HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF_assoc_1~Ras, Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 618
+	Hs
		545301 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		545309 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		892307 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		893858 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Mm
		892717 RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22		CDC42_MOUSE (3-172): 5.67e-77: 244: 25.54
+	Hs
		893879 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		900494 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70
+	Hs
		900374 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Mm
		925823 RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48		RAC1_MOUSE (3-181): 3.15e-74: 237: 26.43
+	Hs
		900355 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1A_HUMAN (416-593): 1.56e-40: 148: 18.28
+	Hs
		900882 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1B_HUMAN (416-578): 8.51e-39: 143: 19.05
+	Hs
		894710 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB8A_HUMAN (411-594): 7.98e-27: 110: 15.34
+	Hs
		894716 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB8A_HUMAN (411-594): 7.98e-27: 110: 15.34
+	Hs
		900511 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RB11B_HUMAN (416-572): 8.06e-22: 96.2: 20.37
+	Hs
		900354 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900345 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		900926 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		436237 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		120376 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89