HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RGPA1 (Q6GYQ0)
Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)
Gene: RALGAPA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 2036
+	Hs
		925359 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		951081 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		894131 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		892432 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		915756 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		951036 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RGPA2_HUMAN (1-2030): 0: 2671: 49.46
+	Hs
		915714 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		RGPA2_HUMAN (1-2030): 0: 2671: 49.46
+	Hs
		900790 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		SIPA1_HUMAN (1603-2018): 1.13e-117: 402: 16.91
+	Hs
		925514 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SIPA1_HUMAN (1603-2018): 1.13e-117: 402: 16.91
+	Hs
		900651 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		925407 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		951126 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		894180 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		196428 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		SI1L1_HUMAN (1683-2015): 2.28e-106: 380: 19.22
+	Hs
		230233 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		SI1L3_HUMAN (1691-2016): 1.32e-100: 362: 18.83
+	Dm
		776929 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		X2JDH0_DROME (1637-2013): 4.12e-102: 367: 21.16
+	Dm
		776932 RAC1_DROME (1-193): 2.11e-77: 231: 54.12		X2JJU0_DROME (1637-2013): 3.69e-102: 367: 21.16
+	Hs
		892464 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		230232 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		SI1L3_HUMAN (1691-2016): 1.32e-100: 362: 18.83
+	Hs
		835036 RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94		TSC2_HUMAN (1727-2033): 1.18e-96: 349: 23.90