HitPredict

Interactor 1: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Interactor 2: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	26186194, 28514442, 33961781, 27705803, 34316702, 22325352
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 228
+	Hs
		903357 WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1233115 POC1B_HUMAN (5-251): 5.05e-84: 263: 27.89		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00