HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31980649, 21706016, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 217
+	Hs
		909427 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924498 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Dm
		954994 1433E_DROME (1-243): 1.58e-140: 396: 63.37		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Hs
		683253 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411661 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Dm
		664604 1433Z_DROME (2-242): 1.36e-108: 314: 74.69		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Hs
		782766 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337416 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789053 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		782764 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337415 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789052 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337436 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789060 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		275184 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		411666 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		683181 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		337366 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		683185 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		337420 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46