Protein: AXIN1
Axin-1 (Axis inhibition protein 1) (hAxin)

Gene: AXIN1
Organism: Homo sapiens
Interactions: 179
UniProt ID: O15169

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001701 - in utero embryonic development
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181076

GSK3B
Glycogen synthase kinase-3 beta

47

7

Small-scale

0.996

High

181063

CTNB1
Catenin beta-1

32

7

Small-scale

0.992

High

181057

APC
Adenomatous polyposis coli protein

13

11

Small-scale

0.980

High

181075

GSK3A
Glycogen synthase kinase-3 alpha

12

6

Small-scale

0.979

High

159421

DVL2
Segment polarity protein dishevelled homolog DVL-2

7

16

Small-scale

0.956

High

181194

FBW1A
F-box/WD repeat-containing protein 1A

7

4

Small-scale

0.952

High

181032

AXIN1
Axin-1

6

7

Small-scale

0.948

High

181101

M3K1
Mitogen-activated protein kinase kinase kinase 1

5

8

Small-scale

0.902

High

181072

KC1E
Casein kinase I isoform epsilon

4

6

Small-scale

0.884

High

181069

KC1A
Casein kinase I isoform alpha

4

3

Small-scale

0.860

High

181147

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

14

Small-scale

0.847

High

181192

FBW1B
F-box/WD repeat-containing protein 11

3

4

Small-scale

0.847

High

159293

DVL1
Segment polarity protein dishevelled homolog DVL-1

3

17

Small-scale

0.827

High

181174

HIPK2
Homeodomain-interacting protein kinase 2

3

3

Small-scale

0.827

High

181051

PLAK
Junction plakoglobin

2

8

High-throughput

0.817

High

181177

WDR26
WD repeat-containing protein 26

2

5

Small-scale

0.773

High

181038

LRP6
Low-density lipoprotein receptor-related protein 6

8

5

Small-scale

0.746

High

181195

AXIN2
Axin-2

2

7

Small-scale

0.737

High

181082

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

20

Small-scale

0.724

High

181120

AMER1
APC membrane recruitment protein 1

4

1

Small-scale

0.698

High

171631

GAK
Cyclin-G-associated kinase

1

1

High-throughput

0.698

High

181157

SCYL1
N-terminal kinase-like protein

1

2

High-throughput

0.698

High

181070

KC1D
Casein kinase I isoform delta

1

5

High-throughput

0.691

High

181201

WSB1
WD repeat and SOCS box-containing protein 1

1

0

Small-scale

0.687

High

181041

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

4

6

Small-scale

0.683

High

181093

CALD1
Caldesmon

4

4

High-throughput

0.683

High

181114

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

3

2

Small-scale

0.681

High

181085

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

5

Small-scale

0.678

High

181044

P53
Cellular tumor antigen p53

3

1

Small-scale

0.675

High

181149

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

4

Small-scale

0.667

High

181179

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

1

Small-scale

0.653

High

181036

LRP5
Low-density lipoprotein receptor-related protein 5

3

5

Small-scale

0.640

High

181138

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

2

Small-scale

0.640

High

181098

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.618

High

181196

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

6

Small-scale

0.618

High

181202

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

8

Small-scale

0.618

High

181144

TSC1
Hamartin

2

6

Small-scale

0.614

High

181068

YAP1
Transcriptional coactivator YAP1

2

5

Small-scale

0.611

High

181162

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.602

High

181154

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

177628

SMAD7
Mothers against decapentaplegic homolog 7

2

7

Small-scale

0.601

High

181173

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

6

Small-scale

0.595

High

181131

RN111
E3 ubiquitin-protein ligase Arkadia

2

3

Small-scale

0.586

High

181197

STRAP
Serine-threonine kinase receptor-associated protein

1

0

Small-scale

0.586

High

181060

PML
Protein PML

1

4

Small-scale

0.578

High

181111

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.578

High

181124

RNF43
E3 ubiquitin-protein ligase RNF43

2

0

Small-scale

0.576

High

181043

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.571

High

181047

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.571

High

181183

GID8
Glucose-induced degradation protein 8 homolog

2

3

Small-scale

0.571

High

181065

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

High-throughput

0.568

High

181109

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.568

High

181178

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

1

Small-scale

0.561

High

181074

TSC2
Tuberin

2

0

Small-scale

0.559

