HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: DAAM1 (Q9Y4D1)
Disheveled-associated activator of morphogenesis 1
Gene: DAAM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	28514442, 33961781, 31871319, 18162551, 34591642, 18218625
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, surface plasmon resonance, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1078
+	Hs
		925759 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DAAM1_HUMAN (1-1078): 0: 978: 100.00
+	Hs
		436379 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DAAM2_HUMAN (1-1078): 0: 896: 65.45
+	Hs
		900958 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP3_HUMAN (19-1076): 0: 715: 24.95
+	Hs
		925658 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP3_HUMAN (19-1076): 0: 715: 24.95
+	Hs
		900815 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL2_HUMAN (45-1049): 0: 588: 22.77
+	Hs
		925531 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL2_HUMAN (45-1049): 0: 588: 22.77
+	Hs
		925768 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FHOD1_HUMAN (47-1069): 0: 581: 17.06
+	Hs
		900661 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL3_HUMAN (46-1049): 2.93e-178: 550: 21.61
+	Hs
		314854 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMNL1_HUMAN (163-1055): 7.47e-177: 548: 22.82
+	Hs
		900525 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		INF2_HUMAN (103-1069): 1.2e-174: 547: 22.85
+	Hs
		314858 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMNL1_HUMAN (163-1055): 7.47e-177: 548: 22.82
+	Hs
		925315 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		INF2_HUMAN (103-1069): 1.2e-174: 547: 22.85
+	Hs
		436333 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		INF2_HUMAN (103-1069): 1.2e-174: 547: 22.85
+	Hs
		243097 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP2_HUMAN (594-1071): 1.17e-108: 366: 28.31
+	Hs
		243100 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP2_HUMAN (594-1071): 1.17e-108: 366: 28.31
+	Hs
		900981 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		FMN2_HUMAN (561-1024): 7.13e-104: 361: 23.54
+	Hs
		925673 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		FMN2_HUMAN (561-1024): 7.13e-104: 361: 23.54
+	Hs
		237579 RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00		DIAP1_HUMAN (20-605): 6.9e-99: 342: 23.78
+	Hs
		237586 RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22		DIAP1_HUMAN (20-605): 6.9e-99: 342: 23.78
+	Hs
		237551 RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71		DIAP1_HUMAN (20-605): 6.9e-99: 342: 23.78