Protein: TRFL
Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]

Gene: TRFL, LTF
Organism: Homo sapiens
Interactions: 149
UniProt ID: P02788

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0001530 - lipopolysaccharide binding
GO:0001817 - regulation of cytokine production
GO:0002227 - innate immune response in mucosa
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364750

SIRPG
Signal-regulatory protein gamma

2

2

High-throughput

0.789

High

364753

DPOLL
DNA polymerase lambda

3

1

High-throughput

0.656

High

364723

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

364739

DDX31
ATP-dependent DNA helicase DDX31

2

2

High-throughput

0.628

High

364756

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

364726

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

364645

ZN250
Zinc finger protein 250

2

0

High-throughput

0.585

High

364658

CEBPA
CCAAT/enhancer-binding protein alpha

2

4

Small-scale

0.584

High

364682

CEBPE
CCAAT/enhancer-binding protein epsilon

2

4

Small-scale

0.584

High

364687

HBM
Hemoglobin subunit mu

2

2

High-throughput

0.574

High

364672

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.547

High

364691

RHGBA
Rho GTPase-activating protein 11A

2

0

High-throughput

0.547

High

364639

CD14
Monocyte differentiation antigen CD14

1

0

Small-scale

0.537

High

134511

FCN1
Ficolin-1

1

2

High-throughput

0.536

High

180532

MAGB4
Melanoma-associated antigen B4

1

1

High-throughput

0.536

High

197871

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

198359

KLK10
Kallikrein-10

1

4

High-throughput

0.536

High

240470

GALR3
Galanin receptor type 3

1

2

High-throughput

0.536

High

364643

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

364646

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.536

High

364651

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

364655

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.536

High

364661

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.536

High

364662

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.536

High

364663

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.536

High

364693

AEBP2
Zinc finger protein AEBP2

1

1

High-throughput

0.536

High

364696

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

High-throughput

0.536

High

364699

TEX14
Inactive serine/threonine-protein kinase TEX14

1

1

High-throughput

0.536

High

364712

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.536

High

364713

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

364722

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

364729

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

364732

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

364744

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.536

High

364754

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

364759

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

116952

SGK1
Serine/threonine-protein kinase Sgk1

1

1

High-throughput

0.515

High

127090

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.513

High

364648

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

364649

MAK
Serine/threonine-protein kinase MAK

1

0

High-throughput

0.513

High

364652

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.513

High

364660

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.513

High

364673

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

364683

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

364689

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

High-throughput

0.513

High

364695

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.513

High

364698

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.513

High

364701

APCD1
Protein APCDD1

1

0

High-throughput

0.513

High

364704

LRC17
Leucine-rich repeat-containing protein 17

1

0

High-throughput

0.513

High

364706

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.513

High

364707

AT11C
Phospholipid-transporting ATPase IG

1

0

High-throughput

0.513

High

364709

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.513

High

364711

MK15
Mitogen-activated protein kinase 15

1

0

High-throughput

0.513

High

364715

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

364718

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.513

High

364719

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.513

High

364724

PRAP1
Proline-rich acidic protein 1

1

0

High-throughput

0.513

High

364734

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.513

High

364741

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.513

High

364742

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

364743

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.513

High

327759

EPPI
Eppin

1

1

Small-scale

0.501

High

336757

CERU
Ceruloplasmin

1

1

Small-scale

0.501

High

364640

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

364714

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

364736

ACE2
Angiotensin-converting enzyme 2

1

1

Small-scale

0.501

High

364665

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.493

High

49088

DHR12
Dehydrogenase/reductase SDR family member 12

1

1

High-throughput

0.489

High

312699

CXB5
Gap junction beta-5 protein

1

3

High-throughput

0.489

High

364690

SFXN4
Sideroflexin-4

1

2

High-throughput

0.489

High

364716

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

364717

PF21B
PHD finger protein 21B

1

5

High-throughput

0.489

High

364721

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.489

High

364731

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

364748

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

1

1

High-throughput

0.489

High

364647

NUCL
Nucleolin

1

0

Small-scale

0.480

High

364667

LYSC
Lysozyme C

1

0

Small-scale

0.480

High

364710

MUC7
Mucin-7

1

0

Small-scale

0.480

High

125074

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

226218

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

282461

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

345643

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

364635

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

364636

S10A8
Protein S100-A8

1

1

High-throughput

0.479

High

364638

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

364642

CLUS
Clusterin

1

1

Small-scale

0.479

High

364650

PRTN3
Myeloblastin

1

3

High-throughput

0.479

High

364654

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

364659

CEBPD
CCAAT/enhancer-binding protein delta

1

4

Small-scale

0.479

High

364674

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

364677

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

364679

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

364688

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

364694

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

364725

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.479

High

364730

NECD
Necdin

1

1

High-throughput

0.479

High

364735

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

364751

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

364755

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

364757

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

364760

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

364762

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

133826

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

231950

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

256195

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.458

High

364637

PERM
Myeloperoxidase

1

0

High-throughput

0.458

High

364644

HIS3
Histatin-3

1

0

Small-scale

0.458

High

364656

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

364657

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

364664

EFNA3
Ephrin-A3

1

0

High-throughput

0.458

High

364666

EPHA4
Ephrin type-A receptor 4

1

0

High-throughput

0.458

High

364668

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

364670

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

364671

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

364676

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

364680

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

364720

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

364728

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

364745

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

364747

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

364761

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

364641

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

364675

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

364678

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

364681

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.445

High

364685

Q5JQP4
DNA polymerase

1

1

High-throughput

0.445

High

364703

CD177
CD177 antigen

1

1

Small-scale

0.445

High

364737

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

364752

RCOR3
REST corepressor 3

1

1

High-throughput

0.437

High

200463

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

364686

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

364708

CC148
Coiled-coil domain-containing protein 148

3

0

High-throughput

0.347

High

364740

KT3K
Ketosamine-3-kinase

3

0

High-throughput

0.347

High

364705

FRMD1
FERM domain-containing protein 1

2

0

High-throughput

0.328

High

364727

TM237
Transmembrane protein 237

2

0

High-throughput

0.318

High

64481

GOG8A
Golgin subfamily A member 8A

1

0

High-throughput

0.279

Low

330380

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

364653

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.279

Low

364669

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

364684

T176B
Transmembrane protein 176B

1

0

High-throughput

0.279

Low

364692

SPNS3
Protein spinster homolog 3

1

0

High-throughput

0.279

Low

364700

ELOA2
Elongin-A2

1

0

High-throughput

0.279

Low

364702

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.279

Low

364733

RSLBB
Ras-like protein family member 11B

1

0

High-throughput

0.279

Low

364738

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

364697

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

364746

ANLN
Anillin

1

0

High-throughput

0.249

Low

364749

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

364758

NINL
Ninein-like protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024