High

181148

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

Small-scale

0.552

High

181059

MK03
Mitogen-activated protein kinase 3

1

0

Small-scale

0.546

High

181037

STX11
Syntaxin-11

1

3

High-throughput

0.541

High

181039

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.541

High

181050

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.541

High

181078

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

181079

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

181084

SUMO1
Small ubiquitin-related modifier 1

1

3

High-throughput

0.541

High

181095

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.541

High

181096

TRAF2
TNF receptor-associated factor 2

1

4

High-throughput

0.541

High

181099

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.541

High

181116

TRIP6
Thyroid receptor-interacting protein 6

1

4

High-throughput

0.541

High

181118

CCD57
Coiled-coil domain-containing protein 57

1

4

High-throughput

0.541

High

181119

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

6

High-throughput

0.541

High

181126

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.541

High

181150

LHX4
LIM/homeobox protein Lhx4

1

4

High-throughput

0.541

High

181156

ANCHR
Abscission/NoCut checkpoint regulator

1

2

High-throughput

0.541

High

181161

MDFI
MyoD family inhibitor

1

1

High-throughput

0.541

High

181164

KR412
Keratin-associated protein 4-12

1

13

High-throughput

0.541

High

181165

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.541

High

181166

KRA42
Keratin-associated protein 4-2

1

12

High-throughput

0.541

High

181169

TRI15
E3 ubiquitin-protein ligase TRIM15

1

3

High-throughput

0.541

High

181172

CARD9
Caspase recruitment domain-containing protein 9

1

6

High-throughput

0.541

High

181185

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.541

High

181191

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

10

High-throughput

0.541

High

181146

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.537

High

181158

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

Small-scale

0.537

High

181200

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.537

High

181071

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.536

High

181112

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

3

High-throughput

0.536

High

181081

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

Small-scale

0.534

High

181187

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.529

High

181033

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.518

High

181086

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

181186

MYOTI
Myotilin

1

0

High-throughput

0.518

High

181052

H15
Histone H1.5

1

4

High-throughput

0.515

High

181053

H12
Histone H1.2

1

4

High-throughput

0.515

High

181123

DAB2P
Disabled homolog 2-interacting protein

1

1

Small-scale

0.515

High

181134

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

181062

CTNA1
Catenin alpha-1

1

0

High-throughput

0.513

High

181105

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.513

High

181117

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

181121

RHG21
Rho GTPase-activating protein 21

1

0

High-throughput

0.513

High

181176

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

181193

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.513

High

181089

DAB2
Disabled homolog 2

1

3

Small-scale

0.501

High

181136

CARM1
Histone-arginine methyltransferase CARM1

1

4

Small-scale

0.501

High

181115

TGIF1
Homeobox protein TGIF1

1

1

Small-scale

0.500

High

181180

ZBT26
Zinc finger and BTB domain-containing protein 26

1

5

High-throughput

0.494

High

181045

H10
Histone H1.0

1

0

High-throughput

0.493

High

181055

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.493

High

181143

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.493

High

181181

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.493

High

181056

TBG1
Tubulin gamma-1 chain

1

5

Small-scale

0.484

High

181058

RBTN2
Rhombotin-2

1

4

High-throughput

0.481

High

181066

ETV6
Transcription factor ETV6

1

1

High-throughput

0.481

High

181077

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.481

High

181080

KR103
Keratin-associated protein 10-3

1

12

High-throughput

0.481

High

181106

ASPP2
Apoptosis-stimulating of p53 protein 2

1

8

High-throughput

0.481

High

181110

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.481

High

181125

LHX8
LIM/homeobox protein Lhx8

1

2

High-throughput

0.481

High

