.479

High

1191481

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

9

Small-scale

0.479

High

1191482

VP33B
Vacuolar protein sorting-associated protein 33B

1

4

High-throughput

0.479

High

1191483

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

1191484

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1191486

MOB1A
MOB kinase activator 1A

1

6

High-throughput

0.479

High

1191487

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1191488

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

9

High-throughput

0.479

High

1191489

E41LA
Band 4.1-like protein 4A

1

13

High-throughput

0.479

High

1191497

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

10

High-throughput

0.479

High

1191500

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1191502

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

1191503

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.479

High

1191504

MARE3
Microtubule-associated protein RP/EB family member 3

1

6

High-throughput

0.479

High

1191505

PHOCN
MOB-like protein phocein

1

6

High-throughput

0.479

High

1191506

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

5

High-throughput

0.479

High

1191507

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

2

Small-scale

0.479

High

1191508

SAR1B
Small COPII coat GTPase SAR1B

1

14

High-throughput

0.479

High

800215

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.458

High

982199

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

0

High-throughput

0.458

High

1191421

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1191436

PEG10
Retrotransposon-derived protein PEG10

1

0

Small-scale

0.458

High

1191439

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1191448

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

1191494

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

843619

HD
Huntingtin

1

4

High-throughput

0.457

High

1056765

FMR1
Fragile X messenger ribonucleoprotein 1

1

10

High-throughput

0.457

High

116748

I3L0N3
Vesicle-fusing ATPase

1

13

High-throughput

0.445

High

127100

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.445

High

765581

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

934694

TERA
Transitional endoplasmic reticulum ATPase

1

10

High-throughput

0.445

High

1191431

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

3

High-throughput

0.445

High

1191441

CNTRB
Centrobin

1

16

High-throughput

0.445

High

1191443

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

1191466

CEP63
Centrosomal protein of 63 kDa

1

17

High-throughput

0.445

High

1191495

PIHD1
PIH1 domain-containing protein 1

1

4

Small-scale

0.445

High

1191498

WRP73
WD repeat-containing protein WRAP73

1

16

High-throughput

0.445

High

1191499

SL9A2
Sodium/hydrogen exchanger 2

1

1

High-throughput

0.445

High

85268

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

1

Small-scale

0.437

High

1178129

QSER1
Glutamine and serine-rich protein 1

1

8

High-throughput

0.437

High

1191427

FBX42
F-box only protein 42

1

16

High-throughput

0.437

High

1191434

DET1
DET1 homolog

1

2

High-throughput

0.437

High

1191496

SEP10
Septin-10

1

6

High-throughput

0.437

High

76394

B4DT77
Annexin

1

11

High-throughput

0.407

High

76412

B4DU58
Macrophage-capping protein

1

15

High-throughput

0.407

High

1191458

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025