HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	10523675, 32203420
Identification Methods	pull down, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 847
+	Hs
		548672 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		855779 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Ce
		975575 RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44		VAV_CAEEL (2-847): 1.48e-120: 390: 22.17
+	Hs
		900916 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ECT2_HUMAN (101-625): 2.68e-83: 287: 18.71
+	Hs
		166479 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2L_HUMAN (25-656): 1.17e-78: 278: 16.12
+	Hs
		166482 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MCF2L_HUMAN (25-656): 1.17e-78: 278: 16.12
+	Hs
		900718 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX1_HUMAN (144-616): 2.28e-75: 270: 19.65
+	Hs
		900913 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG2_HUMAN (123-811): 2.39e-73: 264: 15.63
+	Hs
		50573 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PKHG3_HUMAN (100-672): 2.7e-73: 263: 16.26
+	Hs
		900947 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHG4_HUMAN (138-579): 1.38e-75: 262: 18.02
+	Hs
		50580 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		PKHG3_HUMAN (100-672): 2.7e-73: 263: 16.26
+	Hs
		900616 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PREX2_HUMAN (181-616): 3.85e-71: 258: 20.39
+	Hs
		500932 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		MCF2_HUMAN (30-616): 2.14e-72: 257: 15.19
+	Hs
		500934 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		MCF2_HUMAN (30-616): 2.14e-72: 257: 15.19
+	Hs
		224711 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		KALRN_HUMAN (152-705): 9.15e-54: 205: 14.14
+	Hs
		279851 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29
+	Hs
		279854 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29
+	Hs
		900813 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		ARHGH_HUMAN (179-435): 2.61e-18: 92.8: 27.72
+	Hs
		580968 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Gg
		1141019 Q6LC82_CHICK (1-193): 8.86e-80: 237: 57.22		ARHG6_CHICK (737-847): 1.47e-14: 79.8: 24.32