181141

HOMEZ
Homeobox and leucine zipper protein Homez

1

2

High-throughput

0.481

High

181153

CDA7L
Cell division cycle-associated 7-like protein

1

1

High-throughput

0.481

High

181155

GMCL1
Germ cell-less protein-like 1

1

4

High-throughput

0.481

High

181168

TSG10
Testis-specific gene 10 protein

1

8

High-throughput

0.481

High

181064

PPM1A
Protein phosphatase 1A

1

0

Small-scale

0.479

High

172268

XPO1
Exportin-1

1

4

High-throughput

0.479

High

181034

NCK2
Cytoplasmic protein NCK2

1

3

Small-scale

0.479

High

181035

PRC1
Protein regulator of cytokinesis 1

1

2

Small-scale

0.479

High

181040

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

181046

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

181048

SKI
Ski oncogene

1

1

Small-scale

0.479

High

181049

SKIL
Ski-like protein

1

1

Small-scale

0.479

High

181054

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.479

High

181067

HD
Huntingtin

1

3

Small-scale

0.479

High

181091

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

181104

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

181107

TRI29
Tripartite motif-containing protein 29

1

9

Small-scale

0.479

High

181129

TRI65
E3 ubiquitin-protein ligase TRIM65

1

5

Small-scale

0.479

High

181152

TRI11
E3 ubiquitin-protein ligase TRIM11

1

3

Small-scale

0.479

High

181167

TRI54
Tripartite motif-containing protein 54

1

9

Small-scale

0.479

High

181171

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

1

Small-scale

0.479

High

181182

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.479

High

181184

DACT1
Dapper homolog 1

1

1

Small-scale

0.479

High

181188

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

181190

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.479

High

181198

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

181199

AMMR1
Nuclear protein AMMECR1

1

1

Small-scale

0.479

High

181137

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

181087

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

181090

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

181094

FOXM1
Forkhead box protein M1

1

0

Small-scale

0.458

High

181102

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.458

High

181128

LTOR1
Ragulator complex protein LAMTOR1

1

0

Small-scale

0.458

High

181135

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.458

High

181160

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

181189

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

Small-scale

0.458

High

107786

SUMO5
Small ubiquitin-related modifier 5

1

3

High-throughput

0.457

High

181127

Q6FHY5
MEOX2 protein

1

5

High-throughput

0.457

High

181163

SH3G1
Endophilin-A2

1

3

High-throughput

0.457

High

181061

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

Small-scale

0.445

High

181083

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.445

High

181092

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.445

High

181097

DLG1
Disks large homolog 1

1

3

Small-scale

0.445

High

181100

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

Small-scale

0.445

High

181103

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

2

Small-scale

0.445

High

181113

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

Small-scale

0.445

High

181130

RBP10
Ran-binding protein 10

1

2

Small-scale

0.445

High

181132

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

Small-scale

0.445

High

181133

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

Small-scale

0.445

High

181142

NIN
Ninein

1

4

Small-scale

0.445

High

181159

RANB9
Ran-binding protein 9

1

2

Small-scale

0.445

High

181170

WWTR1
WW domain-containing transcription regulator protein 1

1

5

Small-scale

0.445

High

181140

TRI42
Tripartite motif-containing protein 42

1

10

High-throughput

0.439

High

181151

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.439

High

181042

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

181073

RBP2
E3 SUMO-protein ligase RanBP2

1

0

Small-scale

0.426

High

181108

TFDP1
Transcription factor Dp-1

1

0

Small-scale

0.426

High

181122

ZN318
Zinc finger protein 318

1

0

Small-scale

0.426

High

181139

PHF6
PHD finger protein 6

1

0

Small-scale

0.426

High

181145

FRAT1
Proto-oncogene FRAT1

1

0

Small-scale

0.426

High

181175

YTDC2
3'-5' RNA helicase YTHDC2

1

0

Small-scale

0.426

High

97144

E9PQ56
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.407

High

181088

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025