HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	27705803, 33022573, 24981860, 22325352
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 406
+	Mm
		903677 WDR5_MOUSE (1-334): 2.77e-131: 379: 100.00		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		903455 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		717626 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		903378 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		903462 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		903492 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		749312 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Mm
		1206589 TBL1R_MOUSE (66-333): 1.58e-60: 203: 24.91		RING2_MOUSE (8-406): 2.94e-100: 303: 54.25
+	Hs
		1304089 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		209398 PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		1281338 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		717884 SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		749840 TBL1R_HUMAN (82-333): 6.52e-60: 201: 26.28		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Dm
		1279331 EBI_DROME (6-202): 3.98e-57: 198: 27.75		Q9VV77_DROME (33-129): 1.77e-37: 137: 27.00
+	Hs
		585027 FBXW7_HUMAN (198-333): 4.06e-28: 116: 30.15		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		196962 PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		749764 SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63