HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RAP2C (Q9Y3L5)
Ras-related protein Rap-2c (EC 3.6.5.2)
Gene: RAP2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0005829 - cytosol GO:0005886 - plasma membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 183
+	Hs
		925756 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAP2C_HUMAN (1-183): 6.64e-85: 249: 100.00
+	Hs
		436584 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAP2C_HUMAN (1-183): 6.64e-85: 249: 100.00
+	Hs
		897979 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAP2B_HUMAN (1-182): 1.79e-79: 235: 86.26
+	Hs
		897874 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAP1B_HUMAN (1-180): 2.46e-77: 230: 60.77
+	Hs
		900355 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1A_HUMAN (4-170): 1.34e-76: 229: 35.71
+	Hs
		897878 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAP1B_HUMAN (1-180): 2.46e-77: 230: 60.77
+	Hs
		900882 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB1B_HUMAN (4-179): 2.04e-76: 228: 33.33
+	Hs
		918847 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB1A_HUMAN (4-170): 1.34e-76: 229: 35.71
+	Hs
		925600 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RAB1B_HUMAN (4-179): 2.04e-76: 228: 33.33
+	Hs
		436236 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAP1B_HUMAN (1-180): 2.46e-77: 230: 60.77
+	Hs
		436244 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB1A_HUMAN (4-170): 1.34e-76: 229: 35.71
+	Hs
		436498 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RAB1B_HUMAN (4-179): 2.04e-76: 228: 33.33
+	Hs
		893855 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RAP1B_HUMAN (1-180): 2.46e-77: 230: 60.77
+	Hs
		918849 RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40		RAB1A_HUMAN (4-170): 1.34e-76: 229: 35.71
+	Hs
		896602 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RAB14_HUMAN (4-183): 1.1e-72: 219: 30.39
+	Hs
		913995 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RB11A_HUMAN (4-177): 1.26e-72: 219: 29.71
+	Hs
		925495 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		RIT1_HUMAN (2-164): 2.8e-55: 176: 49.08
+	Hs
		506377 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		RALA_HUMAN (4-164): 1.06e-47: 155: 45.96
+	Hs
		436135 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		RALA_HUMAN (4-164): 1.06e-47: 155: 45.96
+	Hs
		506374 CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33		RALA_HUMAN (4-164): 1.06e-47: 155: 45.96