Protein: DC1L2
Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)

Gene: DC1L2, DYNC1LI2
Organism: Homo sapiens
Interactions: 121
UniProt ID: O43237

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000776 - kinetochore
GO:0005524 - ATP binding
GO:0005770 - late endosome
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210568

DYHC1
Cytoplasmic dynein 1 heavy chain 1

6

2

High-throughput

0.945

High

210619

NINL
Ninein-like protein

3

3

High-throughput

0.827

High

210622

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

2

2

High-throughput

0.811

High

210559

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

6

8

Small-scale

0.734

High

210551

DYLT1
Dynein light chain Tctex-type 1

4

2

High-throughput

0.694

High

210585

RASEF
Ras and EF-hand domain-containing protein

1

2

High-throughput

0.691

High

210550

DYL1
Dynein light chain 1, cytoplasmic

3

3

High-throughput

0.675

High

156573

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

3

9

High-throughput

0.667

High

210620

C2CD2
C2 domain-containing protein 2

3

1

High-throughput

0.667

High

210567

DCTN1
Dynactin subunit 1

3

3

High-throughput

0.656

High

210596

DYL2
Dynein light chain 2, cytoplasmic

3

3

High-throughput

0.650

High

210510

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.618

High

210544

ACTZ
Alpha-centractin

2

4

High-throughput

0.611

High

210561

DCTN2
Dynactin subunit 2

2

1

High-throughput

0.611

High

210513

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

210586

NIN
Ninein

2

3

High-throughput

0.584

High

210542

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

210537

BRCA2
Breast cancer type 2 susceptibility protein

1

1

Small-scale

0.561

High

210514

GGYF1
GRB10-interacting GYF protein 1

1

3

High-throughput

0.536

High

210524

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

210530

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.536

High

210535

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.536

High

210536

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

210540

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

210552

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

210554

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

1

High-throughput

0.536

High

210563

CUL3
Cullin-3

1

2

High-throughput

0.536

High

210571

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

210601

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

210611

DLRB1
Dynein light chain roadblock-type 1

1

1

High-throughput

0.536

High

210558

DEMA
Dematin

1

0

High-throughput

0.518

High

210526

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

210543

PCBP4
Poly(rC)-binding protein 4

1

0

High-throughput

0.513

High

210583

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

185265

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

210594

GLMN
Glomulin

1

1

High-throughput

0.489

High

210518

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

210512

SYNJ1
Synaptojanin-1

1

2

High-throughput

0.479

High

210517

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

210519

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

210522

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

210533

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

210539

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

210541

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.479

High

210546

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

210547

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

210548

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.479

High

210549

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

210556

CALD1
Caldesmon

1

2

High-throughput

0.479

High

210560

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

210564

CUL4B
Cullin-4B

1

2

High-throughput

0.479

High

210566

SEPT6
Septin-6

1

2

High-throughput

0.479

High

210569

CASP8
Caspase-8

1

1

High-throughput

0.479

High

210570

ELOB
Elongin-B

1

1

High-throughput

0.479

High

210572

ITSN1
Intersectin-1

1

1

High-throughput

0.479

High

210581

HOOK3
Protein Hook homolog 3

1

3

High-throughput

0.479

High

210591

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.479

High

210592

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

210600

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

210602

SH3G1
Endophilin-A2

1

2

High-throughput

0.479

High

210603

COR1B
Coronin-1B

1

5

High-throughput

0.479

High

210604

SRBS1
Sorbin and SH3 domain-containing protein 1

1

2

High-throughput

0.479

High

210606

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.479

High

210612

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.479

High

210613

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

210614

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

1

High-throughput

0.479

High

210615

DBNL
Drebrin-like protein

1

3

High-throughput

0.479

High

210521

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.460

High

164186

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

178683

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.458

High

180179

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

208436

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

High-throughput

0.458

High

210523

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

210527

ICAL
Calpastatin

1

0

High-throughput

0.458

High

210555

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

210557

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.458

High

210565

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

210573

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

210575

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.458

High

210582

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.458

High

210588

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.458

High

210590

TRI58
E3 ubiquitin-protein ligase TRIM58

1

0

Small-scale

0.458

High

210598

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.458

High

210599

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

210605

CEP41
Centrosomal protein of 41 kDa

1

0

High-throughput

0.458

High

210610

JUPI2
Jupiter microtubule associated homolog 2

1

0

High-throughput

0.458

High

210616

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

210534

EAA1
Excitatory amino acid transporter 1

1

2

High-throughput

0.445

High

210576

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

104878

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

210515

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.437

High

210516

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

210520

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

210525

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

210532

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

210545

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

210577

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

210579

MAVS
Mitochondrial antiviral-signaling protein

1

4

High-throughput

0.437

High

210584

PHAR4
Phosphatase and actin regulator 4

1

2

High-throughput

0.437

High

210589

ARL10
ADP-ribosylation factor-like protein 10

1

2

High-throughput

0.437

High

210593

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

210609

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

210617

COR1C
Coronin-1C

1

3

High-throughput

0.437

High

210538

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.279

Low

210562

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

210608

CSTL1
Cystatin-like 1

1

0

High-throughput

0.279

Low

210511

TPD54
Tumor protein D54

1

0

High-throughput

0.249

Low

210528

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

210529

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.249

Low

210531

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

210574

ATG2A
Autophagy-related protein 2 homolog A

1

0

High-throughput

0.249

Low

210580

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

210587

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.249

Low

210595

EFHD2
EF-hand domain-containing protein D2

1

0

High-throughput

0.249

Low

210597

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.249

Low

210607

TANC1
Protein TANC1

1

0

High-throughput

0.249

Low

210618

PLAK2
PALM2-AKAP2 fusion protein

1

0

High-throughput

0.249

Low

210621

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.249

Low

210578

Q6ZUH1
cDNA FLJ43719 fis, clone TESOP2006060

1

0

High-throughput

0.238

Low

210553

TAGL
Transgelin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025