Protein: AXIN2
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)

Gene: AXIN2
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q9Y2T1

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001756 - somitogenesis
GO:0001957 - intramembranous ossification
GO:0003139 - secondary heart field specification
GO:0003180 - aortic valve morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891901

GSK3B
Glycogen synthase kinase-3 beta

11

8

Small-scale

0.977

High

891367

GSK3A
Glycogen synthase kinase-3 alpha

4

7

High-throughput

0.902

High

765142

CTNB1
Catenin beta-1

4

8

Small-scale

0.867

High

1490641

FBW1A
F-box/WD repeat-containing protein 1A

2

4

High-throughput

0.783

High

181195

AXIN1
Axin-1

2

7

Small-scale

0.737

High

353781

APCL
Adenomatous polyposis coli protein 2

1

11

Small-scale

0.621

High

1307819

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

2

Small-scale

0.619

High

603392

KPCA
Protein kinase C alpha type

1

4

High-throughput

0.618

High

668763

APC
Adenomatous polyposis coli protein

1

12

Small-scale

0.618

High

920384

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.618

High

1461011

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.618

High

1490911

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

6

Small-scale

0.618

High

286743

STX11
Syntaxin-11

2

3

High-throughput

0.606

High

478742

HXB5
Homeobox protein Hox-B5

2

8

High-throughput

0.606

High

821225

TXLNA
Alpha-taxilin

2

6

High-throughput

0.606

High

887744

PSB2
Proteasome subunit beta type-2

2

1

High-throughput

0.606

High

948728

KR10A
Keratin-associated protein 10-10

2

13

High-throughput

0.606

High

950731

KR108
Keratin-associated protein 10-8

2

12

High-throughput

0.606

High

1143918

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

2

High-throughput

0.606

High

1150191

TCEA2
Transcription elongation factor A protein 2

2

1

High-throughput

0.606

High

1156282

ZN124
Zinc finger protein 124

2

2

High-throughput

0.606

High

1213262

ZN648
Zinc finger protein 648

2

1

High-throughput

0.606

High

1325263

TXLNB
Beta-taxilin

2

12

High-throughput

0.606

High

1331121

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

2

High-throughput

0.606

High

1347751

ZN417
Zinc finger protein 417

2

2

High-throughput

0.606

High

1348585

LNX1
E3 ubiquitin-protein ligase LNX

2

7

High-throughput

0.606

High

1402965

ZN587
Zinc finger protein 587

2

2

High-throughput

0.606

High

1406810

BARD1
BRCA1-associated RING domain protein 1

2

8

High-throughput

0.606

High

1415264

KIFC3
Kinesin-like protein KIFC3

2

7

High-throughput

0.606

High

1419043

KRA92
Keratin-associated protein 9-2

2

12

High-throughput

0.606

High

1419078

KRA45
Keratin-associated protein 4-5

2

12

High-throughput

0.606

High

1420319

TSG10
Testis-specific gene 10 protein

2

8

High-throughput

0.606

High

1449662

RN146
E3 ubiquitin-protein ligase RNF146

2

1

Small-scale

0.601

High

177733

SMAD7
Mothers against decapentaplegic homolog 7

2

7

Small-scale

0.595

High

977616

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

5

Small-scale

0.586

High

289376

CTAG2
Cancer/testis antigen 2

2

0

High-throughput

0.580

High

352605

TOP3B
DNA topoisomerase 3-beta-1

2

0

High-throughput

0.580

High

1119047

BYST
Bystin

2

0

High-throughput

0.580

High

1185347

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1337400

CC112
Coiled-coil domain-containing protein 112

2

0

High-throughput

0.580

High

1390196

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1416202

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1417332

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.580

High

1461111

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

0

High-throughput

0.580

High

1490913

CAN7
Calpain-7

2

0

High-throughput

0.580

High

1432029

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

6

Small-scale

0.571

High

1124439

ELOA1
Elongin-A

2

2

High-throughput

0.553

High

1490707

ANKR6
Ankyrin repeat domain-containing protein 6

1

9

Small-scale

0.552

High

144148

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

1

High-throughput

0.541

High

482563

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.541

High

854766

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.541

High

900236

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

900564

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

1154030

SMAD1
Mothers against decapentaplegic homolog 1

1

7

High-throughput

0.541

High

1331514

AMER3
APC membrane recruitment protein 3

1

1

Small-scale

0.536

High

1106758

SMAD4
Mothers against decapentaplegic homolog 4

1

8

High-throughput

0.529

High

295047

ZN189
Zinc finger protein 189

1

0

High-throughput

0.518

High

376932

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.518

High

1057288

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.518

High

1437903

KCNKC
Potassium channel subfamily K member 12

1

0

High-throughput

0.518

High

1086943

CDC20
Cell division cycle protein 20 homolog

1

3

Small-scale

0.515

High

1372349

H2B1H
Histone H2B type 1-H

1

4

High-throughput

0.515

High

1197135

AMOT
Angiomotin

1

3

High-throughput

0.481

High

1150384

TGIF1
Homeobox protein TGIF1

1

1

Small-scale

0.481

High

447601

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

652602

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

Small-scale

0.479

High

943435

H2BFS
Histone H2B type F-S

1

4

High-throughput

0.479

High

1142036

EEA1
Early endosome antigen 1

1

4

High-throughput

0.479

High

1252790

RN111
E3 ubiquitin-protein ligase Arkadia

1

3

Small-scale

0.479

High

1449220

KIF15
Kinesin-like protein KIF15

1

7

Small-scale

0.479

High

1450917

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

Small-scale

0.479

High

1490912

AMMR1
Nuclear protein AMMECR1

1

1

Small-scale

0.479

High

59939

A2BDD9
AMOT protein

1

5

High-throughput

0.470

High

791862

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

303666

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.458

High

1459583

KDM5B
Lysine-specific demethylase 5B

1

0

Small-scale

0.458

High

332464

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

6

Small-scale

0.445

High

1179272

CB068
UPF0561 protein C2orf68

2

0

High-throughput

0.316

High

1180522

C19L2
CWF19-like protein 2

2

0

High-throughput

0.316

High

1417010

HEMGN
Hemogen

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025