Protein: DAPLE
Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)

Gene: DAPLE, CCDC88C
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q9P219

Gene Ontology (top 5):
GO:0001578 - microtubule bundle formation
GO:0001965 - G-protein alpha-subunit binding
GO:0003383 - apical constriction
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005109 - frizzled binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476050

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

8

Small-scale

0.664

High

1309842

WDFY1
WD repeat and FYVE domain-containing protein 1

2

10

High-throughput

0.628

High

756385

MCM7
DNA replication licensing factor MCM7

3

18

High-throughput

0.609

High

296678

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

2

2

High-throughput

0.574

High

631525

RAB5A
Ras-related protein Rab-5A

2

7

High-throughput

0.571

High

270486

FZD7
Frizzled-7

1

2

Small-scale

0.561

High

299804

MPDZ
Multiple PDZ domain protein

1

12

Small-scale

0.561

High

282495

KTNA1
Katanin p60 ATPase-containing subunit A1

1

11

High-throughput

0.536

High

909216

NEK4
Serine/threonine-protein kinase Nek4

1

17

High-throughput

0.536

High

1431050

RNAS7
Ribonuclease 7

1

1

High-throughput

0.536

High

978366

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.533

High

853745

MK08
Mitogen-activated protein kinase 8

1

13

High-throughput

0.508

High

159404

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

20

Small-scale

0.501

High

247540

FZD6
Frizzled-6

1

2

Small-scale

0.501

High

423367

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

1322152

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

1418703

LOXE3
Hydroperoxide isomerase ALOXE3

1

2

High-throughput

0.489

High

1453436

ITSN2
Intersectin-2

1

14

High-throughput

0.481

High

1454229

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

270853

ROCK2
Rho-associated protein kinase 2

1

17

High-throughput

0.479

High

294456

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

347969

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

349270

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.479

High

355610

NSD2
Histone-lysine N-methyltransferase NSD2

1

15

Small-scale

0.479

High

463811

LYN
Tyrosine-protein kinase Lyn

1

11

High-throughput

0.479

High

650998

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

16

High-throughput

0.479

High

691496

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

730307

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

730931

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764455

CTNA1
Catenin alpha-1

1

6

High-throughput

0.479

High

765074

CTNB1
Catenin beta-1

1

15

High-throughput

0.479

High

936468

AFAD
Afadin

1

20

High-throughput

0.479

High

962582

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

966962

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

972083

1433E
14-3-3 protein epsilon

1

6

High-throughput

0.479

High

977847

ACTA
Actin, aortic smooth muscle

1

20

High-throughput

0.479

High

990814

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1049854

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1057011

FMR1
Fragile X messenger ribonucleoprotein 1

1

11

High-throughput

0.479

High

1108231

SQSTM
Sequestosome-1

1

9

Small-scale

0.479

High

1123850

DCTN1
Dynactin subunit 1

1

18

High-throughput

0.479

High

1124074

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

13

High-throughput

0.479

High

1226300

CP135
Centrosomal protein of 135 kDa

1

17

High-throughput

0.479

High

1353293

PARD3
Partitioning defective 3 homolog

1

15

High-throughput

0.479

High

1390310

TRI11
E3 ubiquitin-protein ligase TRIM11

1

10

Small-scale

0.479

High

1391198

BICD1
Protein bicaudal D homolog 1

1

19

High-throughput

0.479

High

1407605

TCPH
T-complex protein 1 subunit eta

1

11

High-throughput

0.479

High

1407924

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1438992

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

High-throughput

0.479

High

1448694

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.479

High

1454225

CLIP2
CAP-Gly domain-containing linker protein 2

1

19

High-throughput

0.479

High

1454226

ZRAN1
Ubiquitin thioesterase ZRANB1

1

17

High-throughput

0.479

High

1454227

NINL
Ninein-like protein

1

19

High-throughput

0.479

High

1383267

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

127198

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

650461

FGFR3
Fibroblast growth factor receptor 3

1

16

High-throughput

0.445

High

189891

STX7
Syntaxin-7

1

4

High-throughput

0.437

High

257006

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.437

High

358817

LDHA
L-lactate dehydrogenase A chain

1

5

High-throughput

0.437

High

502577

H2A1
Histone H2A type 1

1

20

High-throughput

0.437

High

687880

SYVC
Valine--tRNA ligase

1

5

High-throughput

0.437

High

971217

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

1092262

NFX1
Transcriptional repressor NF-X1

1

4

High-throughput

0.437

High

1232738

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.437

High

1372324

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.437

High

1401420

CIC
Protein capicua homolog

1

14

High-throughput

0.437

High

1454228

TR150
Thyroid hormone receptor-associated protein 3

1

14

High-throughput

0.437

High

87548

OSCRI
SCRIB overlapping open reading frame protein

1

2

High-throughput

0.407

High

411094

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.407

High

1411931

SIKE1
Suppressor of IKBKE 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025