HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG21 (Q5T5U3)
Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
Gene: ARHGAP21

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030054 - cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1958
+	Hs
		70663 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9A_HUMAN (397-1626): 2.37e-163: 559: 13.41
+	Hs
		900746 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARAP2_HUMAN (461-1674): 2.78e-114: 404: 13.08
+	Hs
		900443 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MYO9B_HUMAN (528-1527): 2.57e-108: 388: 12.88
+	Sc
		419696 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		RGA1_YEAST (540-1338): 2.84e-83: 299: 15.48
+	Hs
		49631 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG10_HUMAN (883-1558): 8.64e-95: 328: 17.84
+	Hs
		900954 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG35_HUMAN (750-1363): 4.7e-87: 317: 18.07
+	Hs
		900637 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SRGP1_HUMAN (1015-1671): 1.5e-88: 316: 18.66
+	Hs
		900540 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG29_HUMAN (906-1715): 6.23e-86: 311: 16.82
+	Hs
		64681 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG32_HUMAN (975-1909): 3.2e-84: 310: 16.63
+	Hs
		900871 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG39_HUMAN (510-1341): 1.78e-85: 307: 15.07
+	Mm
		1265268 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		SRGP1_MOUSE (1015-1724): 5.23e-85: 305: 17.63
+	Hs
		900429 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG05_HUMAN (750-1362): 9.1e-84: 306: 15.43
+	Hs
		900634 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG22_HUMAN (1022-1668): 1.98e-86: 301: 16.72
+	Hs
		901000 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG23_HUMAN (38-253): 6.95e-69: 259: 61.99
+	Hs
		900426 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ABR_HUMAN (1130-1341): 1.91e-65: 242: 34.55
+	Mm
		925793 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		ABR_MOUSE (1130-1341): 1.99e-65: 242: 34.55
+	Hs
		506561 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		BCR_HUMAN (1142-1311): 4.29e-23: 110: 40.00
+	Mm
		925798 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		BCR_MOUSE (1142-1311): 4.04e-23: 110: 40.00
+	Hs
		901048 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHG26_HUMAN (1164-1361): 1.51e-19: 97.8: 31.71
+	Hs
		245183 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		OPHN1_HUMAN (1168-1334): 2.19e-19: 97.4: 33.14