HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35760846
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 581
+	Hs
		783965 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		783972 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		436188 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		783983 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		783964 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		545242 RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Mm
		892726 CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33		KPCI_MOUSE (56-568): 8.1e-122: 373: 13.22
+	Hs
		783963 RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54		KPCI_HUMAN (56-568): 6.26e-123: 376: 13.92
+	Hs
		681775 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		AKT1_HUMAN (115-573): 2.58e-118: 360: 12.89
+	Hs
		900405 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Hs
		925221 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Rn
		88510 RHOA_RAT (1-193): 4.1e-81: 240: 99.48		D3Z9M9_RAT (1-244): 6.72e-116: 346: 77.46
+	Hs
		893928 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KPCZ_HUMAN (54-568): 6.17e-114: 353: 13.97
+	Hs
		568611 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		568619 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		436148 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Dm
		54649 CDC42_DROME (1-193): 4.33e-75: 225: 51.30		APKC_DROME (56-568): 3.79e-110: 343: 12.57
+	Hs
		568605 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		850632 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KS6A3_HUMAN (154-555): 2.08e-92: 301: 16.59
+	Hs
		925229 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DMPK_HUMAN (314-498): 7.75e-46: 172: 29.02